학제간연구 | Interdisciplinary Studies in Gambling | 跨学科研究
- date : 2015-05-20 01:10|hit : 1827
-
- Article] Interstitial Cajal-like cells in human gallbladder
-
DocNo of ILP: 4191
Doc. Type: Article
Title: Interstitial Cajal-like cells in human gallbladder
Authors: Hinescu, ME; Ardeleanu, C; Gherghiceanu, M; Popescu, LM
Full Name of Authors: Hinescu, Mihail E.; Ardeleanu, Carmen; Gherghiceanu, Mihaela; Popescu, Laurentziu M.
Keywords by Author: interstitial cells of Cajal; CD117/c-kit; CD34; vimentin; human gallbladder; immunohistochemistry
Keywords Plus: GASTROINTESTINAL STROMAL TUMORS; SLOW TRANSIT CONSTIPATION; C-KIT; COMPARATIVE MORPHOLOGY; TARGETED THERAPY; HUMAN MYOMETRIUM; FALLOPIAN-TUBE; BILIARY-TRACT; HUMAN UTERUS; CULTURE
Abstract: We describe here an interstitial Cajal-like cell type (ICLC) in human gallbladder, resembling the archetypal enteric interstitial cells of Cajal. Gallbladder ICLC were demonstrated in fresh preparations (tissue cryosections) using methylene-blue, and fixed specimens in Epon semi-thin sections stained with toluidine blue or transmission electron microscopy (TEM). The positive diagnosis of gallbladder ICLC was further verified by immunohistochemistry: CD117/c-kit, CD34, and another 16 antigens: vimentin, desmin, nestin, alpha-smooth muscle actin, NK-1, S-100, PGP-9.5, tau protein, chromogranin A, NSE, GFAP, CD1a, CD62-P, CD68, estrogen and progesterone receptors. Double immunostaining was performed for CD117, CD34 and CD117 and nestin, respectively. In fresh specimens, the spatial density of gallbladder ICLC was 100-110 cells/mm(2). ICLC mainly appeared beneath the epithelium and in muscularis (about 7%, and similar to 5%, respectively). In toto, ICLC represent in gallbladder similar to 5.5% of subepithelial cells. TEM showed that diagnostic criteria were fulfilled by ICLC. Moreover, TEM indicated that the main ultrastructural distinctive feature for ICLC, the cell processes, develop into the characteristic shape at a relatively early stage of development. It remains to be established if, in humans, ICLC are involved in gallbladder (dis)functions (e.g. pace-making, secretion (auto-, juxta- and/or paracrine), intercellular signaling, or stone formation).
Cate of OECD: Biological sciences
Year of Publication: 2007
Business Area: other
Detail Business: medicine & science
Country: Netherlands
Study Area:
Name of Journal: JOURNAL OF MOLECULAR HISTOLOGY
Language: English
Country of Authors: Carol Davila Univ Med & Pharm, Dept Cellular & Mol Med, Bucharest 35, Romania; Victor Babes Natl Inst Pathol, Bucharest, Romania
Press Adress: Popescu, LM (reprint author), Carol Davila Univ Med & Pharm, Dept Cellular & Mol Med, POB 35-29, Bucharest 35, Romania.
