학제간연구 | Interdisciplinary Studies in Gambling | 跨学科研究
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- Article] Worldwide frequency distribution of the 'Gait keeper' mutation in the DMRT3 gene
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DocNo of ILP: 69
Doc. Type: Article
Title: Worldwide frequency distribution of the 'Gait keeper' mutation in the DMRT3 gene
Authors: Promerova, M; Andersson, LS; Juras, R; Penedo, MCT; Reissmann, M; Tozaki, T; Bellone, R; Dunner, S; Horin, P; Imsland, F; Imsland, P; Mikko, S; Modry, D; Roed, KH; Schwochow, D; Vega-Pla, JL; Mehrabani-Yeganeh, H; Yousefi-Mashouf, N; Cothran, EG; Lindgren, G; Andersson, L
Full Name of Authors: Promerova, M.; Andersson, L. S.; Juras, R.; Penedo, M. C. T.; Reissmann, M.; Tozaki, T.; Bellone, R.; Dunner, S.; Horin, P.; Imsland, F.; Imsland, P.; Mikko, S.; Modry, D.; Roed, K. H.; Schwochow, D.; Vega-Pla, J. L.; Mehrabani-Yeganeh, H.; Yousefi-Mashouf, N.; Cothran, E. G.; Lindgren, G.; Andersson, L.
Keywords by Author: ambling; domestication; horse; locomotion; pace; running walk
Keywords Plus: HORSE BREEDS; SOFTWARE; SEX
Abstract: For centuries, domestic horses have represented an important means of transport and served as working and companion animals. Although their role in transportation is less important today, many horse breeds are still subject to intense selection based on their pattern of locomotion. A striking example of such a selected trait is the ability of a horse to perform additional gaits other than the common walk, trot and gallop. Those could be four-beat ambling gaits, which are particularly smooth and comfortable for the rider, or pace, used mainly in racing. Gaited horse breeds occur around the globe, suggesting that gaitedness is an old trait, selected for in many breeds. A recent study discovered that a nonsense mutation in DMRT3 has a major impact on gaitedness in horses and is present at a high frequency in gaited breeds and in horses bred for harness racing. Here, we report a study of the worldwide distribution of this mutation. We genotyped 4396 horses representing 141 horse breeds for the DMRT3 stop mutation. More than half (2749) of these horses also were genotyped for a SNP situated 32kb upstream of the DMRT3 nonsense mutation because these two SNPs are in very strong linkage disequilibrium. We show that the DMRT3 mutation is present in 68 of the 141 genotyped horse breeds at a frequency ranging from 1% to 100%. We also show that the mutation is not limited to a geographical area, but is found worldwide. The breeds with a high frequency of the stop mutation (>50%) are either classified as gaited or bred for harness racing.
Cate of OECD: Animal and dairy science
Year of Publication: 2014
Business Area: other
Detail Business: medicine & science
Country: USA
Study Area:
Name of Journal: ANIMAL GENETICS
Language: English
Country of Authors: [Promerova, M.; Imsland, F.; Andersson, L.] Uppsala Univ, Dept Med Biochem & Microbiol, SE-75123 Uppsala, Sweden; [Andersson, L. S.; Mikko, S.; Schwochow, D.; Lindgren, G.; Andersson, L.] Swedish Univ Agr Sci, Dept Anim Breeding & Genet, SE-75007 Uppsala, Sweden; [Juras, R.; Cothran, E. G.] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Integrat Biosci, College Stn, TX 77843 USA; [Penedo, M. C. T.] Univ Calif Davis, Sch Vet Med, Vet Genet Lab, Davis, CA 95616 USA; [Reissmann, M.] Humboldt Univ, Fac Agr & Hort, D-10115 Berlin, Germany; [Tozaki, T.] Lab Racing Chem, Genet Anal Dept, Utsunomiya, Tochigi 3200851, Japan; [Bellone, R.] Univ Tampa, Dept Biol, Tampa, FL 33606 USA; [Dunner, S.] Univ Complutense Madrid, Fac Vet, E-28040 Madrid, Spain; [Horin, P.] Univ Vet & Pharmaceut Sci, CEITEC, Inst Anim Genet, Brno 61242, Czech Republic; [Imsland, P.] Menntaskolinn Hamrahlid, IS-105 Reykjavik, Iceland; [Modry, D.] Univ Vet & Pharmaceut Sci, CEITEC, Fac Vet Med, Dept Pathol & Parasitol, Brno 61242, Czech Republic; [Modry, D.] Acad Sci Czech Republic, Inst Parasitol, Ctr Biol, Vvi, Ceske Budejovice 61242, Czech Republic; [Roed, K. H.] Norwegian Sch Vet Sci, Dept Basic Sci & Aquat Med, N-0033 Oslo, Norway; [Vega-Pla, J. L.] Cria Caballar Fuerzas Armadas, Lab Invest Aplicada, Cordoba 14080, Spain; [Mehrabani-Yeganeh, H.; Yousefi-Mashouf, N.] Univ Tehran, Dept Anim Sci, Tehran 54500, Iran
Press Adress: Andersson, L (reprint author), Uppsala Univ, Dept Med Biochem & Microbiol, Box 582, SE-75123 Uppsala, Sweden.
Email Address: leif.andersson@imbim.uu.se
Citaion:
Funding: Knut and Alice Wallenberg Foundation
Lists of Citation: Andersson LS, 2012, NATURE, V488, P642, DOI 10.1038/nature11399; Bateson W, 1907, SCIENCE, V26, P908, DOI 10.1126/science.26.678.908; DIEPENBROEK M, 2000, PANMAP; Excoffier L, 2005, EVOL BIOINFORM, V1, P47; HENDRICKS B, 1995, INT ENCY HORSE BREED; Hong CS, 2007, DEV BIOL, V310, P1, DOI 10.1016/j.ydbio.2007.07.035; Librado P, 2009, BIOINFORMATICS, V25, P1451, DOI 10.1093/bioinformatics/btp187; Luis C, 2006, J HERED, V97, P107, DOI 10.1093/jhered/esj020; Nicodemus MC, 2003, APPL ANIM BEHAV SCI, V80, P133, DOI 10.1016/S0168-1591(02)00219-8; Orlando L, 2013, NATURE, V499, P74, DOI 10.1038/nature12323; Raymond CS, 1998, NATURE, V391, P691, DOI 10.1038/35618; RENDERS E, 1984, NATURE, V308, P179, DOI 10.1038/308179a0; Robilliard JJ, 2007, J EXP BIOL, V210, P187, DOI 10.1242/jeb.02611; Rodero A., 1992, Archivos de Zootecnia, V41, P383; Vega-Pla JL, 2005, EAAP PUBLIC, P167; 1946, ISLENDINGA SOGUR
Number of Citaion: 16
Publication: WILEY-BLACKWELL
City of Publication: HOBOKEN
Address of Publication: 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
ISSN: 0268-9146
29-Character Source Abbreviation: ANIM GENET
ISO Source Abbreviation: Anim. Genet.
Volume: 45
Version: 2
Start of File: 274
End of File: 282
DOI: 10.1111/age.12120
Number of Pages: 9
Web of Science Category: Agriculture, Dairy & Animal Science; Genetics & Heredity
Subject Category: Agriculture; Genetics & Heredity
Document Delivery Number: AB9UA
Unique Article Identifier: WOS:000332140000014
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