학제간연구 | Interdisciplinary Studies in Gambling | 跨学科研究
- date : 2015-05-20 01:10|hit : 2123
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- Article] Amphetamine Sensitization Alters Reward Processing in the Human Striatum and Amygdala
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DocNo of ILP: 47
Doc. Type: Article
Title: Amphetamine Sensitization Alters Reward Processing in the Human Striatum and Amygdala
Authors: O'Daly, OG; Joyce, D; Tracy, DK; Azim, A; Stephan, KE; Murray, RM; Shergill, SS
Full Name of Authors: O'Daly, Owen G.; Joyce, Daniel; Tracy, Derek K.; Azim, Adnan; Stephan, Klaas E.; Murray, Robin M.; Shergill, Sukhwinder S.
Keywords by Author:
Keywords Plus: POSITRON-EMISSION-TOMOGRAPHY; INDUCED DOPAMINE RELEASE; COCAINE-SEEKING BEHAVIOR; CENTER INVENTORY ARCI; NUCLEUS-ACCUMBENS; ORBITOFRONTAL CORTEX; INCENTIVE-SENSITIZATION; EXTRACELLULAR DOPAMINE; BASOLATERAL AMYGDALA; DECISION-MAKING
Abstract: Dysregulation of mesolimbic dopamine transmission is implicated in a number of psychiatric illnesses characterised by disruption of reward processing and goal-directed behaviour, including schizophrenia, drug addiction and impulse control disorders associated with chronic use of dopamine agonists. Amphetamine sensitization (AS) has been proposed to model the development of this aberrant dopamine signalling and the subsequent dysregulation of incentive motivational processes. However, in humans the effects of AS on the dopamine-sensitive neural circuitry associated with reward processing remains unclear. Here we describe the effects of acute amphetamine administration, following a sensitising dosage regime, on blood oxygen level dependent (BOLD) signal in dopaminoceptive brain regions during a rewarded gambling task performed by healthy volunteers. Using a randomised, double-blind, parallel-groups design, we found clear evidence for sensitization to the subjective effects of the drug, while rewarded reaction times were unchanged. Repeated amphetamine exposure was associated with reduced dorsal striatal BOLD signal during decision making, but enhanced ventromedial caudate activity during reward anticipation. The amygdala BOLD response to reward outcomes was blunted following repeated amphetamine exposure. Positive correlations between subjective sensitization and changes in anticipation-and outcome-related BOLD signal were seen for the caudate nucleus and amygdala, respectively. These data show for the first time in humans that AS changes the functional impact of acute stimulant exposure on the processing of reward-related information within dopaminoceptive regions. Our findings accord with pathophysiological models which implicate aberrant dopaminergic modulation of striatal and amygdala activity in psychosis and drug-related compulsive disorders.
Cate of OECD: Other natural sciences
Year of Publication: 2014
Business Area: other
Detail Business: medicine & science
Country: USA
Study Area:
Name of Journal: PLOS ONE
Language: English
Country of Authors: [O'Daly, Owen G.; Joyce, Daniel; Tracy, Derek K.; Azim, Adnan; Shergill, Sukhwinder S.] Kings Coll London, Inst Psychiat, Dept Psychosis Studies, Cognit Schizophrenia & Imaging Lab, London, England; [O'Daly, Owen G.] Kings Coll London, Inst Psychiat, Ctr Neuroimaging Sci, Dept Neuroimaging, London, England; [Tracy, Derek K.] Oxleas NHS Fdn Trust, London, England; [Stephan, Klaas E.] Univ Zurich, Dept Econ, Lab Social & Neural Syst Res, Zurich, Switzerland; [Stephan, Klaas E.] UCL, Inst Neurol, Wellcome Trust Ctr Neuroimaging, London, England; [Murray, Robin M.] Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London, England; [Shergill, Sukhwinder S.] South London & Maudsley NHS Fdn, Natl Psychosis Unit, London, England
Press Adress: O'Daly, OG (reprint author), Kings Coll London, Inst Psychiat, Dept Psychosis Studies, Cognit Schizophrenia & Imaging Lab, London, England.
Email Address: o.o'daly@kcl.ac.uk
Citaion:
Funding: Wellcome grant
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Number of Citaion: 116
Publication: PUBLIC LIBRARY SCIENCE
City of Publication: SAN FRANCISCO
Address of Publication: 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
ISSN: 1932-6203
29-Character Source Abbreviation: PLOS ONE
ISO Source Abbreviation: PLoS One
Volume: 9
Version: 4
Start of File:
End of File:
DOI: 10.1371/journal.pone.0093955
Number of Pages: 11
Web of Science Category: Multidisciplinary Sciences
Subject Category: Science & Technology - Other Topics
Document Delivery Number: AE9PC
Unique Article Identifier: WOS:000334339000060
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