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- Article] Dopamine D-1 Receptors and Nonlinear Probability Weighting in Risky Choice
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DocNo of ILP: 2337
Doc. Type: Article
Title: Dopamine D-1 Receptors and Nonlinear Probability Weighting in Risky Choice
Authors: Takahashi, H; Matsui, H; Camerer, C; Takano, H; Kodaka, F; Ideno, T; Okubo, S; Takemura, K; Arakawa, R; Eguchi, Y; Murai, T; Okubo, Y; Kato, M; Ito, H; Suhara, T
Full Name of Authors: Takahashi, Hidehiko; Matsui, Hiroshi; Camerer, Colin; Takano, Harumasa; Kodaka, Fumitoshi; Ideno, Takashi; Okubo, Shigetaka; Takemura, Kazuhisa; Arakawa, Ryosuke; Eguchi, Yoko; Murai, Toshiya; Okubo, Yoshiro; Kato, Motoichiro; Ito, Hiroshi; Suhara, Tetsuya
Keywords by Author:
Keywords Plus: POSITRON-EMISSION-TOMOGRAPHY; DECISION-MAKING; HUMAN BRAIN; C-11 RACLOPRIDE; NOVELTY SEEKING; PROSPECT-THEORY; NEURAL BASIS; PET; BINDING; RELEASE
Abstract: Misestimating risk could lead to disadvantaged choices such as initiation of drug use (or gambling) and transition to regular drug use (or gambling). Although the normative theory in decision-making under risks assumes that people typically take the probability-weighted expectation over possible utilities, experimental studies of choices among risks suggest that outcome probabilities are transformed nonlinearly into subjective decision weights by a nonlinear weighting function that overweights low probabilities and underweights high probabilities. Recent studies have revealed the neurocognitive mechanism of decision-making under risk. However, the role of modulatory neurotransmission in this process remains unclear. Using positron emission tomography, we directly investigated whether dopamine D-1 and D-2 receptors in the brain are associated with transformation of probabilities into decision weights in healthy volunteers. The binding of striatal D-1 receptors is negatively correlated with the degree of nonlinearity of weighting function. Individuals with lower striatal D-1 receptor density showed more pronounced overestimation of low probabilities and underestimation of high probabilities. This finding should contribute to a better understanding of the molecular mechanism of risky choice, and extreme or impaired decision-making observed in drug and gambling addiction.
Cate of OECD: Basic medicine
Year of Publication: 2010
Business Area: gamble
Detail Business: gamble
Country: USA
Study Area:
Name of Journal: JOURNAL OF NEUROSCIENCE
Language: English
Country of Authors: [Takahashi, Hidehiko] Kyoto Univ, Grad Sch Med, Dept Psychiat, Sakyo Ku, Kyoto 6068507, Japan; [Takahashi, Hidehiko; Matsui, Hiroshi; Takano, Harumasa; Kodaka, Fumitoshi; Arakawa, Ryosuke; Eguchi, Yoko; Ito, Hiroshi; Suhara, Tetsuya] Natl Inst Radiol Sci, Dept Mol Neuroimaging, Mol Imaging Ctr, Chiba 2638555, Japan; [Takahashi, Hidehiko] Japan Sci & Technol Agcy, Precursory Res Embryon Sci & Technol PRESTO, Saitama 3320012, Japan; [Takahashi, Hidehiko] Tamagawa Univ, Brain Sci Inst, Tokyo 1948610, Japan; [Camerer, Colin] CALTECH, Div Humanities & Social Sci, Pasadena, CA 91125 USA; [Ideno, Takashi; Okubo, Shigetaka; Takemura, Kazuhisa] Waseda Univ, Dept Psychol, Tokyo 1628644, Japan; [Okubo, Yoshiro] Nippon Med Sch, Dept Neuropsychiat, Tokyo 1138603, Japan; [Kato, Motoichiro] Keio Univ, Sch Med, Dept Neuropsychiat, Tokyo 1608582, Japan
Press Adress: Takahashi, H (reprint author), Kyoto Univ, Grad Sch Med, Dept Psychiat, Sakyo Ku, 54 Shogoin Kawara Cho, Kyoto 6068507, Japan.
Email Address: hidehiko@kuhp.kyoto-u.ac.jp
Citaion:
Funding: Ministry of Education, Culture, Sports, Science and Technology (MEXT)
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Number of Citaion: 49
Publication: SOC NEUROSCIENCE
City of Publication: WASHINGTON
Address of Publication: 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
ISSN: 0270-6474
29-Character Source Abbreviation: J NEUROSCI
ISO Source Abbreviation: J. Neurosci.
Volume: 30
Version: 49
Start of File: 16567
End of File: 16572
DOI: 10.1523/JNEUROSCI.3933-10.2010
Number of Pages: 6
Web of Science Category: Neurosciences
Subject Category: Neurosciences & Neurology
Document Delivery Number: 691NW
Unique Article Identifier: WOS:000285089100018
[이 게시물은 HyeJung Mo…님에 의해 2015-05-20 14:44:04 GAMBLING에서 이동 됨]
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