학제간연구 | Interdisciplinary Studies in Gambling | 跨学科研究
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- Article] Single nucleotide polymorphisms of myostatin gene in Chinese domestic horses
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DocNo of ILP: 85
Doc. Type: Article
Title: Single nucleotide polymorphisms of myostatin gene in Chinese domestic horses
Authors: Li, R; Liu, DH; Cao, CN; Wang, SQ; Dang, RH; Lan, XY; Chen, H; Zhang, T; Liu, WJ; Lei, CZ
Full Name of Authors: Li, Ran; Liu, Dong-Hua; Cao, Chun-Na; Wang, Shao-Qiang; Dang, Rui-Hua; Lan, Xian-Yong; Chen, Hong; Zhang, Tao; Liu, Wu-Jun; Lei, Chu-Zhao
Keywords by Author: Chinese horse; MSTN; SNP; Genetic diversity
Keywords Plus: OPTIMUM RACING DISTANCE; MSTN GENE; IDENTIFICATION; ASSOCIATION; REGION; MUTATIONS; SOFTWARE; MUSCLE; CATTLE; BONE
Abstract: The myostatin gene (MSTN) is a genetic determinant of skeletal muscle growth. Single nucleotide polymorphisms (SNP) in MSTN are of importance due to their strong associations with horse racing performances. In this study, we screened the SNPs in MSTN gene in 514 horses from 15 Chinese horse breeds. Six SNPs (g.26 T>C, g.156 T>C, g.587A>G, g.598C>T, g.1485C>T, g.2115A>G) in MSTN gene were detected by sequencing and genotyped using PCR-RFLP method. The g.587A>G and g.598C>T residing in the 5'UTR region were novel SNPs identified by this study. The g2115A>G which have previously been associated with racing performances were present in Chinese horse breeds, providing valuable genetic information for evaluating the potential racing performances in Chinese domestic breeds. The six SNPs together defined thirteen haplotypes, demonstrating abundant haplotype diversities in Chinese horses. Most of the haplotypes were shared among different breeds with no haplotype restricted to a specific region or a single,horse breed. AMOVA analysis indicated that most of the genetic variance was attributable to differences among individuals without any significant contribution by the four geographical groups. This study will provide fundamental and instrumental genetic information for evaluating the potential racing performances of Chinese horse breeds. (C) 2013 Elsevier B.V. All rights reserved.
Cate of OECD: Biological sciences
Year of Publication: 2014
Business Area: horse race
Detail Business: horse race
Country: Netherlands
Study Area:
Name of Journal: GENE
Language: English
Country of Authors: [Li, Ran; Wang, Shao-Qiang; Dang, Rui-Hua; Lan, Xian-Yong; Chen, Hong; Lei, Chu-Zhao] Northwest A&F Univ, Coll Anim Sci & Technol, Shaanxi Key Lab Mol Biol Agr, Yangling 712100, Shaanxi, Peoples R China; [Liu, Dong-Hua] Hexi Univ, Inst Hexi Ecol & Oasis Agr, Zhangye 734000, Gansu, Peoples R China; [Cao, Chun-Na] Anim Husb & Vet Bur Yining, Yili 835100, Xinjiang, Peoples R China; [Zhang, Tao] Shaanxi Univ Technol, Hanzhong 723001, Shaanxi, Peoples R China; [Liu, Wu-Jun] Xinjiang Agr Univ, Urumqi 830052, Xinjiang, Peoples R China
Press Adress: Lei, CZ (reprint author), Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China.
Email Address: leichuzhao1118@126.com
Citaion:
Funding: National Natural Science Foundation of China [31072001]; National Science and Technology Support Program [2012BAD44B01]
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Number of Citaion: 27
Publication: ELSEVIER SCIENCE BV
City of Publication: AMSTERDAM
Address of Publication: PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
ISSN: 0378-1119
29-Character Source Abbreviation: GENE
ISO Source Abbreviation: Gene
Volume: 538
Version: 1
Start of File: 150
End of File: 154
DOI: 10.1016/j.gene.2013.12.027
Number of Pages: 5
Web of Science Category: Genetics & Heredity
Subject Category: Genetics & Heredity
Document Delivery Number: AC8WK
Unique Article Identifier: WOS:000332815600021
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