경마 | Cases & Studies in Horse Racing | 赛马
- date : 2015-05-20 01:10|hit : 2352
-
- Article] The Effect of Exercise and Nutritional Supplementation on Proinflammatory Cytokine Expression in Young Racehorses During Training
-
DocNo of ILP: 991
Doc. Type: Article
Title: The Effect of Exercise and Nutritional Supplementation on Proinflammatory Cytokine expression in Young Racehorses During Training
Authors: Horohov, DW; Sinatra, ST; Chopra, RK; Jankowitz, S; Betancourt, A; Bloomer, RJ
Full Name of Authors: Horohov, David W.; Sinatra, Stephen T.; Chopra, Raj K.; Jankowitz, Stanley; Betancourt, Alejandra; Bloomer, Richard J.
Keywords by Author: Exercise; Inflammation; Adaptation; Malondialdehyde; Lactate; Supplementation
Keywords Plus: NONSTEROIDAL ANTIINFLAMMATORY DRUGS; MESSENGER-RNA exPRESSION; BLOOD MONONUCLEAR-CELLS; EQUINE INFLUENZA-VIRUS; TUMOR-NECROSIS-FACTOR; ANTIOXIDANT SUPPLEMENTATION; LIPID-PEROXIDATION; IMMUNE-SYSTEM; MUSCLE DAMAGE; L-CARNITINE
Abstract: The inflammatory response to vigorous exercise ranges from the mild symptoms of delayed-onset muscle soreness to debilitating injuries affecting soft tissue, joint, and bone. Although there is a great deal of information available on the inflammatory response to exercise in human athletes, less information is available regarding the inflammatory response to exercise in young horses undergoing training for racing careers. Here, we assessed the cytokine response to exercise in a group of young Thoroughbred racehorses during their initial training. Because there is interest in non-pharmacologic approaches to control or ameliorate exercise-induced inflammation, we also examined the anti-inflammatory effect of a nutritional supplement fed to half of the horses undergoing training. Twenty-five Thoroughbred horses aged 2 years were followed through their initial race training. Peripheral blood samples were collected at various times during the exercise for the quantitation of lactic acid, oxidative stress, and inflammatory cytokine gene expression. There was an intensity-dependent effect of exercise on lactate, malondialdehyde, and proinflammatory cytokine gene expression. Although training itself was associated with an overall reduction in inflammatory markers, horses receiving the supplement exhibited further reductions in their indicators of inflammation. As such, this study provides novel evidence of nutritional supplementation reducing postexercise inflammation. (C) 2012 Elsevier Inc. All rights reserved.
Cate of OECD: Veterinary science
Year of Publication: 2012
Business Area: horse race
Detail Business: racehorse
Country: USA
Study Area:
Name of Journal: JOURNAL OF EQUINE VETERINARY SCIENCE
Language: English
Country of Authors: [Horohov, David W.; Betancourt, Alejandra] Univ Kentucky, Dept Vet Sci, Maxwell Gluck Equine Res Ctr, Lexington, KY 40546 USA; [Sinatra, Stephen T.] Univ Connecticut, Sch Med, Dept Med, Farmington, CT USA; [Chopra, Raj K.; Jankowitz, Stanley] GelTec Tishcon Corp, Westbury, NY USA; [Bloomer, Richard J.] Univ Memphis, Cardioresp Metab Lab, Memphis, TN 38152 USA
Press Adress: Horohov, DW (reprint author), Univ Kentucky, Dept Vet Sci, Maxwell Gluck Equine Res Ctr 128H, Lexington, KY 40546 USA.
