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- Article] Summary health status measures in advanced heart failure: Relationship to clinical variables and outcome
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DocNo of ILP: 4153
Doc. Type: Article
Title: Summary health status measures in advanced heart failure: Relationship to clinical variables and outcome
Authors: Sullivan, MD; Levy, WC; Russo, JE; Crane, B; Spertus, JA
Full Name of Authors: Sullivan, Mark D.; Levy, Wayne C.; Russo, Joan E.; Crane, Barbara; Spertus, John A.
Keywords by Author: health utility; quality of life; prognosis; standard gamble
Keywords Plus: QUALITY-OF-LIFE; SELF-RATED HEALTH; 6-MINUTE WALK; RATING-SCALE; PRIMARY-CARE; QUESTIONNAIRE; SURVIVAL; TRIAL; PREFERENCES; PREDICTION
Abstract: Background: Patient-centered health status measures are important because they capture the patient's perspective on their heart failure, but it is unclear which of these have independent prognostic significance. Methods and Results: A total of 142 consecutive subjects from a specialty heart failure clinic were assessed at baseline with a broad array of clinical, laboratory, and self-report measures including four summary measures of health status. The relationships between these measures and their association with the combined end point of transplantation or death over a mean follow-up of 3 years were examined. In unadjusted analyses, the Kansas City Cardiomyopathy Questionnaire (KCCQ) summary score had the strongest association with the combined end point (HR [for each unit score difference] = 0.98 [0.96-0.991, P = .002). In the adjusted Cox proportional hazards model including all 4 summary measures, the Seattle Heart Failure Score, VO2, Systolic blood pressure, and medical comorbidity, only the Standard Gamble utility remained significantly associated with time to the combined end point (HR [for each 0.01 utility score difference] = 0.98 [0.97-0.99], P = .007). Conclusions: Our study suggests that summary health status measures are simple and significant indicators of prognosis in advanced heart failure patients. The KCCQ summary score summarizes a wide range of clinical variables from the patient's point of view, whereas the standard gamble utility contains important prognostic information not captured in usual clinical variables.
Cate of OECD: Clinical medicine
Year of Publication: 2007
Business Area: other
Detail Business: medicine & science
Country: USA
Study Area:
Name of Journal: JOURNAL OF CARDIAC FAILURE
Language: English
Country of Authors: [Sullivan, Mark D.; Levy, Wayne C.; Russo, Joan E.; Crane, Barbara] Univ Washington, Seattle, WA 98195 USA; [Spertus, John A.] Univ Missouri, Mid Amer Heart Inst, Kansas City, MO USA
Press Adress: Sullivan, MD (reprint author), Univ Washington, Seattle, WA 98195 USA.
Email Address:
Citaion:
Funding:
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Number of Citaion: 41
Publication: CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
City of Publication: PHILADELPHIA
Address of Publication: CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
ISSN: 1071-9164
29-Character Source Abbreviation: J CARD FAIL
ISO Source Abbreviation: J. Card. Fail.
Volume: 13
Version: 7
Start of File: 560
End of File: 568
DOI: 10.1016/j.cardfail.2007.04.001
Number of Pages: 9
Web of Science Category: Cardiac & Cardiovascular Systems
Subject Category: Cardiovascular System & Cardiology
Document Delivery Number: 324FF
Unique Article Identifier: WOS:000257502400008
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