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  • ÇÐÁ¦°£¿¬±¸ | Interdisciplinary Studies in Gambling | Î¥学Ρ研ϼ

    date : 2015-05-20 01:10|hit : 1689
    Article] Utilities and disutilities for type 2 diabetes treatment-related attributes
    DocNo of ILP: 4163

    Doc. Type: Article

    Title: Utilities and disutilities for type 2 diabetes treatment-related attributes

    Authors: Matza, LS; Boye, KS; Yurgin, N; Brewster-Jordan, J; Mannix, S; Shorr, JM; Barber, BL

    Full Name of Authors: Matza, Louis S.; Boye, Kristina S.; Yurgin, Nicole; Brewster-Jordan, Jessica; Mannix, Sally; Shorr, Jodi M.; Barber, Beth L.

    Keywords by Author: type 2 diabetes; utility; disutility; standard gamble; weight change; fear of hypoglycemia

    Keywords Plus: QUALITY-OF-LIFE; HEALTH STATE UTILITIES; BODY-MASS INDEX; ATTENTION-DEFICIT/HYPERACTIVITY-DISORDER; INTENSIVE BLOOD-GLUCOSE; STANDARD GAMBLE; METHODOLOGICAL ISSUES; COST-EFFECTIVENESS; CLINICAL-OUTCOMES; GALLSTONE DISEASE

    Abstract: Introduction Although cost-utility analyses are frequently used to estimate treatment outcomes for type 2 diabetes, utilities are not available for key medication-related attributes. The purpose of this study was to identify the utility or disutility of diabetes medication-related attributes (weight change, gastrointestinal side effects, fear of hypoglycemia) that may influence patient preference. Methods Patients with type 2 diabetes in Scotland and England completed standard gamble (SG) interviews to assess utility of hypothetical health states and their own current health state. The EQ-5D, PGWB, and Appraisal of Diabetes Symptoms were administered. Construct validity and differences among health states were examined with correlations, t-tests, and ANOVAs. Results A total of 129 patients (51 Scotland; 78 England) completed interviews. Mean utility of diabetes without complications was 0.89. Greater body weight was associated with disutility, and lower body weight with added utility (e.g., 3% higher = -0.04; 3% lower = +0.02). Gastrointestinal side effects and fear of hypoglycemia were associated with significant disutility (p < 0.001). SG utility of current health (mean = 0.87) demonstrated construct validity through correlations with patient-reported outcome measures (r = 0.08-0.31). Discussion The vignette-based approach was feasible and useful for assessing added utility or disutility of medication-related attributes.

    Cate of OECD: Health sciences

    Year of Publication: 2007

    Business Area: gamble

    Detail Business: gamble

    Country: Netherlands

    Study Area:

    Name of Journal: QUALITY OF LIFE RESEARCH

    Language: English

    Country of Authors: United BioSource Corp, Ctr Hlth Outcomes Res, Bethesda, MD 20814 USA; Eli Lilly & Co, Indianapolis, IN 46285 USA

    Press Adress: Matza, LS (reprint author), United BioSource Corp, Ctr Hlth Outcomes Res, 7101 Wisconsin Ave,Suite 600, Bethesda, MD 20814 USA.

    Email Address: louis.matza@unitedbiosource.com

    Citaion:

    Funding:

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    Number of Citaion: 80

    Publication: SPRINGER

    City of Publication: DORDRECHT

    Address of Publication: VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS

    ISSN: 0962-9343

    29-Character Source Abbreviation: QUAL LIFE RES

    ISO Source Abbreviation: Qual. Life Res.

    Volume: 16

    Version: 7

    Start of File: 1251

    End of File: 1265

    DOI: 10.1007/s11136-007-9226-0

    Number of Pages: 15

    Web of Science Category: Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health

    Subject Category: Health Care Sciences & Services; Public, Environmental & Occupational Health

    Document Delivery Number: 206TT

    Unique Article Identifier: WOS:000249206500015

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