Email Address: DWHoro2@uky.edu
Citaion:
Funding: W.R. Mills Endowment
Lists of Citation: Abd El-Gawad HM, 2001, PHARMACOL RES, V43, P257, DOI 10.1006/phrs.2000.0781; Aggarwal BB, 2009, INT J BIOCHEM CELL B, V41, P40, DOI 10.1016/j.biocel.2008.06.010; Aguilo A, 2004, INT J SPORT NUTR EXE, V14, P147; Ainsworth DM, 2003, VET IMMUNOL IMMUNOP, V91, P61, DOI 10.1016/S0165-2427(02)00274-X; Anand P, 2008, BIOCHEM PHARMACOL, V76, P1590, DOI 10.1016/j.bcp.2008.08.008; Pyne D B, 1994, Aust J Sci Med Sport, V26, P49; Auer D. E., 1989, Veterinary Clinical Pathology, V18, P21; Auvinet B, 1996, PFERDEHEILKUNDE, V12, P455; Bengmark S, 2009, NUTR HOSP, V24, P273; Jacobs PL, 2009, J INT SOC SPORT NUTR, V6, DOI 10.1186/1550-2783-6-9; BLANK SE, 1994, J APPL PHYSIOL, V76, P2031; Bloomer RJ, 2009, INT J VITAM NUTR RES, V79, P131, DOI 10.1024/0300-9831.79.3.131; Bonavolonta V, 2009, EUR J APPL PHYSL, V107, P105; Brancaccio P, 2010, CLIN CHEM LAB MED, V48, P757, DOI 10.1515/CCLM.2010.179; Camacho-Barquero L, 2007, INT IMMUNOPHARMACOL, V7, P333, DOI 10.1016/j.intimp.2006.11.006; Capomaccio Stefano, 2011, BMC Physiology, V11, P3, DOI 10.1186/1472-6793-11-3; Cave MC, 2008, NUTR CLIN PRACT, V23, P16, DOI 10.1177/011542650802300116; Chiaradia E, 1998, COMP BIOCHEM PHYS B, V119, P833, DOI 10.1016/S0305-0491(98)10001-9; Clarke JO, 2008, NUTR CLIN PRACT, V23, P49, DOI 10.1177/011542650802300149; Clutterbuck AL, 2009, ANN NY ACAD SCI, V1171, P428, DOI 10.1111/j.1749-6632.2009.04687.x; Colahan PT, 2002, EQUINE VET J S, V34, P154; Cooke M, 2008, J INT SOC SPORT NUTR, V5, DOI 10.1186/1550-2783-5-8; Courouce A, 1999, EQUINE VET J S, V31, P528; Cuzzocrea S, 2001, EUR J PHARMACOL, V426, P1, DOI 10.1016/S0014-2999(01)01175-X; de Moffarts B, 2006, EQUINE VET J S, V38, P254; Deaton CM, 2004, CLIN TECH EQUINE PRA, V2, P278, DOI DOI 10.1053/51534-7516(03)00070-2; De Moffarts B, 2007, VET J, V174, P113, DOI 10.1016/j.tvjl.2006.06.001; Dennis RA, 2004, J PHYSIOL-LONDON, V560, P617, DOI 10.1113/j.physiol.2004.067875; Dirikolu L, 2009, J VET PHARMACOL THER, V32, P271, DOI 10.1111/j.1365-2885.2008.01038.x; Donovan DC, 2007, VET IMMUNOL IMMUNOP, V118, P263, DOI 10.1016/j.vetimm.2007.05.015; Ducharme NG, 2009, AM J VET RES, V70, P758, DOI 10.2460/ajvr.70.6.758; Dyson PK, 2008, EQUINE VET J, V40, P650, DOI 10.2746/042516408X363242; Folsom RW, 2001, EQUINE VET J, V33, P664, DOI 10.2746/042516401776249417; Forsyth RK, 2006, EQUINE VET J S, V38, P622; Fortin G, 2011, VITAM HORM, V86, P353, DOI 10.1016/B978-0-12-386960-9.00015-0; FOSTER CVL, 1992, EQUINE VET J, V24, P52; Franck T, 2008, PHYSIOL RES, V57, P577; Goldhammer E, 2005, INT J CARDIOL, V100, P93, DOI 10.1016/j.ijcard.2004.08.073; Goodrich LR, 2006, VET J, V171, P51, DOI 