경마 | Cases & Studies in Horse Racing | 赛马
- date : 2015-05-20 01:10|hit : 2750
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- Article] Peeling Back the Evolutionary Layers of Molecular Mechanisms Responsive to Exercise-Stress in the Skeletal Muscle of the Racing Horse
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DocNo of ILP: 613
Doc. Type: Article
Title: Peeling Back the Evolutionary Layers of Molecular Mechanisms Responsive to Exercise-Stress in the Skeletal Muscle of the Racing Horse
Authors: Kim, H; Lee, T; Park, W; Lee, JW; Kim, J; Lee, BY; Ahn, H; Moon, S; Cho, S; Do, KT; Kim, HS; Lee, HK; Lee, CK; Kong, HS; Yang, YM; Park, J; Kim, HM; Kim, BC; Hwang, S; Bhak, J; Burt, D; Park, KD; Cho, BW; Kim, H
Full Name of Authors: Kim, Hyeongmin; Lee, Taeheon; Park, WonCheoul; Lee, Jin Woo; Kim, Jaemin; Lee, Bo-Young; Ahn, Hyeonju; Moon, Sunjin; Cho, Seoae; Do, Kyoung-Tag; Kim, Heui-Soo; Lee, Hak-Kyo; Lee, Chang-Kyu; Kong, Hong-Sik; Yang, Young-Mok; Park, Jongsun; Kim, Hak-Min; Kim, Byung Chul; Hwang, Seungwoo; Bhak, Jong; Burt, Dave; Park, Kyoung-Do; Cho, Byung-Wook; Kim, Heebal
Keywords by Author: horse; exercise; evolution; RNA sequencing; re-sequencing
Keywords Plus: DNA-SEQUENCING DATA; RNA-SEQ; PHYLOGENETIC ANALYSIS; THOROUGHBRED HORSES; POPULATION-GENETICS; POSITIVE SELECTION; ENDOCRINE ORGAN; R PACKAGE; GENOME; PROTEIN
Abstract: The modern horse (Equus caballus) is the product of over 50 million yrs of evolution. The athletic abilities of the horse have been enhanced during the past 6000 yrs under domestication. Therefore, the horse serves as a valuable model to understand the physiology and molecular mechanisms of adaptive responses to exercise. The structure and function of skeletal muscle show remarkable plasticity to the physical and metabolic challenges following exercise. Here, we reveal an evolutionary layer of responsiveness to exercise-stress in the skeletal muscle of the racing horse. We analysed differentially expressed genes and their co-expression networks in a large-scale RNA-sequence dataset comparing expression before and after exercise. By estimating genome-wide d(N)/d(S) ratios using six mammalian genomes, and F-ST and iHS using re-sequencing data derived from 20 horses, we were able to peel back the evolutionary layers of adaptations to exercise-stress in the horse. We found that the oldest and thickest layer (d(N)/d(S)) consists of system-wide tissue and organ adaptations. We further find that, during the period of horse domestication, the older layer (F-ST) is mainly responsible for adaptations to inflammation and energy metabolism, and the most recent layer (iHS) for neurological system process, cell adhesion, and proteolysis.
Cate of OECD: Biological sciences
Year of Publication: 2013
Business Area: horse race
Detail Business: racehorse
Country: England
Study Area: industry, production, network & communication, network, older, choice
Name of Journal: DNA RESEARCH
Language: English
Country of Authors: [Kim, Hyeongmin; Lee, Taeheon; Park, WonCheoul; Lee, Bo-Young; Ahn, Hyeonju; Moon, Sunjin; Lee, Chang-Kyu; Kim, Heebal] Seoul Natl Univ, Dept Agr Biotechnol, Seoul 151921, South Korea; [Kim, Hyeongmin; Lee, Taeheon; Park, WonCheoul; Lee, Bo-Young; Ahn, Hyeonju; Moon, Sunjin; Lee, Chang-Kyu; Kim, Heebal] Seoul Natl Univ, Res Inst Agr & Life Sci, Seoul 151921, South Korea; [Lee, Jin Woo] Korea Racing Author, Horse Ind Res Ctr, Gwacheon 471711, South Korea; [Kim, Jaemin; Kim, Heebal] Seoul Natl Univ, Interdisciplinary Program Bioinformat, Seoul 151742, South Korea; [Cho, Seoae; Kim, Heebal] Seoul Natl Univ, C&K Genom, Seoul 151919, South Korea; [Do, Kyoung-Tag; Cho, Byung-Wook] Pusan Natl Univ, Coll Life Sci, Dept Anim Sci, Miryang 627702, South Korea; [Kim, Heui-Soo] Pusan Natl Univ, Coll Nat Sci, Dept Biol Sci, Pusan 609735, South Korea; [Lee, Hak-Kyo; Kong, Hong-Sik; Park, Kyoung-Do] Hankyong Natl Univ, Genom Informat Ctr, Anseong 456749, South Korea; [Yang, Young-Mok] Konkuk Univ, Sch Med, Dept Pathol, Seoul 143701, South Korea; [Yang, Young-Mok] Konkuk Univ, Inst Biomed Sci & Technol, Seoul 143701, South Korea; [Park, Jongsun; Kim, Hak-Min; Kim, Byung Chul] Personal Genom Inst, Genom Dept, Suwon 443270, South Korea; [Hwang, Seungwoo] KRIBB, KOBIC, Taejon 305806, South Korea; [Bhak, Jong] TheragenEtex, TBI, Suwon 443270, South Korea; [Burt, Dave] Univ Edinburgh, Roslin Inst, Edinburgh EH25 9GR, Midlothian, Scotland
Press Adress: Park, KD (reprint author), Hankyong Natl Univ, Genom Informat Ctr, Anseong 456749, South Korea.
Email Address: doobalo@hknu.ac.kr; bwcho@pusan.ac.kr; heebal@snu.ac.kr
Citaion:
Funding: Next-Generation BioGreen 21 Program [11008106, PJ008191]; Rural Development Administration, Republic of Korea; Korea Racing Authority (KRA) [0569-20110008]
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Number of Citaion: 61
Publication: OXFORD UNIV PRESS
City of Publication: OXFORD
Address of Publication: GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
ISSN: 1340-2838
29-Character Source Abbreviation: DNA RES
ISO Source Abbreviation: DNA Res.
Volume: 20
Version: 3
Start of File: 287
End of File: 298
DOI: 10.1093/dnares/dst010
Number of Pages: 12
Web of Science Category: Genetics & Heredity
Subject Category: Genetics & Heredity
Document Delivery Number: 177VT
Unique Article Identifier: WOS:000321404200008
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