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- Article] Autologous bone marrow mesenchymal stromal cells for regeneration of injured equine ligaments and tendons: A clinical report
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DocNo of ILP: 537
Doc. Type: Article
Title: Autologous bone marrow mesenchymal stromal cells for regeneration of injured equine ligaments and tendons: A clinical report
Authors: Renzi, S; Ricco, S; Dotti, S; Sesso, L; Grolli, S; Cornali, M; Carlin, S; Patruno, M; Cinotti, S; Ferrari, M
Full Name of Authors: Renzi, S.; Ricco, S.; Dotti, S.; Sesso, L.; Grolli, S.; Cornali, M.; Carlin, S.; Patruno, M.; Cinotti, S.; Ferrari, M.
Keywords by Author: Mesenchymal stromal cells; Horse; Orthopedic disease; Regenerative medicine; Pin firing
Keywords Plus: PLATELET-RICH PLASMA; STEM-CELLS; IN-VITRO; DIFFERENTIATION; TENDINOPATHY; HORSES
Abstract: The use of Mesenchymal Stromal Cells (MSCs) in orthopedic practice has recently and rapidly acquired an important role. Therapies based on the use of MSCs for the treatment of acute injuries as well as chronic inflammatory disorders are gradually becoming clinical routine. These cells have demonstrated intriguing therapeutic potentialities (i.e.: inflammation control, tissue regeneration and pathological scar prevention), that have been taken into-consideration for use in both human and veterinary medicine. In particular, horses represent high performance athletes considered models for human pathologies since musculo-skeletal disorders frequently occur in this species. In the past, repair of tendon injures were performed by different methods. In particular, clinical therapy was based on ice application, bandage, box rest and controlled exercise. An alternative approach consisted on the use of corticosteroid (inflammation reduction) and other drugs (sodium hyaluronate, polysulphated glycosaminoglycans, beta aminoproprionitrile fumarate). Furthermore, surgical treatments like accessory ligament desmotomy, local irritation by line firing or pin firing were commonly used. More recently ultrasound, laser therapy, electromagnetic field therapy have been considered. Unfortunately, they did not allow complete tissue healing and quite often animals did not regain competitiveness. In order to minimize this inconvenience, the use of MSCs has been introduced as an alternative to the traditional approach since it represents a potential tool to improve tissue regeneration. Aim of this study was to evaluate the capability of MSCs to improve the functional outcome of horses affected by tendonitis and desmitis. Thirty-three breed and activity-matched horses affected by tendonitis or desmitis, were included in clinical trial scored for lesions and subdivided into two groups. Group 1 animals were treated with autologous MSCs, associated with platelet rich plasma (group 1). Bone marrow samples were collected from the sternum of the treated horses and processed in order to isolate MSCs. Following cell therapy, they were subjected to a rehabilitation period and their ability to resume training was evaluated. In this study, implanted MSCs caused no adverse reactions and thirteen out of the eighteen inoculated horses returned to race competitions. On the contrary, no improvement was seen in the twelve animals of group 2 treated with pin firing, that were not able to resume sport activity. In conclusion the clinical trial proves the safety of equine bone-marrow derived MSCs and a successful outcome of the treated animals that returned to their previous level of sport activity. (C) 2013 Elsevier Ltd. All rights reserved.
Cate of OECD: Veterinary science
Year of Publication: 2013
Business Area: other
Detail Business: medicine & science
Country: England
Study Area: Reporting, clinical trial, clinical trial, drug, disease
Name of Journal: RESEARCH IN VETERINARY SCIENCE
Language: English
Country of Authors: [Renzi, S.; Dotti, S.; Cinotti, S.; Ferrari, M.] Ist Zooprofilatt Sperimentale Lombardia & Emilia, I-25124 Brescia, Italy; [Ricco, S.] Univ Parma, Dept Anim Hlth, I-43126 Parma, Italy; [Sesso, L.] Univ Parma, Dept Anim Hlth, I-21017 Samarate, VA, Italy; [Grolli, S.] Univ Parma, Dept Anim Prod Vet Biotechnol Food Qual & Safety, I-43126 Parma, Italy; [Cornali, M.; Carlin, S.] Racecourse Vet Surg Clin, I-39012 Merano, BZ, Italy; [Patruno, M.] Univ Padua, Dept Expt Vet Sci, I-35020 Legnaro, PD, Italy
Press Adress: Renzi, S (reprint author), IZSLER, Cell Culture Ctr, Via Bianchi 9, I-25124 Brescia, Italy.
Email Address: sabrina.renzi@izsler.it
Citaion:
Funding: IZSLER, Brescia, Italy (IZSLER project)
Lists of Citation: Abramson J. H., 2004, EPIDEMIOLOGIC PERSPE, P1; Bifari Francesco, 2010, World J Stem Cells, V2, P50, DOI 10.4252/wjsc.v2.i3.50; Bosch G, 2011, SCAND J MED SCI SPOR, V21, P554, DOI 10.1111/j.1600-0838.2009.01070.x; Boswell SG, 2012, ARTHROSCOPY, V28, P429, DOI 10.1016/j.arthro.2011.10.018; Bourzac C, 2010, EQUINE VET J, V42, P519, DOI 10.1111/j.2042-3306.2010.00098.x; Davis C.S., 2005, EQUINE SURG, P1086; Del Bue M, 2008, VET RES COMMUN, V32, pS51, DOI 10.1007/s11259-008-9093-3; Denoix JM, 2008, B ACAD NAT MED PARIS, V192, P521; Fortier LA, 1998, AM J VET RES, V59, P1182; Godwin EE, 2012, EQUINE VET J, V44, P25, DOI 10.1111/j.2042-3306.2011.00363.x; Hayward M., 2001, FIRING HORSES REV AN, P1; Larsen S, 2011, PATHOLOGY, V43, P592, DOI 10.1097/PAT.0b013e32834ab72d; Maia L, 2009, J EQUINE VET SCI, V29, P618, DOI 10.1016/j.jevs.2009.07.001; Nixon AJ, 2008, AM J VET RES, V69, P928, DOI 10.2460/ajvr.69.7.928; Pittenger MF, 1999, SCIENCE, V284, P143, DOI 10.1126/science.284.5411.143; Reef VB, 1998, EQUINE DIAGNOSTIC UL, P39; Schwarz C, 2011, VET RES COMMUN, V35, P487, DOI 10.1007/s11259-011-9492-8; Smith RKW, 2008, DISABIL REHABIL, V30, P1752, DOI 10.1080/09638280701788241; Taylor SE, 2011, VET CLIN N AM-EQUINE, V27, P263, DOI 10.1016/j.cveq.2011.05.003; Torricelli P, 2011, INT ORTHOP, V35, P1569, DOI 10.1007/s00264-011-1237-3; Violini S, 2009, BMC CELL BIOL, V10, DOI 10.1186/1471-2121-10-29
Number of Citaion: 21
Publication: ELSEVIER SCI LTD
City of Publication: OXFORD
Address of Publication: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
ISSN: 0034-5288
29-Character Source Abbreviation: RES VET SCI
ISO Source Abbreviation: Res. Vet. Sci.
Volume: 95
Version: 1
Start of File: 272
End of File: 277
DOI: 10.1016/j.rvsc.2013.01.017
Number of Pages: 6
Web of Science Category: Veterinary Sciences
Subject Category: Veterinary Sciences
Document Delivery Number: 162TT
Unique Article Identifier: WOS:000320289600044
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