학제간연구 | Interdisciplinary Studies in Gambling | 跨学科研究
- date : 2015-05-20 01:10|hit : 1507
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- Article] Preserved orbitofrontal function in first-episode schizophrenia - Further evidence from the object alternation paradigm
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DocNo of ILP: 3976
Doc. Type: Article
Title: Preserved orbitofrontal function in first-episode schizophrenia - Further evidence from the object alternation paradigm
Authors: Gonzalez-Blanch, C; Vazquez-Barquero, JL; Carral-Fernandez, L; Rodriguez-Sanchez, JM; Alvarez-Jimenez, M; Crespo-Facorro, B
Full Name of Authors: Gonzalez-Blanch, Cesar; Vazquez-Barquero, Jose Luis; Carral-Fernandez, Laura; Rodriguez-Sanchez, Jose Manuel; Alvarez-Jimenez, Mario; Crespo-Facorro, Benedicto
Keywords by Author: object alternation; decision making; orbitofrontal; schizophrenia; first episode
Keywords Plus: OLFACTORY IDENTIFICATION DEFICITS; OBSESSIVE-COMPULSIVE DISORDER; IOWA GAMBLING TASK; DECISION-MAKING; DOUBLE DISSOCIATION; DYSFUNCTION; PSYCHOSIS; IMPAIRMENT; SYMPTOMS; ABILITY
Abstract: Neuropsychological literature indicates that performance on Object Alternation Task (OAT) can be linked to the orbitofrontal cortex (OFC). Patients with chronic schizophrenia perform poorly on behavioral and neuropsychological tasks related to OFC functions. In a previous study using the Iowa Gambling Task, we found unimpaired performance in a sample of individuals with first-episode schizophrenia (FES) spectrum disorders. In this study, we aimed to extend our study of OFC functions by using the OAT paradigm, to determine whether there are abnormalities in the early phases of schizophrenia. We examined the performance of 70 patients with FES and 21 healthy controls on a computerized version of OAT. There were no significant differences between patients and control subjects with respect to the OAT. This finding suggests that the OFC function, as measured by decision-making tasks, is preserved in the early phases of schizophrenia.
Cate of OECD: Clinical medicine
Year of Publication: 2008
Business Area: gamble
Detail Business: gamble
Country: USA
Study Area:
Name of Journal: JOURNAL OF NERVOUS AND MENTAL DISEASE
Language: English
Country of Authors: [Gonzalez-Blanch, Cesar; Vazquez-Barquero, Jose Luis; Carral-Fernandez, Laura; Rodriguez-Sanchez, Jose Manuel; Alvarez-Jimenez, Mario; Crespo-Facorro, Benedicto] Hosp Univ Marques Valdecilla, Unidad Invest Psiquiatria Cantabria, Dept Psychiat, Sch Med,Psyschiat Res Unit Cantabria, Santander 39008, Spain; [Alvarez-Jimenez, Mario] ORYGEN Res Ctr, Melbourne, Vic, Australia
Press Adress: Gonzalez-Blanch, C (reprint author), Hosp Univ Marques Valdecilla, Unidad Invest Psiquiatria Cantabria, Dept Psychiat, Sch Med,Psyschiat Res Unit Cantabria, Planta 2A,Edif 2 Noviembre,Avda Valdecilla S-N, Santander 39008, Spain.
Email Address: cgblanch@terra.es
Citaion: Alvarez-Jimenez, Mario/0000-0002-3535-9086
Funding:
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Number of Citaion: 29
Publication: LIPPINCOTT WILLIAMS & WILKINS
City of Publication: PHILADELPHIA
Address of Publication: 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
ISSN: 0022-3018
29-Character Source Abbreviation: J NERV MENT DIS
ISO Source Abbreviation: J. Nerv. Ment. Dis.
Volume: 196
Version: 1
Start of File: 67
End of File: 70
DOI: 10.1097/NMD.0b013e31815fa4c1
Number of Pages: 4
Web of Science Category: Clinical Neurology; Psychiatry
Subject Category: Neurosciences & Neurology; Psychiatry
Document Delivery Number: 253IN
Unique Article Identifier: WOS:000252512000010
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