Email Address: lpopescu@jcmm.org
Citaion:
Funding:
Lists of Citation: Bobryshev YV, 2005, CELL TISSUE RES, V321, P45, DOI 10.1007/s00441-004-1061-9; BUSSOLATI G, 1983, J HISTOCHEM CYTOCHEM, V31, P1419; Bussolati G, 2005, VIRCHOWS ARCH, V447, P907, DOI 10.1007/s00428-005-0083-3; CAJAL RS, 1911, HISTOLOGIE SYSTEM NE; Ciontea SM, 2005, J CELL MOL MED, V9, P407, DOI 10.1111/j.1582-4934.2005.tb00366.x; Cretoiu D, 2006, J CELL MOL MED, V10, P789, DOI 10.1111/j.1582-4934.2006.tb00438.x; Dray X, 2007, J AM COLL SURGEONS, V204, P13, DOI 10.1016/j.jamcollsurg.2006.09.008; Faussone-Pellegrini MS, 2006, CELL TISSUE RES, V325, P211, DOI 10.1007/s00441-006-0174-8; Faussone-Pellegrini MS, 2006, J CELL MOL MED, V10, P20, DOI 10.1111/j.1582-4934.2006.tb00288.x; Faussone-Pellegrini MS, 2006, J CELL MOL MED, V10, P511, DOI 10.1111/j.1582-4934.2006.tb00416.x; Faussone-Pellegrini MS, 1999, MICROSC RES TECHNIQ, V47, P248, DOI 10.1002/(SICI)1097-0029(19991115)47:4<248::AID-JEMT4>3.0.CO;2-W; Frossard Jean Louis, 2005, J Hepatol, V42, P782, DOI 10.1016/j.jhep.2005.02.008; Furihata M, 2005, PATHOL RES PRACT, V201, P609, DOI 10.1016/j.prp.2005.04.01; Grimbaldeston MA, 2005, AM J PATHOL, V167, P835, DOI 10.1016/S0002-9440(10)62055-X; Hakimian R, 2004, JAMA-J AM MED ASSOC, V292, P2500, DOI 10.1001/jama.292.20.2500; Harhun MI, 2005, J CELL MOL MED, V9, P232, DOI 10.1111/j.1582-4934.2005.tb00352.x; Heinrich MC, 2005, J SURG ONCOL, V90, P195, DOI 10.1002/jso.20230; Hinescu M E, 2005, J Cell Mol Med, V9, P972, DOI 10.1111/j.1582-4934.2005.tb00394.x; Popescu LM, 2005, J CELL MOL MED, V9, P479, DOI 10.1111/j.1582-4934.2005.tb00376.x; Hinescu ME, 2006, J CELL MOL MED, V10, P243, DOI 10.1111/j.1582-4934.2006.tb00306.x; Hopwood D, 1997, MICROSC RES TECHNIQ, V38, P631, DOI 10.1002/(SICI)1097-0029(19970915)38:6<631::AID-JEMT7>3.0.CO;2-H; HSU SM, 1981, J HISTOCHEM CYTOCHEM, V29, P577; Huizinga JD, 2005, J CELL MOL MED, V9, P468, DOI 10.1111/j.1582-4934.2005.tb00372.x; Huizinga JD, 1997, TRENDS PHARMACOL SCI, V18, P393, DOI 10.1016/S0165-6147(97)01108-5; ISOZAKI K, 1995, GASTROENTEROLOGY, V109, P456, DOI 10.1016/0016-5085(95)90333-X; Komuro T, 1999, MICROSC RES TECHNIQ, V47, P267, DOI 10.1002/(SICI)1097-0029(19991115)47:4<267::AID-JEMT5>3.0.CO;2-O; Kubota M, 2005, BRAIN DEV-JPN, V27, P447, DOI 10.1016/j.braindev.2004.10.006; Lang RJ, 2005, J CELL MOL MED, V9, P543, DOI 10.1111/j.1582-4934.2005.tb00487.x; Langner C, 2004, EJSO, V30, P847, DOI 10.1016/j.ejso.2004.05.002; Lardon J, 2004, HEPATOLOGY, V39, P1499, DOI 10.1002/hep.20213; LAVOIE BB, 2007, J PHYSL, V597, P487; Lee H, 2002, J CLIN PATHOL, V55, P236; Lyford GL, 2002, GUT, V51, P496, DOI 10.1136/gut.51.4.496; MAEDA H, 1992, DEVELOPMENT, V116, P369; McCloskey KD, 2002, CELL TISSUE RES, V310, P77, DOI 10.1007/s00441-002-0623-y; Mendoza-Marin M, 2002, ARCH PATHOL LAB MED, V126, P481; Miller K, 2002, THEORY PRACTICE HIST, P421; Nakanuma