학제간연구 | Interdisciplinary Studies in Gambling | 跨学科研究
- date : 2015-05-20 01:10|hit : 1589
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- Article] Vascular perfusion of the dorsal and palmar condyles of the equine third metacarpal bone
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DocNo of ILP: 37
Doc. Type: Article
Title: Vascular perfusion of the dorsal and palmar condyles of the equine third metacarpal bone
Authors: Alber, MT; Brown, MP; Merritt, KA; Trumble, TN
Full Name of Authors: Alber, M. T.; Brown, M. P.; Merritt, K. A.; Trumble, T. N.
Keywords by Author: palmar osteochondral disease; fetlock; third metacarpal bone; osteoarthritis; horse; vascular perfusion
Keywords Plus: SUBCHONDRAL BONE; CALCIFIED CARTILAGE; METATARSAL BONES; DISTAL CONDYLES; OSTEOCHONDROSIS; JOINT; MICROVASCULATURE; ARTHROSIS; INJURIES; HORSE
Abstract: Reasons for performing study Palmar osteochondral disease (POD) is an overload arthrosis that commonly affects fetlock joints of racing Thoroughbreds (TB) but the aetiopathogenesis of the disease has not been well defined. Objectives The aim of this study was to compare India ink perfusion in the dorsal and palmar condyles of the third metacarpal bone (McIII) in both passively flexed and maximally extended fetlock joints from paired equine cadaver limbs. Study design Descriptive cadaver study comparing perfusion of condyles of McIII in paired cadaver limbs in flexion (control group) and maximal extension (intervention group). Methods Pairs of forelimbs were acquired from 5 TB horses subjected to euthanasia for reasons unrelated to lameness. Limb pairs were perfused intra-arterially with India ink and then randomly assigned to passive flexion or maximal extension of the fetlock joint. Limbs were sectioned sagittally in 3 mm sections through the fetlock and 12 sections per limb processed using a modified tissue-clearing technique. Sections were subsequently digitally imaged and bone perfusion evaluated with image analysis software. Results Greater perfusion of the dorsal condyle than of palmar condyle was observed in 78% of sections from limbs in passive flexion and 92% of maximally extended sections. Perfusion to the palmar aspect of the condyle was significantly decreased (P<0.0001) when the limbs were placed in maximal extension compared to passive flexion. Conclusions The palmar condyle of McIII had less perfusion than the dorsal condyle when the fetlock joint was in passive flexion and this difference was exacerbated by maximal extension. Based on the anatomical location of POD lesions, perfusion differences between the dorsal and palmar condyles of McIII may be associated with development of these lesions.
Cate of OECD: Veterinary science
Year of Publication: 2014
Business Area: other
Detail Business: medicine & science
Country: USA
Study Area:
Name of Journal: EQUINE VETERINARY JOURNAL
Language: English
Country of Authors: [Alber, M. T.; Brown, M. P.; Merritt, K. A.] Univ Florida, Coll Vet Med, Dept Large Anim Clin Sci, Gainesville, FL 32611 USA; [Trumble, T. N.] Univ Minnesota, Coll Vet Med, Dept Vet Populat Med, Minneapolis, MN 55455 USA
Press Adress: Brown, MP (reprint author), Univ Florida, Coll Vet Med, Dept Large Anim Clin Sci, Gainesville, FL 32611 USA.
Email Address: brownmu@ufl.edu
Citaion:
Funding: University of Florida College of Veterinary Medicine; Merck-Merial Veterinary Scholars Programme
Lists of Citation: ARNOCZKY SP, 1979, J BONE JOINT SURG AM, V61, P1221; Barr ED, 2009, EQUINE VET J, V41, P366, DOI 10.2746/042516409X368372; Bebchuk TN, 2000, VET SURG, V29, P128, DOI 10.1111/j.1532-950X.2000.00128.x; Boyde A, 2011, EUR CELLS MATER, V21, P470; COLAHAN P, 1988, AM J VET RES, V49, P1560; Norrdin RW, 1999, BONE, V24, P109, DOI 10.1016/S8756-3282(98)00157-4; Norrdin RW, 1998, BONE, V22, P133, DOI 10.1016/S8756-3282(97)00253-6; Olstad K, 2008, EQUINE VET J, V40, P30, DOI 10.2746/042516407X239836; Pool RR, 1996, JOINT DIS HORSE, P87; POOL RR, 1990, VET CLIN N AM-EQUINE, V6, P1; Riggs CM, 1999, EQUINE VET J, V31, P130; Riggs CM, 1999, EQUINE VET J, V31, P140; Rosner B., 2006, FUNDAMENTALS BIOSTAT, P325; Santschi EM, 2008, VET CLIN N AM-EQUINE, V24, P117, DOI 10.1016/j.cveq.2007.11.011; TRUMBLE TN, 1995, AM J VET RES, V56, P720; Ytrehus B, 2004, BONE, V34, P454, DOI 10.1016/j.bone.2003.07.011
Number of Citaion: 16
Publication: WILEY-BLACKWELL
City of Publication: HOBOKEN
Address of Publication: 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
ISSN: 0425-1644
29-Character Source Abbreviation: EQUINE VET J
ISO Source Abbreviation: Equine Vet. J.
Volume: 46
Version: 3
Start of File: 370
End of File: 374
DOI: 10.1111/evj.12136
Number of Pages: 5
Web of Science Category: Veterinary Sciences
Subject Category: Veterinary Sciences
Document Delivery Number: AE6QQ
Unique Article Identifier: WOS:000334119000021
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