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- Article] Neuropsychological frontal impairments and negative symptoms in schizophrenia
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DocNo of ILP: 4172
Doc. Type: Article
Title: Neuropsychological frontal impairments and negative symptoms in schizophrenia
Authors: Martino, DJ; Bucay, D; Butman, JT; Allegri, RF
Full Name of Authors: Martino, Diego J.; Bucay, Demian; Butman, Judith T.; Allegri, Ricardo F.
Keywords by Author: theory of mind; decision making; gambling
Keywords Plus: PREFRONTAL CORTICAL DYSFUNCTION; 1ST EPISODE SCHIZOPHRENIA; MIND; CORTEX; APATHY; PERFORMANCE; DEFICITS; PEOPLE; BRAIN; SPECTRUM
Abstract: Negative symptoms have been associated with frontal lobe dysfunction in schizophrenia. However, neuropsychological studies that evaluated the correlation between performance in tests sensitive to the dorsolateral prefrontal cortex (DLPFC) and negative symptoms have shown inconsistent results. Growing evidence has appeared that not only the DLPFC but other prefrontal regions could be involved in schizophrenia. We evaluated schizophrenic patients and healthy controls using three "frontal tests": the Wisconsin Card Sorting Test (WCST), the Iowa Gambling Task (GT) and a Theory of Mind test (Faux Pas), and studied the relationship between performance in these tests and negative symptomatology. Schizophrenic patients had worse performance than normal controls on the WCST, GT and Faux Pas test. The severity of the negative symptoms showed a moderate to high correlation with performance in the Faux Pas test. Our findings support the idea that different prefrontal regions could be affected in people with schizophrenia and that the damage to each of these regions could be, at least in part, independent of the damage to the others. Some negative symptoms could be associated with frontal medial cortex dysfunction. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Cate of OECD: Clinical medicine
Year of Publication: 2007
Business Area: gamble
Detail Business: gamble
Country: Ireland
Study Area: regulation, control, mind theory, mind theory, patient, decision, schizo-obsessive
Name of Journal: PSYCHIATRY RESEARCH
Language: English
Country of Authors: AREA Res & Dev Mental Hlth, RA-1425 Buenos Aires, DF, Argentina; Alvear Psychiat Hosp GCBA, Buenos Aires, DF, Argentina; Zubizarreta Hosp GCBA, Memory Res Lab, Buenos Aires, DF, Argentina; Consejo Nacl Invest Cient & Tecn, Natl Res Council, RA-1033 Buenos Aires, DF, Argentina
Press Adress: Martino, DJ (reprint author), AREA Res & Dev Mental Hlth, Gurruchaga 2463,1 C, RA-1425 Buenos Aires, DF, Argentina.
Email Address: diejmartino@yahoo.com.ar
Citaion:
Funding:
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Number of Citaion: 54
Publication: ELSEVIER IRELAND LTD
City of Publication: CLARE
Address of Publication: ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
ISSN: 0165-1781
29-Character Source Abbreviation: PSYCHIAT RES
ISO Source Abbreviation: Psychiatry Res.
Volume: 152
Version: 41673
Start of File: 121
End of File: 128
DOI: 10.1016/j.psychres.2006.03.002
Number of Pages: 8
Web of Science Category: Psychiatry
Subject Category: Psychiatry
Document Delivery Number: 208QH
Unique Article Identifier: WOS:000249333800004
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