Y, 1997, MICROSC RES TECHNIQ, V39, P71, DOI 10.1002/(SICI)1097-0029(19971001)39:1<71::AID-JEMT6>3.0.CO;2-2; OldhamOtt CK, 1997, MICROSC RES TECHNIQ, V38, P571, DOI 10.1002/(SICI)1097-0029(19970915)38:6<571::AID-JEMT3>3.0.CO;2-I; Ortiz-Hidalgo C, 2000, AM J SURG PATHOL, V24, P1420, DOI 10.1097/00000478-200010000-00013; Park JK, 2004, J KOREAN MED SCI, V19, P763; Parr EJ, 2003, GASTROENTEROLOGY, V124, pA347, DOI 10.1016/S0016-5085(03)81751-1; Popescu LM, 2005, J CELL MOL MED, V9, P714, DOI 10.1111/j.1582-4934.2005.tb00502.x; Popescu LM, 2005, J CELL MOL MED, V9, P169, DOI 10.1111/j.1582-4934.2005.tb00347.x; Popescu L M, 2005, J Cell Mol Med, V9, P476, DOI 10.1111/j.1582-4934.2005.tb00375.x; Popescu LM, 2007, ANN NY ACAD SCI, V1101, P139, DOI 10.1196/annals.1389.022; Popescu LM, 2006, EUR J PHARMACOL, V546, P177, DOI 10.1016/j.ejphar.2006.06.068; Popescu LM, 2006, J CELL MOL MED, V10, P429, DOI 10.1111/j.1582-4934.2006.tb00410.x; Porcher C, 2002, AM J GASTROENTEROL, V97, P118; Radu E, 2005, J CELL MOL MED, V9, P748, DOI 10.1111/j.1582-4934.2005.tb00509.x; Robinson TL, 2000, AM J PATHOL, V156, P1157, DOI 10.1016/S0002-9440(10)64984-X; Rumessen JJ, 2001, CELL TISSUE RES, V306, P1, DOI 10.1007/s004410100418; Sanders KM, 2006, J PHYSIOL-LONDON, V576, P721, DOI 10.1113/jphysiol.2006.115279; Sanders KM, 2002, AM J PHYSIOL-GASTR L, V282, pG747, DOI 10.1152/ajpgi.00362.2001; Sergeant GP, 2006, J CELL MOL MED, V10, P280, DOI 10.1111/j.1582-4934.2006.tb00399.x; Shen CN, 2000, NAT CELL BIOL, V2, P879; Solari V, 2003, J UROLOGY, V170, P2420, DOI 10.1097/01.ju.0000097401.03293.f0; Streutker CJ, 2007, HISTOPATHOLOGY, V50, P190, DOI 10.1111/j.1365-2559.2006.02497.x; Sumazaki R, 2004, NAT GENET, V36, P83, DOI 10.1038/ng1273; Sun XM, 2006, SCAND J GASTROENTERO, V41, P1218, DOI 10.1080/00365520600708800; Taguchi T, 2005, EUR J PEDIATR SURG, V15, P153, DOI 10.1055/s-2005-837612; Takahashi M, 2001, CYTOKINE GROWTH F R, V12, P361, DOI 10.1016/S1359-6101(01)00012-0; Thomas MB, 2007, CRIT REV ONCOL HEMAT, V61, P44, DOI 10.1016/j.critrevonc.2006.07.006; Tong WD, 2004, INT J COLORECTAL DIS, V19, P467, DOI 10.1007/s00384-003-0577-x; Vannucchi MG, 1999, MICROSC RES TECHNIQ, V47, P325, DOI 10.1002/(SICI)1097-0029(19991201)47:5<325::AID-JEMT4>3.0.CO;2-C; Ye J, 2006, J CELL MOL MED, V10, P687, DOI 10.2755/jcmm010.003.17
Number of Citaion: 66
Publication: SPRINGER
City of Publication: DORDRECHT
Address of Publication: VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
ISSN: 1567-2379
29-Character Source Abbreviation: J MOL HISTOL
ISO Source Abbreviation: J. Mol. Histol.
Volume: 38
Version: 4
Start of File: 275
End of File: 284
DOI: 10.1007/s10735-007-9099-0
Number of Pages: 10
Web of Science Category: Cell Biology
Subject Category: Cell Biology
Document Delivery Number: 194EX
Unique Article Identifier: WOS:000248328300004
- reply : 0
-
- list
-
- prev
- next