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- Article] Dyslipidaemia among renal transplant recipients: cyclosporine versus tacrolimus
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DocNo of ILP: 33
Doc. Type: Article
Title: Dyslipidaemia among renal transplant recipients: cyclosporine versus tacrolimus
Authors: Fazal, MA; Idrees, MK; Akhtar, SF
Full Name of Authors: Fazal, Muhammad Asim; Idrees, Muhammad Khalid; Akhtar, Syed Fazal
Keywords by Author: Dyslipidaemia; Cyclosporine; Tacrolimus; Renal transplant; Lipid
Keywords Plus: KIDNEY-TRANSPLANTATION; RISK-FACTORS; FOLLOW-UP; 1ST YEAR; INHIBITORS; CONVERSION; MORTALITY; DIALYSIS; THERAPY
Abstract: Objectives: To compare new onset dyslipidaemia in live-related renal transplant recipients taking cyclosporine versus tacrolimus after 3 months of therapy. Methods: The randomised controlled trial was conducted at the Sindh Institute of Urology and Transplantation (SIUT) Karachi, from September 2010 to April 2011, and included 182 End Stage Renal Disease patients on maintenance haemodialysis with pre-transplant normal lipid profile. The patients, who had live-related renal transplant, were randomly allocated to two equal groups using lottery. Group A received cyclosporine (3mg/kg) and group B was treated with tacrolimus (0.1mg/kg). All patients had pre-transplant fasting lipid profile checked when they were on maintenance haemodialysis and 3 months after renal transplantation. Serum fasting lipid profile was collected by taking 5ml blood by venipuncture after an overnight fast of 9-12 hours. SPSS 10 was used for statistical analyses. Results: Of the 182 patients, 144(79.1%) were males and 38(20.9%) were females. The overall mean age was 30.18 +/- 9.57 years, and the mean weight was 54.41 +/- 11.144kg. Significant difference was not observed between the two groups regarding age and weight of the patients. Dyslipidaemia was found in 115(63.2%) subjects; 61(67%) in group A and 54(59.3%) in group B. There was no statistical difference (p=0.28) when comparison was done after 3 months of therapy. Conclusions: The occurrence of new onset hyperlipidaemia is similar in renal transplant recipients receiving either cyclosporine or tacrolimus in first 3 months post-transplant, but there is room for more research in this field as dyslipidaemia following successful renal transplantation is a frequent and persistent complication.
Cate of OECD: Clinical medicine
Year of Publication: 2014
Business Area: lottery
Detail Business: lottery
Country: Pakistan
Study Area:
Name of Journal: JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
Language: English
Country of Authors: [Fazal, Muhammad Asim; Idrees, Muhammad Khalid; Akhtar, Syed Fazal] Sindh Inst Urol & Transplantat, Dept Nephrol, Karachi, Pakistan
Press Adress: Idrees, MK (reprint author), Sindh Inst Urol & Transplantat, Dept Nephrol, Karachi, Pakistan.
Email Address: drkhalid37@gmail.com
Citaion:
Funding:
Lists of Citation: CIFTCI HS, 2012, IND J CLIN BIOCH, V28, P164; Claes K, 2012, NEPHROL DIAL TRANSPL, V27, P850, DOI 10.1093/ndt/gfr238; Collins AJ, 2009, CLIN J AM SOC NEPHRO, V4, pS5, DOI 10.2215/CJN.05980809; Dumler F, 2007, J RENAL NUTR, V17, P97, DOI 10.1053/j.jrn.2006.10.017; Ghisdal L, 2008, TRANSPL INT, V21, P146, DOI 10.1111/j.1432-2277.2007.00589.x; GHNAIMAT M, 2006, JRMS, V13, P10; KAHAN BD, 1989, NEW ENGL J MED, V321, P1725; Kanbay M, 2006, TRANSPLANT P, V38, P502, DOI 10.1016/j.transproceed.2005.12.052; Kramer BK, 2005, NEPHROL DIAL TRANSPL, V20, P968, DOI 10.1093/ndt/gfh739; Ligtenberg G, 2001, J AM SOC NEPHROL, V12, P368; MOHAMMAD HF, 2012, GLOBAL J MED RES, V12, P5; NAVANEETHAN SD, 2009, COCHRANE DB SYST REV, V15, P5019; Neipp M, 2006, TRANSPLANTATION, V81, P1640, DOI 10.1097/01.tp.0000226070.74443.fb; OJHA JP, 2012, CLIN QUERIES NEPHROL, V1, P191; *OPTN, 2011, OPTN SRTR 2010 ANN D; Perrea DN, 2008, INT UROL NEPHROL, V40, P521, DOI 10.1007/s11255-007-9266-y; POURMAND G, 2010, INT J ORG TRANSPLANT, V1, P131; Prakash J, 2012, Indian J Nephrol, V22, P264, DOI 10.4103/0971-4065.101245; Rabbat CG, 2000, J AM SOC NEPHROL, V11, P917; Razeghi E, 2011, EXP CLIN TRANSPLANT, V9, P230; Rizvi SAH, 2010, CLIN NEPHROL, V74, pS142; Rostaing L, 2010, J NEPHROL, V23, P133; Rostaing L, 2012, TRANSPL INT, V25, P391, DOI 10.1111/j.1432-2277.2011.01409.x; Spinelli GA, 2011, TRANSPL P, V43, P3730, DOI 10.1016/j.transproceed.2011.08.074; Younas N, 2010, BMC NEPHROL, V11, DOI 10.1186/1471-2369-11-5
Number of Citaion: 25
Publication: PAKISTAN MEDICAL ASSOC
City of Publication: KARACHI
Address of Publication: PMA HOUSE, AGA KHAN III RD, KARACHI, 00000, PAKISTAN
ISSN: 0030-9982
29-Character Source Abbreviation: J PAK MED ASSOC
ISO Source Abbreviation: J. Pak. Med. Assoc.
Volume: 64
Version: 5
Start of File: 496
End of File: 499
DOI:
Number of Pages: 4
Web of Science Category: Medicine, General & Internal; Medicine, Research & Experimental
Subject Category: General & Internal Medicine; Research & Experimental Medicine
Document Delivery Number: AF0GT
Unique Article Identifier: WOS:000334393000003
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