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- Article] Therapy of canine deep pyoderma with cephalexins and immunomodulators
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DocNo of ILP: 4132
Doc. Type: Article
Title: Therapy of canine deep pyoderma with cephalexins and immunomodulators
Authors: Sprucek, R; Svoboda, M; Toman, M; Faldyna, M; Sprucek, F
Full Name of Authors: Sprucek, R.; Svoboda, M.; Toman, M.; Faldyna, M.; Sprucek, F., Jr.
Keywords by Author: cephalexin; Baypamune (R); staphylococcus intermedius; deep pyoderma
Keywords Plus: INFECTIONS; DOGS
Abstract: Pyodermas are among bacterial skin diseases often resisting antibiotic therapy. We therefore examined how the dogs with deep pyoderma (n = 29) respond to therapeutic effect of antibiotic cephalexins(Ceporex((R)) 30 mg center dot kg(-1) p.o., once a day for 9-11 weeks) combined with immunomodulators (Baypamune((R)), once aweek i.m. pro toto). The dogs with the first occurrence of pyoderma (n = 11) were treated by antibiotics alone, whereas the dogs with recurrent pyoderma (n = 18) were treated by either antibiotics alone (n = 8) or antibiotics combined with Baypamune((R)) (n = 10). Of 11 dogs with the first occurrence of disease, 8 (73%) were successfully cured. However, only 5 of them (45%) stayed recovered after a period of two months that elapsed from the completion of therapy. Of the 8 dogs with recurrent pyoderma treated by antibiotics only, 6 (75%) recovered quickly but only 3 of them (38%) stayed healthy after 2 months elapsing from the therapy termination. Of the 10 dogs treated by antibiotics combined with immunomodulators, 8 (80%) regained health within a therapeutic period and 7 of them (70%) remained completely cured after 2 months from completion of therapy. The durations of treatment in dogs with the first occurrence of pyoderma and those with recurrent pyoderma were 8.4 and 10.5 weeks, respectively, the difference begin significant. Hair lenght and percentage of the skin area affected had no effect on the therapy duration. The disappearance of pruritus preceded the successful treatment. The results suggest that the joint treatment of deep pyodermas in dogs by antibiotics and immunomodulators may be superior to the purely antibiotic therapy, because of a stronger suppressive effect on the disease relapse.
Cate of OECD: Veterinary science
Year of Publication: 2007
Business Area: other
Detail Business: medicine & science
Country: Czech Republic
Study Area: disease
Name of Journal: ACTA VETERINARIA BRNO
Language: English
Country of Authors: Small Anim Clin, Olomouc 77900, Czech Republic; Vet Res Inst, CS-62132 Brno, Czech Republic; Univ Vet & Pharmaceut Sci, Fac Vet Med, Dept Microbiol & Immunol, Brno, Czech Republic
Press Adress: Sprucek, R (reprint author), Small Anim Clin, Tylova 3, Olomouc 77900, Czech Republic.
Email Address: sprucek@email.cz
Citaion:
Funding:
Lists of Citation: Bousquet E, 1999, VET DERMATOL, V10, P253, DOI 10.1046/j.1365-3164.1999.00184.x; Chabanne Luc, 2000, Methods in Cell Science, V22, P199, DOI 10.1023/A:1009800310840; Craig M, 2003, IN PRACTICE, V25, P418; DeBoer DJ, 2001, VET IMMUNOL IMMUNOP, V81, P239, DOI 10.1016/S0165-2427(01)00345-2; Ehinger AM, 2002, BERL MUNCH TIERARZTL, V115, P57; Foster AP, 2004, VET DERMATOL, V15, P115, DOI 10.1111/j.1365-3164.2004.00363.x; Guaguere E, 1998, PRAT MED CHIR ANIM, V33, P237; LLOYD D, 1996, HLUBOKE PYODERMIE; Mason IS, 1999, VET DERMATOL, V10, P187, DOI 10.1046/j.1365-3164.1999.00183.x; RYBNICEK J, 1999, VYUZITI ANTIMIKROBIA, P25; *SAS I INC, 2005, STAT GRAPH GUID REL; SCOTT DW, 2001, SMALL ANIMAL DERMATO, P230; Winiarczyk S, 1998, MED WETER, V54, P533; Winnicka A, 2000, J VET MED A, V47, P385, DOI 10.1046/j.1439-0442.2000.00298.x
Number of Citaion: 14
Publication: VETERINARNI A FARMACEUTICKA UNIVERZITA BRNO
City of Publication: BRNO
Address of Publication: PALACKEHO 1-3, BRNO CS-612 42, CZECH REPUBLIC
ISSN: 0001-7213
29-Character Source Abbreviation: ACTA VET BRNO
ISO Source Abbreviation: Acta Vet. BRNO
Volume: 76
Version: 3
Start of File: 469
End of File: 474
DOI: 10.2754/avb200776030469
Number of Pages: 6
Web of Science Category: Veterinary Sciences
Subject Category: Veterinary Sciences
Document Delivery Number: 221KN
Unique Article Identifier: WOS:000250226300019
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