학제간연구 | Interdisciplinary Studies in Gambling | 跨学科研究
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- Article] Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid
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DocNo of ILP: 4085
Doc. Type: Article
Title: Exercise and injury increase chondroitin sulfate chain length and decrease hyaluronan chain length in synovial fluid
Authors: Brown, MP; Trumble, TN; Plaas, AHK; Sandy, JD; Romano, M; Hernandez, J; Merritt, KA
Full Name of Authors: Brown, M. P.; Trumble, T. N.; Plaas, A. H. K.; Sandy, J. D.; Romano, M.; Hernandez, J.; Merritt, K. A.
Keywords by Author: chondroitin sulfate; hyaluronan; synovial fluid; cartilage; serum; exercise; osteochondral injury; horse
Keywords Plus: HUMAN ARTICULAR-CARTILAGE; MOLECULAR-WEIGHT; KERATAN SULFATE; JOINT FLUID; GLYCOSAMINOGLYCAN CONCENTRATION; TEMPOROMANDIBULAR JOINTS; SERUM HYALURONAN; OSTEOARTHRITIS; ACID; KNEE
Abstract: Objectives: (1) To investigate the effects of exercise and osteochondral (OC) injury on synovial fluid (SF) chondroitin sulfate (CS) and hyaluronan (HA) concentration and chain length, (2) to compare SF and cartilage CS data from joints with OC fragmentation, and (3) to compare SF CS and HA profiles with those seen in serum from the same horses. Methods: Serum and SF were obtained from (1) normal horses after 8 weeks rest, (2) the same horses after 9 months treadmill training, and (3) horses with OC injury from racing. Articular cartilage was also collected from group 3 horses. Concentrations and chain lengths of CS and HA were determined by gel chromatography and fluorophore-assisted carbohydrate electrophoresis. Results: SF CS peak chain length in the OC injury group increased significantly (18.7 kDa) when compared to rested horses (11.6 kDa), with exercise producing an intermediate chain length (15.6 kDa). Cartilage and serum from the OC injury group had the abnormally long CS chains seen in SF from these horses. Total SF HA was significantly lower in the OC injury group compared to the rested group. Both the OC injury group and the exercised group had significant decreases in SF HA chain length compared to the rested group. Conclusions: Chain length of SF CS was increased by exercise and OC injury. Exercise resulted in a modest increase, whereas OC injury caused a marked increase. In contrast to CS, SF HA chain length was decreased by OC injury, and to a lesser extent by exercise. Chain length analysis of SF CS and HA may provide a useful tool for evaluation of joint health. (c) 2007 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Cate of OECD: Clinical medicine
Year of Publication: 2007
Business Area: other
Detail Business: medicine & science
Country: England
Study Area: globalization, globalization
Name of Journal: OSTEOARTHRITIS AND CARTILAGE
Language: English
Country of Authors: Univ Florida, Coll Vet Med, Dept Large Anim Clin Sci, Gainesville, FL 32610 USA; Univ S Florida, Coll Med, Dept Internal Med, Tampa, FL 33620 USA; Univ S Florida, Coll Med, Dept Mol Pharmacol, Tampa, FL 33620 USA
Press Adress: Brown, MP (reprint author), Univ Florida, Coll Vet Med, Dept Large Anim Clin Sci, Box 100136, Gainesville, FL 32610 USA.
Email Address: brownmu@mail.vetmed.ufl.edu
Citaion:
Funding:
