학제간연구 | Interdisciplinary Studies in Gambling | 跨学科研究
- date : 2015-05-20 01:10|hit : 1385
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- Article] Balancing science and community concerns in resource-limited settings: Project Accept in rural Zimbabwe
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DocNo of ILP: 3950
Doc. Type: Article
Title: Balancing science and community concerns in resource-limited settings: Project Accept in rural Zimbabwe
Authors: Chingono, A; Lane, T; Chitumba, A; Kulich, M; Morin, S
Full Name of Authors: Chingono, Alfred; Lane, Tim; Chitumba, Alexander; Kulich, Michal; Morin, Stephen
Keywords by Author:
Keywords Plus: HIV PREVENTION RESEARCH; CLINICAL-TRIALS; CONSULTATION; WILLINGNESS; PARTICIPATE; AIDS
Abstract: Background The methods and purposes of randomization are often poorly understood by participants in clinical trials. Individual misunderstandings can be compounded in community-based intervention trials, especially in research-naive communities. Randomizing entire communities to intervention or control status risks creating the perception that control communities are being denied desirable services, ultimately undermining trust in the research process. Purpose To develop a randomization scheme for an HIV prevention trial of a community-level intervention that would be credible to the communities involved while maintaining the scientific integrity of the intervention trial at a rural site in Zimbabwe. Methods Project staff developed strong partnerships with community stakeholders and embedded randomization into the trial's community preparedness processes. Local idioms were used to explain the concept, purpose, and mechanics of randomization. Actual allocation of communities to intervention or control status took place at a public lottery conducted by local chiefs. Results The Project obtained the endorsement of its randomization of eight rural communities by local political stakeholders and community members. Limitations This case study may not generalize to other settings. Conclusions By developing strong community partnerships, and communicating randomization through local idioms, community based intervention trials conducted in resource-poor environments can successfully mitigate risks inherent in randomizing communities to control status.
Cate of OECD: Basic medicine
Year of Publication: 2008
Business Area: lottery
Detail Business: lottery
Country: England
Study Area: regulation, control, clinical trial, clinical trial, older, risk, AIDS
Name of Journal: CLINICAL TRIALS
Language: English
Country of Authors: [Lane, Tim; Morin, Stephen] Univ Calif San Francisco, Ctr AIDS Prevent Studies, San Francisco, CA 94143 USA; [Chingono, Alfred; Chitumba, Alexander] Univ Zimbabwe, Dept Psychiat, Harare, Zimbabwe; [Kulich, Michal] Charles Univ Prague, Fac Math & Phys, Prague, Czech Republic
Press Adress: Lane, T (reprint author), Univ Calif San Francisco, