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- Article] Protein Catabolism and High Lipid Metabolism Associated with Long-Distance Exercise Are Revealed by Plasma NMR Metabolomics in Endurance Horses
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DocNo of ILP: 82
Doc. Type: Article
Title: Protein Catabolism and High Lipid Metabolism Associated with Long-Distance Exercise Are Revealed by Plasma NMR Metabolomics in Endurance Horses
Authors: Le Moyec, L; Robert, C; Triba, MN; Billat, VL; Mata, X; Schibler, L; Barrey, E
Full Name of Authors: Le Moyec, Laurence; Robert, Celine; Triba, Mohamed N.; Billat, Veronique L.; Mata, Xavier; Schibler, Laurent; Barrey, Eric
Keywords by Author:
Keywords Plus: BLOOD-SERUM; MODEL; RIDES
Abstract: During long distance endurance races, horses undergo high physiological and metabolic stresses. The adaptation processes involve the modulation of the energetic pathways in order to meet the energy demand. The aims were to evaluate the effects of long endurance exercise on the plasma metabolomic profiles and to investigate the relationships with the individual horse performances. The metabolomic profiles of the horses were analyzed using the non-dedicated methodology, NMR spectroscopy and statistical multivariate analysis. The advantage of this method is to investigate several metabolomic pathways at the same time in a single sample. The plasmas were obtained before exercise (BE) and post exercise (PE) from 69 horses competing in three endurance races at national level (130-160 km). Biochemical assays were also performed on the samples taken at PE. The proton NMR spectra were compared using the supervised orthogonal projection on latent structure method according to several factors. Among these factors, the race location was not significant whereas the effect of the race exercise (sample BE vs PE of same horse) was highly discriminating. This result was confirmed by the projection of unpaired samples (only BE or PE sample of different horses). The metabolomic profiles proved that protein, energetic and lipid metabolisms as well as glycoproteins content are highly affected by the long endurance exercise. The BE samples from finisher horses could be discriminated according to the racing speed based on their metabolomic lipid content. The PE samples could be discriminated according to the horse ranking position at the end of the race with lactate as unique correlated metabolite. As a conclusion, the metabolomic profiles of plasmas taken before and after the race provided a better understanding of the high energy demand and protein catabolism pathway that could expose the horses to metabolic disorders.
Cate of OECD: Other natural sciences
Year of Publication: 2014
Business Area: other
Detail Business: medicine & science
Country: USA
Study Area:
Name of Journal: PLOS ONE
Language: English
Country of Authors: [Le Moyec, Laurence; Billat, Veronique L.; Barrey, Eric] Univ Evry Val Essonne, INSERM, Unite Biol Integrat & Adaptat Exercice, Evry, France; [Robert, Celine; Mata, Xavier; Schibler, Laurent; Barrey, Eric] INRA, Jouy En Josas, France; [Triba, Mohamed N.] Univ Paris 13, Sorbonne Paris Cite, CNRS, Bobigny, France; [Robert, Celine] Univ Paris Est, Ecole Natl Vet Alfort, Maisons Alfort, France
Press Adress: Le Moyec, L (reprint author), Univ Evry Val Essonne, INSERM, Unite Biol Integrat & Adaptat Exercice, Evry, France.
Email Address: laurence.lemoyec@univ-evry.fr
Citaion:
Funding: French Institute of Horse and Equitation (IFCE); Eperon funds; Arabian Horse Association (ACA); Institut National de recherche en Agronomie (INRA); Ecole Nationale Veterinaire d'Alfort (ENVA); Region Ile de France (SESAME project)
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Number of Citaion: 23
Publication: PUBLIC LIBRARY SCIENCE
City of Publication: SAN FRANCISCO
Address of Publication: 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
ISSN: 1932-6203
29-Character Source Abbreviation: PLOS ONE
ISO Source Abbreviation: PLoS One
Volume: 9
Version: 3
Start of File:
End of File:
DOI: 10.1371/journal.pone.0090730
Number of Pages: 10
Web of Science Category: Multidisciplinary Sciences
Subject Category: Science & Technology - Other Topics
Document Delivery Number: AD6GL
Unique Article Identifier: WOS:000333355300019
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