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- Article] Synthesis and biological evaluation of isoflavone analogues from Dalbergia oliveri
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DocNo of ILP: 4033
Doc. Type: Article
Title: Synthesis and biological evaluation of isoflavone analogues from Dalbergia oliveri
Authors: Deesamer, S; Kokpol, U; Chavasiri, W; Douillard, S; Peyrot, V; Vidal, N; Combes, S; Finet, JP
Full Name of Authors: Deesamer, Sujittra; Kokpol, Udom; Chavasiri, Warinthorn; Douillard, Soazig; Peyrot, Vincent; Vidal, Nicolas; Combes, Sebastien; Finet, Jean-Pierre
Keywords by Author:
Keywords Plus: ORGANOLEAD-MEDIATED ARYLATION; SELECTIVE SYNTHESIS; TUBULIN; CHALCONES; DERIVATIVES; PROTEIN; BRAIN
Abstract: Mucronulatol 1 and violanone 2 isolated from Dalbergia oliveri Gamble, and the corresponding isoflavone 3 were prepared by ligand coupling reactions involving organolead reagent. Biological studies have shown a significant cytotoxic effect against an HBL100 leukemia cell line only for isoflavan 1 with an IC50 value amounting to 5.7 mu M. All the drugs modestly inhibit the in vitro microtubule assembly, independently of the cytotoxic ability. Natural compounds 1 and 2 have no antibacterial activity, but are potent inhibitors of the Fusarium oxysporum phytopathogenic fungal growth. (c) 2007 Elsevier Ltd. All rights reserved.
Cate of OECD: Chemical sciences
Year of Publication: 2007
Business Area: other
Detail Business: medicine & science
Country: England
Study Area: Evaluation, choice, drug
Name of Journal: TETRAHEDRON
Language: English
Country of Authors: [Vidal, Nicolas; Combes, Sebastien; Finet, Jean-Pierre] CNRS, UMR 6517, Case 521, F-13397 Marseille 20, France; [Vidal, Nicolas; Combes, Sebastien; Finet, Jean-Pierre] Aix Marseille Univ, Fac Sci & Tech St Jerome, F-13397 Marseille, France; [Deesamer, Sujittra; Kokpol, Udom; Chavasiri, Warinthorn] Chulalongkorn Univ, Fac Sci, Nat Prod Res Unit, Bangkok 10330, Thailand; [Douillard, Soazig; Peyrot, Vincent] CNRS, FRE 2737, F-13385 Marseille, France; [Douillard, Soazig; Peyrot, Vincent] Aix Marseille Univ, Fac Pharm, F-13385 Marseille 5, France
Press Adress: Combes, S (reprint author), CNRS, UMR 6517, Case 521, F-13397 Marseille 20, France.
Email Address: sebastien.combes@up.univ-mrs.fr
Citaion:
Funding:
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Number of Citaion: 35
Publication: PERGAMON-ELSEVIER SCIENCE LTD
City of Publication: OXFORD
Address of Publication: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
ISSN: 0040-4020
29-Character Source Abbreviation: TETRAHEDRON
ISO Source Abbreviation: Tetrahedron
Volume: 63
Version: 52
Start of File: 12986
End of File: 12993
DOI: 10.1016/j.tet.2007.10.030
Number of Pages: 8
Web of Science Category: Chemistry, Organic
Subject Category: Chemistry
Document Delivery Number: 249NQ
Unique Article Identifier: WOS:000252235900022
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