학제간연구 | Interdisciplinary Studies in Gambling | 跨学科研究
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- Article] Electrocautery versus 23% NaOH infiltration to induce subglottic stenosis in a canine experimental model
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DocNo of ILP: 4055
Doc. Type: Article
Title: Electrocautery versus 23% NaOH infiltration to induce subglottic stenosis in a canine experimental model
Authors: Hanauer, AD; Fraga, JC; Sousa, JK; Sanches, PR; Duarte, ME; Ulbrich-Kulczynski, J; Filho, OH; Saueressig, MG
Full Name of Authors: Hanauer, Aline D.; Fraga, Jose Carlos; Sousa, Joao K.; Sanches, Paulo R.; Duarte, Marcos E.; Ulbrich-Kulczynski, Jane; Filho, Orlando H.; Saueressig, Mauricio G.
Keywords by Author: experimental subglottic stenosis; eletrocoagulation; sodium hydroxide
Keywords Plus: LARYNGOTRACHEAL RECONSTRUCTION; PORCINE MODEL; EXPERIENCE; CHILDREN; TRACHEOTOMY; MANAGEMENT; RESECTION; INFANTS; UPDATE
Abstract: Subglottic stenosis (SGS) is defined as the narrowing of the lower larynx. Difficulties in the management of subglottic stenosis, especially in the pediatric population, justify the development of experimental models. The objective of this study was to compare the two methods of experimental subglottic stenosis induction. Twenty-three dogs were randomly selected and assigned by lottery to either one of the two groups: Gp I (n = 10) of electrocoagulation; and Gp II (n = 13) of 23% NaOH injection. In Gp I, self-interruption electrocoagulation was applied to one point in each of the four quadrants of the cricoid cartilage. In Gp II, 0.2 ml of 23% NaOH was injected in the submucosal layer in the anterior and posterior portions of the cricoid cartilage. Once a week, endoscopy was performed and the caliber of the subglottic region was measured using endotracheal tubes, and the injection was repeated if there were no signs of subglottic stenosis. The animals were killed on day 21; animals that developed respiratory distress were killed before day 21. One animal in Gp I died on day14 after the injection and during transportation; two animals in Gp II died, one on day 7 due to a tracheoesophageal fistula, and the other of unknown causes on day 5. Significant subglottic stenosis (over 51% obstruction) was found in 67% of the animals in Gp I and in 64% of those in Gp II (P = 0.99). Median time to development of significant stenosis was 21 days in both groups, and required either two or three injections. Mean time for the performance of the procedures was significantly shorter (P < 0.01) in Gp I ( mean: 6.36 min) than in Gp II (mean: 14.88 min). Electrocoagulation and 23% NaOH injection in the subglottic region were effective in the development of significant subglottic stenosis in dogs, both methods leading to stenosis in the same period of time and after the same number of procedures. However, electrocoagulation was the fastest method.
Cate of OECD: Clinical medicine
Year of Publication: 2007
Business Area: lottery
Detail Business: lottery
Country: USA
Study Area:
Name of Journal: PEDIATRIC SURGERY INTERNATIONAL
Language: English
Country of Authors: [Hanauer, Aline D.; Fraga, Jose Carlos; Sousa, Joao K.; Sanches, Paulo R.; Duarte, Marcos E.; Ulbrich-Kulczynski, Jane; Filho, Orlando H.; Saueressig, Mauricio G.] Univ Fed Rio Grande do Sul, Sch Med, Hosp Clin, BR-90000000 Porto Alegre, RS, Brazil
Press Adress: Fraga, JC (reprint author), Univ Fed Rio Grande do Sul, Sch Med, Hosp Clin, Rue Ramiro Barcelos 2500,Sala 600, BR-90000000 Porto Alegre, RS, Brazil.
Email Address: jc.fraga@terra.com.br
Citaion:
Funding:
Lists of Citation: CASSOL VE, 2001, J PNEUMOL, V27, P143; Cotton RT, 2000, OTOLARYNG CLIN N AM, V33, P111, DOI 10.1016/S0030-6665(05)70210-3; COTTON RT, 1981, ANN OTO RHINOL LARYN, V90, P516; COTTON RT, 1980, ANN OTO RHINOL LARYN, V89, P508; COTTON RT, 1989, LARYNGOSCOPE, V99, P1111; Eliashar R, 2000, OTOLARYNG HEAD NECK, V122, P84, DOI 10.1016/S0194-5998(00)70149-5; FINNEGAN DA, 1975, ANN OTOL, V81, P643; FRAGA JCS, 1994, REV BRAS OTORRINOLAR, V60, P35; Goldim JR, 1995, PESQUISA SAUDE DIREI; HOLINGER LD, 1982, ANN OTO RHINOL LARYN, V91, P407; HOLINGER PH, 1976, ANN OTO RHINOL LARYN, V85, P591; Jewett BS, 2000, OTOLARYNG HEAD NECK, V122, P488, DOI 10.1016/S0194-5998(00)70089-1; MARQUETTE CH, 1995, ANN THORAC SURG, V60, P651; MARSHAK G, 1982, LARYNGOSCOPE, V92, P805, DOI 10.1288/00005537-198207000-00018; MARTINS RHG, 1995, REV BRAS OTORRINOLAR, V44, P181; MCCLAY JE, 2004, SUBGLOTTIC STENOSIS; Midwinter KI, 2002, J LARYNGOL OTOL, V116, P532; Mitskavich MT, 1996, LARYNGOSCOPE, V106, P301, DOI 10.1097/00005537-199603000-00011; Mitskavich MT, 1997, AM J OTOLARYNG, V18, P315, DOI 10.1016/S0196-0709(97)90025-9; Monnier P, 1998, ANN OTO RHINOL LARYN, V107, P961; MYER CM, 1994, ANN OTO RHINOL LARYN, V103, P319; RANNE RD, 1991, J PEDIATR SURG, V26, P255, DOI 10.1016/0022-3468(91)90498-I; Rutter MJ, 2003, PEDIAT OTOLARYNGOLOG, P1519; Verkindre C, 1999, EUR RESPIR J, V14, P796, DOI 10.1034/j.1399-3003.1999.14d12.x; WEBER TR, 1991, J THORAC CARDIOV SUR, V102, P29
Number of Citaion: 25
Publication: SPRINGER
City of Publication: NEW YORK
Address of Publication: 233 SPRING STREET, NEW YORK, NY 10013 USA
ISSN: 0179-0358
29-Character Source Abbreviation: PEDIATR SURG INT
ISO Source Abbreviation: Pediatr. Surg. Int.
Volume: 23
Version: 12
Start of File: 1227
End of File: 1231
DOI: 10.1007/s00383-007-2017-4
Number of Pages: 5
Web of Science Category: Pediatrics; Surgery
Subject Category: Pediatrics; Surgery
Document Delivery Number: 248MT
Unique Article Identifier: WOS:000252158100016
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