Lists of Citation: BALAZS EA, 1967, ARTHRITIS RHEUM, V10, P357, DOI 10.1002/art.1780100407; Bayliss MT, 1999, J BIOL CHEM, V274, P15892, DOI 10.1074/jbc.274.22.15892; Belcher C, 1997, ANN RHEUM DIS, V56, P299, DOI 10.1136/ard.56.5.299; BROWN MP, 2003, ORTHOPAEDIC RES SOC, V28, P709; Brown MP, 1998, AM J VET RES, V59, P786; BROWN MP, 2006, OSTEOARTHRITIS CA SB, V14, pS64, DOI 10.1016/S1063-4584(07)60550-0; BROWN MP, 2001, 47 ANN M ORTH RES SO, DOI UNSP 0368; Budsberg SC, 2006, AM J VET RES, V67, P429, DOI 10.2460/ajvr.67.3.429; Burton-Wurster N, 1993, JOINT CARTILAGE DEGR, P347; Calabro A, 2001, OSTEOARTHR CARTILAGE, V9, pS16, DOI 10.1053/joca.2001.0439; Canapp SO, 2005, VET COMP ORTHOPAED, V18, P169; CARNEY SL, 1985, J ORTHOPAED RES, V3, P140, DOI 10.1002/jor.1100030203; COGBURN JN, 1986, CARBOHYD RES, V151, P207, DOI 10.1016/S0008-6215(00)90341-0; DAHL LB, 1985, ANN RHEUM DIS, V44, P817, DOI 10.1136/ard.44.12.817; DEUTSCH AJ, 1995, J ORTHOPAED RES, V13, P230, DOI 10.1002/jor.1100130211; Elliott AL, 2005, ARTHRITIS RHEUM, V52, P105, DOI 10.1002/art.20724; Frisbie DD, 2006, VET COMP ORTHOPAED, V19, P142; Fuller CJ, 2001, OSTEOARTHR CARTILAGE, V9, P49, DOI 10.1053/joca.2000.0349; GAFFEN JD, 1994, ANAL BIOCHEM, V218, P124, DOI 10.1006/abio.1994.1150; HAUBECK HD, 1995, ARTHRITIS RHEUM, V38, P669, DOI 10.1002/art.1780380515; HILBERT BJ, 1984, AUST VET J, V61, P22, DOI 10.1111/j.1751-0813.1984.tb07125.x; HOLMES MWA, 1988, BIOCHEM J, V250, P435; IMANARI T, 1992, J CHROMATOGR-BIOMED, V574, P142, DOI 10.1016/0378-4347(92)80109-4; Ishimaru JI, 2001, OSTEOARTHR CARTILAGE, V9, P365, DOI 10.1053/joca.2000.0397; Itano N, 1999, J BIOL CHEM, V274, P25085, DOI 10.1074/jbc.274.35.25085; LEMAIRE M, 1987, BIOCHEM J, V243, P399; Li M, 1997, ARCH BIOCHEM BIOPHYS, V341, P245, DOI 10.1006/abbi.1997.9970; LINDQVIST U, 1988, SCAND J CLIN LAB INV, V48, P765, DOI 10.3109/00365518809088758; LOHMANDER LS, 1995, BRIT J RHEUMATOL, V34, P599; LOHMANDER LS, 1989, ARTHRITIS RHEUM, V32, P1434, DOI 10.1002/anr.1780321113; MCNEIL JD, 1985, ANN RHEUM DIS, V44, P780, DOI 10.1136/ard.44.11.780; Miyaguchi M, 2003, OSTEOARTHR CARTILAGE, V11, P252, DOI 10.1016/S1063-4584(02)00372-2; MORRIS EA, 1990, AM J VET RES, V51, P59; Murakami KI, 1998, J ORAL MAXIL SURG, V56, P199, DOI 10.1016/S0278-2391(98)90869-2; Oguchi T, 2004, CONNECT TISSUE RES, V45, P197, DOI 10.1080/03008200490523031; Okazaki J, 1997, EUR J ORAL SCI, V105, P440; Praest BM, 1997, CLIN CHIM ACTA, V266, P117, DOI 10.1016/S0009-8981(97)00122-8; Price FM, 1996, J PHYSIOL-LONDON, V495, P821; Price FM, 1996, J PHYSIOL-LONDON, V495, P803; Recklies AD, 2001, BIOCHEM J, V354, P17, DOI 10.1042/0264-6021:3540017; RODEN L, 1972, METHOD ENZYMOL, V8, P638; RODEN L, 1980, BIOCH GLYCOPROTEINS, P286; SAARI H, 1991, ANN MED, V23, P29, DOI 10.3109/07853899109147927; Sharif M, 1996, BRIT J RHEUMATOL, V35, P951; Shibata T, 1998, J ORAL MAXIL SURG, V56, P209, DOI 10.1016/S0278-2391(98)90871-0; SHINMEI M, 1992, ARTHRITIS RHEUM, V35, P1304; Takahashi T, 2004, J ORAL PATHOL MED, V33, P224, DOI 10.1111/j.0904-2512.2004.00024.x; Theoret CL, 1996, VET SURG, V25, P142, DOI 10.1111/j.1532-950X.1996.tb01390.x; Tulamo RM, 1996, AM J VET RES, V57, P932; TURAN Y, 2007, CLIN RHEUMATOL; Uesaka Shinji, 2001, Journal of Nippon Medical School, V68, P165, DOI 10.1272/jnms.68.165; Yamada H, 1999, J Orthop Sci, V4, P250, DOI 10.1007/s007760050100; Yoshihara Y, 1996, Ryumachi, V36, P734
Number of Citaion: 53
Publication: W B SAUNDERS CO LTD
City of Publication: LONDON
Address of Publication: 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
ISSN: 1063-4584
29-Character Source Abbreviation: OSTEOARTHR CARTILAGE
ISO Source Abbreviation: Osteoarthritis Cartilage
Volume: 15
Version: 11
Start of File: 1318
End of File: 1325
DOI: 10.1016/j.joca.2007.04.005
Number of Pages: 8
Web of Science Category: Orthopedics; Rheumatology
Subject Category: Orthopedics; Rheumatology
Document Delivery Number: 235CS
Unique Article Identifier: WOS:000251211700013
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