10.1016/j.tvjl.2004.07.008; HAAHR PM, 1991, INT J SPORTS MED, V12, P223, DOI 10.1055/s-2007-1024672; Handschin C, 2008, NATURE, V454, P463, DOI 10.1038/nature07206; Hargreaves BJ, 2002, EQUINE VET J S, V34, P116; Heinecke LF, 2010, OSTEOARTHR CARTILAGE, V18, P220, DOI 10.1016/j.joca.2009.08.015; HOFFMANGOETZ L, 1994, J SPORT MED PHYS FIT, V34, P83; Horohov DW, 2003, EQUINE VET J, V35, P113, DOI 10.2746/042516403776114270; Horohov DW, 1999, AM J VET RES, V60, P643; Horohov DW, 1996, VET IMMUNOL IMMUNOP, V53, P221, DOI 10.1016/S0165-2427(96)05610-3; Izquierdo M, 2009, EUR J APPL PHYSIOL, V107, P397, DOI 10.1007/s00421-009-1139-x; Jentzsch AM, 1996, FREE RADICAL BIO MED, V20, P251, DOI 10.1016/0891-5849(95)02043-8; Jones JH, 2006, EQUINE VET J S, V38, P365; Kallings P, 1999, EQUINE VET J S, V30, P270; KALLINGS P, 1993, VET CLIN N AM-EQUINE, V9, P523; Kavazis AN, 2002, EQUINE VET J S, V34, P191; Kirschvink N, 2008, VET J, V177, P178, DOI 10.1016/j.tvjl.2007.07.033; Kolodziejczyk Joanna, 2011, Nutrition, V27, P693, DOI 10.1016/j.nut.2010.06.009; Lamprecht ED, 2009, J EQUINE VET SCI, V29, P298, DOI 10.1016/j.jevs.2009.04.004; Lamprecht ED, 2009, COMP EXERCISE PHYSL, V5, P115; Lee EG, 1999, J SPORT MED PHYS FIT, V39, P275; Ley C, 2009, RES VET SCI, V86, P490, DOI 10.1016/j.rvsc.2008.10.008; Ley C, 2007, J VET MED A, V54, P346, DOI 10.1111/j.1439-0442.2007.00956.x; Liburt NR, 2010, EQUINE VET J, V42, P280, DOI 10.1111/j.2042-3306.2010.00275.x; Liu C, 2011, VET IMMUNOL IMMUNOP, V143, P108, DOI 10.1016/j.vetimm.2011.06.031; Lunn DP, 2001, J AM VET MED ASSOC, V218, P900, DOI 10.2460/javma.2001.218.900; MACINTYRE DL, 1995, SPORTS MED, V20, P24, DOI 10.2165/00007256-199520010-00003; Margaritis I, 2008, NUTR RES REV, V21, P3, DOI 10.1017/S0954422408018076; Margaritis I, 2003, J AM COLL NUTR, V22, P147; MATSUKI N, 1991, J VET MED SCI, V53, P1001; MCMENIMAN NP, 1992, EQUINE VET J, V24, P482; MILLS PC, 1994, BRIT VET J, V150, P53; Moreira A, 2007, EUR J CLIN NUTR, V61, P443, DOI 10.1038/sj.ejcn.1602549; Morton AJ, 2005, RES VET SCI, V78, P189, DOI 10.1016/j.rvsc.2004.07.006; Moussaieff A, 2007, MOL PHARMACOL, V72, P1657, DOI 10.1124/mol.107.038810; Moussaieff A, 2009, J PHARM PHARMACOL, V61, P1281, DOI 10.1211/jpp/61.10.0003; Nielsen AR, 2007, APPL PHYSIOL NUTR ME, V32, P833, DOI 10.1139/H07-054; Nieman DC, 2006, J INTERF CYTOK RES, V26, P668, DOI 10.1089/jir.2006.26.668; Nieman DC, 2001, CAN J APPL PHYSIOL, V26, pS45; Nieman DC, 2005, BRAIN BEHAV IMMUN, V19, P398, DOI 10.1016/j.bbi.2005.03.008; Oke S, 2006, EQUINE VET J, V38, P93, DOI 10.2746/042516406775374306; Paulsen G, 2010, Scand J Med Sci Sports, V20, pe195, DOI 10.1111/j.1600-0838.2009.00947.x; Peake JM, 2007, J NUTR