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- Article; Proceedings Paper] Morphologic changes associated with functional adaptation of the navicular bone of horses
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DocNo of ILP: 4073
Doc. Type: Article; Proceedings Paper
Title: Morphologic changes associated with functional adaptation of the navicular bone of horses
Authors: Bentley, VA; Sample, SJ; Livesey, MA; Scollay, MC; Radtke, CL; Frank, JD; Kalscheur, VL; Muir, P
Full Name of Authors: Bentley, V. A.; Sample, S. J.; Livesey, M. A.; Scollay, M. C.; Radtke, C. L.; Frank, J. D.; Kalscheur, V. L.; Muir, P.
Keywords by Author: functional adaptation; microdamage; osteocytes; targeted remodeling
Keywords Plus: CORTICAL BONE; IN-VIVO; FATIGUE; MICRODAMAGE; DISEASE; AGE; MICROCRACKING; ACCUMULATION; RACEHORSES; FRACTURES
Abstract: Failure of functional adaptation to protect the skeleton from damage is common and is often associated with targeted remodeling of bone microdamage. Horses provide a suitable model for studying loading-related skeletal disease because horses are physically active, their exercise is usually regulated, and adaptive failure of various skeletal sites is common. We performed a histologic study of the navicular bone of three groups of horses: (1) young racing Thoroughbreds (n = 10); (2) young unshod ponies (n = 10); and (3) older horses with navicular syndrome (n = 6). Navicular syndrome is a painful condition that is a common cause of lameness and is associated with extensive remodeling of the navicular bone; a sesamoid bone located within the hoof which articulates with the second and third phalanges dorsally. The following variables were quantified: volumetric bone mineral density; cortical thickness (Ct.Th); bone volume fraction, microcrack surface density; density of osteocytes and empty lacunae; and resorption space density. Birefringence of bone collagen was also determined using circularly polarized light microscopy and disruption of the lacunocanalicular network was examined using confocal microscopy. Remodeling of the navicular bone resulted in formation of transverse secondary osteons orientated in a lateral to medial direction; bone collagen was similarly orientated. In horses with navicular syndrome, remodeling often led to the formation of intracortical cysts and development of multiple tidemarks at the articular surface. These changes were associated with high microcrack surface density, low bone volume fraction, low density of osteocytes, and poor osteocyte connectivity. Empty lacunae were increased in Thoroughbreds. Resorption space density was not increased in horses with navicular syndrome. Taken together, these data suggest that the navicular bone may experience habitual bending across the sagittal plane. Consequences of cumulative cyclic loading in horses with navicular syndrome include arthritic degeneration of adjacent joints and adaptive failure of the navicular bone, with accumulation of microdamage and associated low bone mass, poor osteocyte connectivity, and low osteocyte density, but not formation of greater numbers of resorption spaces.
Cate of OECD: Basic medicine
Year of Publication: 2007
Business Area: horse race
Detail Business: racehorse
Country: England
Study Area: modeling, modeling, network & communication, network, older, habit, syndrome
Name of Journal: JOURNAL OF ANATOMY
Language: English
Country of Authors: Univ Wisconsin, Sch Vet Med, Comparat Orthopaed Res Lab, Madison, WI 53706 USA
Press Adress: Muir, P (reprint author), Univ Wisconsin, Sch Vet Med, Comparat Orthopaed Res Lab, 2015 Linden Dr, Madison, WI 53706 USA.
Email Address: muirp@svm.vetmed.wisc.edu
Citaion:
Funding:
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Number of Citaion: 30
Publication: BLACKWELL PUBLISHING
City of Publication: OXFORD
Address of Publication: 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
ISSN: 0021-8782
29-Character Source Abbreviation: J ANAT
ISO Source Abbreviation: J. Anat.
Volume: 211
Version: 5
Start of File: 662
End of File: 672
DOI: 10.1111/j.1469-7580.2007.00800.x
Number of Pages: 11
Web of Science Category: Anatomy & Morphology
Subject Category: Anatomy & Morphology
Document Delivery Number: 222AA
Unique Article Identifier: WOS:000250267300010
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