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- Article] Scale-up of High-Shear Mixer Granulators
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DocNo of ILP: 3981
Doc. Type: Article
Title: Scale-up of High-Shear Mixer Granulators
Authors: Rahmanian, N; Ng, BH; Hassanpour, A; Ding, YL; Antony, SJ; Jia, XD; Ghadiri, M; van der Wel, PGJ; Krug-Polman, A; York, D; Bayly, A; Tan, HS
Full Name of Authors: Rahmanian, N.; Ng, B. H.; Hassanpour, A.; Ding, Y. L.; Antony, S. J.; Jia, X. D.; Ghadiri, M.; van der Wel, P. G. J.; Krug-Polman, A.; York, D.; Bayly, A.; Tan, H. S.
Keywords by Author: granulation; high-shear granulator; scale-up; strength; Cyclomix; DEM modelling; PEPT
Keywords Plus: EMISSION PARTICLE TRACKING; BINDER VISCOSITY; IMPACT BREAKAGE; AGGLOMERATION; PARAMETERS; GRANULES; STRENGTH; BEHAVIOR; GROWTH; MOTION
Abstract: The mechanics of particle interactions and the prevailing level of compressive stresses and shear strains are affected by the scale of operation, which in turn affects the granule structure, strength and functional properties. This may be the main reason why the current scaling relationships are ineffective from a viewpoint of product engineering. In a research programme supported by the EPSRC and four industrial organizations, i.e. Borax Europe, Hosokawa Micron BV, Pfizer Global Research and Development, and Procter and Gamble, we have addressed the following topics: Development of methodologies for quantifying the structure of granules in terms of internal voidage and composition distributions, strength, shape, size and density. Identification of the parameters that affect the structure of granules by using fundamental theories of microscopic contact mechanics of particles using DEM, macroscopic granular flow dynamics and kinetics of wetting. Experimental work across several length scales (1 L, 5 L, 50 L and 250 L) to aid the analysis of the process. In this paper, an overview of findings and their implications for granulation practice is presented.
Cate of OECD: Chemical engineering
Year of Publication: 2008
Business Area: other
Detail Business: medicine & science
Country: Japan
Study Area: globalization, globalization, behavior
Name of Journal: KONA POWDER AND PARTICLE JOURNAL
Language: English
Country of Authors: [Rahmanian, N.; Ng, B. H.; Hassanpour, A.; Ding, Y. L.; Antony, S. J.; Jia, X. D.; Ghadiri, M.] Univ Leeds, Inst Particle Sci & Engn, Leeds LS2 9JT, W Yorkshire, England; [York, D.; Bayly, A.; Tan, H. S.] Procter & Gamble, Cincinnati, OH USA
Press Adress: Ghadiri, M (reprint author), Univ Leeds, Inst Particle Sci & Engn, Leeds LS2 9JT, W Yorkshire, England.
Email Address: m.ghadiri@leeds.ac.uk
Citaion:
Funding: EPSRC [GR/S25029/01]; Borax Europe Ltd.; Hosokawa Micron B.V.; Pfizer Global RD; PG
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Number of Citaion: 41
Publication: HOSOKAWA POWDER TECHNOL FOUNDATION
City of Publication: HIRAKATA-SHI
Address of Publication: NO 9, 1-CHOME, SHOUDAI TAJIKA, HIRAKATA-SHI, OSAKA 573-1132, JAPAN
ISSN: 0288-4534
29-Character Source Abbreviation: KONA POWDER PART J
ISO Source Abbreviation: KONA Powder Part. J.
Volume: 26
Version:
Start of File: 190
End of File: 204
DOI:
Number of Pages: 15
Web of Science Category: Engineering, Chemical; Materials Science, Multidisciplinary
Subject Category: Engineering; Materials Science
Document Delivery Number: 440GC
Unique Article Identifier: WOS:000265687800015
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