BIOCHEM, V18, P357, DOI 10.1016/j.jnutbio.2006.10.005; Pearson W, 2009, AM J VET RES, V70, P848, DOI 10.2460/ajvr.70.7.848; Pedersen BK, 1998, CAN J PHYSIOL PHARM, V76, P505, DOI 10.1139/cjpp-76-5-505; Pedersen BK, 2000, PHYSIOL REV, V80, P1055; Pedersen BK, 1997, INT J SPORTS MED, V18, pS2, DOI 10.1055/s-2007-972695; PEDERSEN BK, 1994, MED SCI SPORT EXER, V26, P140, DOI 10.1249/00005768-199402000-00003; Pedersen BK, 2006, ESSAYS BIOCHEM, V42, P105; Petersen EW, 2001, AM J PHYSIOL-CELL PH, V280, pC1570; Portier K, 2006, EQUINE VET J S, P279; Reed SK, 2006, AM J VET RES, V67, P398, DOI 10.2460/ajvr.67.3.398; RIVERO JL, 2002, EQUINE VET J S, V34, P269; Rosa FT, 2012, INT J FOOD SCI NUTR; ROSSDALE PD, 1985, VET REC, V116, P66; Saulez MN, 2010, AM J VET RES, V71, P447, DOI 10.2460/ajvr.71.4.447; Schmelzer C, 2008, BIOFACTORS, V32, P179; SEEHERMAN HJ, 1990, VET CLIN N AM-EQUINE, V6, P239; SHEPHARD RJ, 1994, SPORTS MED, V18, P340, DOI 10.2165/00007256-199418050-00006; Shinkai S, 1997, EXERC IMMUNOL REV, V3, P68; Sinatra ST, J EQUINE VE IN PRESS; Sinatra ST, 2009, ALTERN THER HEALTH M, V15, P48; Smith LL, 2000, MED SCI SPORT EXER, V32, P317, DOI 10.1097/00005768-200002000-00011; Smith LL, 2004, J STRENGTH COND RES, V18, P185; Suzuki K, 2002, EXERC IMMUNOL REV, V8, P6; Tanner RK, 2010, EUR J APPL PHYSIOL, V109, P551, DOI 10.1007/s00421-010-1379-9; TAYLOR MR, 1995, J CHROMATOGR A, V697, P389, DOI 10.1016/0021-9673(94)00834-V; Thomasy SM, 2004, J VET INTERN MED, V18, P550, DOI 10.1892/0891-6640(2004)18<550:TFCWNA>2.0.CO;2; Urso ML, 2003, TOXICOLOGY, V189, P41, DOI 10.1016/S0300-483X(03)00151-3; WAGNER DR, 1991, ANN NUTR METAB, V35, P297, DOI 10.1159/000177660; Walsh NP, 2011, EXERC IMMUNOL REV, V17, P6; Walson T, 2005, MED SCI SPORTS EXERC, V37, P63; Williams C. A., 2006, EQUINE VET J S, V36, P617; Williams CA, 2008, VET J, V178, P21, DOI 10.1016/j.tvjl.2007.06.004; Wilsher S, 2006, EQUINE VET J, V38, P113, DOI 10.2746/042516406776563305; Woods JA, 2009, IMMUNOL ALLERGY CLIN, V29, P381, DOI 10.1016/j.iac.2009.02.011; Zeyner A, 1999, ARCH ANIM NUTR, V52, P115
Number of Citaion: 114
Publication: ELSEVIER SCIENCE INC
City of Publication: NEW YORK
Address of Publication: 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
ISSN: 0737-0806
29-Character Source Abbreviation: J EQUINE VET SCI
ISO Source Abbreviation: J. Equine Vet. Sci.
Volume: 32
Version: 12
Start of File: 805
End of File: 815
DOI: 10.1016/j.jevs.2012.03.017
Number of Pages: 11
Web of Science Category: Veterinary Sciences
Subject Category: Veterinary Sciences
Document Delivery Number: 054RY
Unique Article Identifier: WOS:000312362100007
[이 게시물은 HyeJung Mo…님에 의해 2015-05-20 14:41:34 GAMBLING에서 이동 됨]
- reply : 0
-
- list
-
- prev
- next