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- Article; Proceedings Paper] Efficacy of omeprazole for the prevention of exercise-induced gastritis in racing Alaskan sled dogs
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DocNo of ILP: 6032
Doc. Type: Article; Proceedings Paper
Title: Efficacy of omeprazole for the prevention of exercise-induced gastritis in racing Alaskan sled dogs
Authors: Davis, MS; Willard, MD; Nelson, SL; McCullough, SM; Mandsager, RE; Roberts, J; Payton, ME
Full Name of Authors: Davis, MS; Willard, MD; Nelson, SL; McCullough, SM; Mandsager, RE; Roberts, J; Payton, ME
Keywords by Author: acid suppression; dog; gastric disease
Keywords Plus: GASTROINTESTINAL SYMPTOMS; THOROUGHBRED RACEHORSES; PHYSIOLOGY; CIMETIDINE; RUNNERS; LESIONS; THERAPY
Abstract: Exercise-induced gastritis and gastric ulcers are common in humans and horses, and recently have been described in racing sled dogs. The cause of exercise-induced gastric disease is not completely understood in any species, but pharmacologic suppression of acid secretion is an effective treatment in humans and horses. Thus, we tested the hypothesis that omeprazole, a proton-pump inhibitor shown to reduce gastric acid secretion in dogs, would reduce the severity of exercise-induced gastric disease. Three teams of 16 dogs each competing in the 2002 Iditarod Sled Dog Race were recruited for participation. Within each team, dogs were randomly assigned to either treatment (20 mg omeprazole PO q24h) or placebo. Treatments were administered until either completion of the race or withdrawal of an individual dog from competition. Gastric endoscopy was performed in all dogs 24 hours after completion or withdrawal, and the gastric mucosa was scored by using a subjective severity score (0 = normal, 3 = numerous bleeding ulcers). Treatment with omeprazole significantly reduced mean gastric severity score compared to placebo (omeprazole: 0.65 +/- 0.17, placebo: 1.09 +/- 0.18; P = .028), but also was associated with increased frequency of diarrhea during the race (omeprazole 54%, placebo 21%; P = .017). Examination of our data suggests that omeprazole may be an effective treatment for exercise-induced gastric disease in racing sled dogs. However, further investigation regarding the cause and clinical relevance of diarrhea associated with omeprazole treatment must be conducted before omeprazole can be recommended for routine prophylactic treatment in these athletes.
Cate of OECD: Veterinary science
Year of Publication: 2003
Business Area: horse race
Detail Business: racehorse
Country: USA
Study Area:
Name of Journal: JOURNAL OF VETERINARY INTERNAL MEDICINE
Language: English
Country of Authors: Oklahoma State Univ, Dept Physiol Sci, Stillwater, OK 74078 USA; Texas A&M Univ, Dept Small Anim Clin Sci, College Stn, TX 77843 USA; Iditarod Trail Comm, Wasilla, AK USA; Univ Illinois, Dept Vet Clin Med, Urbana, IL 61801 USA; Oklahoma State Univ, Dept Vet Clin Sci, Stillwater, OK 74078 USA; Oklahoma State Univ, Dept Stat, Stillwater, OK 74078 USA
Press Adress: Davis, MS (reprint author), Oklahoma State Univ, Dept Physiol Sci, 264 McElroy Hall, Stillwater, OK 74078 USA.
Email Address:
Citaion:
Funding:
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Number of Citaion: 35
Publication: AMER COLL VETERINARY INTERNAL MEDICINE
City of Publication: LAKEWOOD
Address of Publication: 7175 W JEFFERSON AVE, STE 2125, LAKEWOOD, CO 80235 USA
ISSN: 0891-6640
29-Character Source Abbreviation: J VET INTERN MED
ISO Source Abbreviation: J. Vet. Intern. Med.
Volume: 17
Version: 2
Start of File: 163
End of File: 166
DOI: 10.1892/0891-6640(2003)017<0163:EOOFTP>2.3.CO;2
Number of Pages: 4
Web of Science Category: Veterinary Sciences
Subject Category: Veterinary Sciences
Document Delivery Number: 656FK
Unique Article Identifier: WOS:000181598000009
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