학제간연구 | Interdisciplinary Studies in Gambling | 跨学科研究
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- Article] Disposition of methylprednisolone acetate in plasma, urine, and synovial fluid following intra-articular administration to exercised thoroughbred horses
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DocNo of ILP: 75
Doc. Type: Article
Title: Disposition of methylprednisolone acetate in plasma, urine, and synovial fluid following intra-articular administration to exercised thoroughbred horses
Authors: Knych, HK; Harrison, LM; Casbeer, HC; McKemie, DS
Full Name of Authors: Knych, H. K.; Harrison, L. M.; Casbeer, H. C.; McKemie, D. S.
Keywords by Author:
Keywords Plus: DEGENERATIVE JOINT DISEASE; ENDOGENOUS HYDROCORTISONE; PHARMACOKINETICS; SECRETION
Abstract: Methylprednisolone acetate (MPA) is commonly administered to performance horses, and therefore, establishing appropriate withdrawal times prior to performance is critical. The objectives of this study were to describe the plasma pharmacokinetics of MPA and time-related urine and synovial fluid concentrations following intra-articular administration to sixteen racing fit adult Thoroughbred horses. Horses received a single intra-articular administration of MPA (100mg). Blood, urine, and synovial fluid samples were collected prior to and at various times up to 77days postdrug administration and analyzed using tandem liquid chromatography-mass spectrometry (LC-MS/MS). Maximum measured plasma MPA concentrations were 6.06 +/- 1.57 at 0.271days (6.5h; range: 5.0-7.92h) and 6.27 +/- 1.29ng/mL at 0.276days (6.6h; range: 4.03-12.0h) for horses that had synovial fluid collected (group 1) and those that did not (group 2), respectively. The plasma terminal half-life was 1.33 +/- 0.80 and 0.843 +/- 0.414days for groups 1 and 2, respectively. MPA was undetectable by day 6.25 +/- 2.12 (group 1) and 4.81 +/- 2.56 (group 2) in plasma and day 17 (group 1) and 14 (group 2) in urine. MPA concentrations in synovial fluid remained above the limit of detection (LOD) for up to 77days following intra-articular administration, suggesting that plasma and urine concentrations are not a good indicator of synovial fluid concentrations.
Cate of OECD: Basic medicine
Year of Publication: 2014
Business Area: other
Detail Business: medicine & science
Country: USA
Study Area:
Name of Journal: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
Language: English
Country of Authors: [Knych, H. K.; Casbeer, H. C.; McKemie, D. S.] Univ Calif Davis, Sch Vet Med, KL Maddy Equine Analyt Chem Lab, Davis, CA 95616 USA; [Knych, H. K.] Univ Calif Davis, Sch Vet Med, Dept Vet Mol Biosci, Davis, CA 95616 USA; [Harrison, L. M.] Willow Oak Equine, Woodland, CA USA
Press Adress: Knych, HK (reprint author), Univ Calif Davis, Sch Vet Med, KL Maddy Equine Analyt Chem Lab, West Hlth Sci Dr, Davis, CA 95616 USA.
Email Address: hkknych@ucdavis.edu
Citaion:
Funding: Racing Medication and Testing Consortium; California Horse Racing Board
Lists of Citation: AUER JA, 1981, VET SURG, V10, P80, DOI 10.1111/j.1532-950X.1981.tb00635.x; AUTEFAGE A, 1986, EQUINE VET J, V18, P193; Ferguson D. C., 2009, VET PHARM THERAPEUTI, P771; Frisbie DD, 1997, EQUINE VET J, V29, P349; Genovese R. L., 1983, P S EFF US CORT VET, P56; Knych H. K., 2011, P AM ASS EQUINE PRAC, V57, P84; Knych H. K., 2013, EQUINE VET J, DOI 10. 1111/evj.12059; Lillich JD, 1996, AM J VET RES, V57, P187; MCILWRAITH CW, 1982, J AM VET MED ASSOC, V180, P239; McIlwraith C. W., 1989, COMP CONT EDUC PRACT, V11, P1287; Menendez MI, 2012, AM J VET RES, V73, P1453, DOI 10.2460/ajvr.73.9.1453; Soma LR, 2006, AM J VET RES, V67, P654, DOI 10.2460/ajvr.67.4.654
Number of Citaion: 12
Publication: WILEY-BLACKWELL
City of Publication: HOBOKEN
Address of Publication: 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
ISSN: 0140-7783
29-Character Source Abbreviation: J VET PHARMACOL THER
ISO Source Abbreviation: J. Vet. Pharmacol. Ther.
Volume: 37
Version: 2
Start of File: 125
End of File: 132
DOI: 10.1111/jvp.12070
Number of Pages: 8
Web of Science Category: Pharmacology & Pharmacy; Veterinary Sciences
Subject Category: Pharmacology & Pharmacy; Veterinary Sciences
Document Delivery Number: AC2DE
Unique Article Identifier: WOS:000332307100002
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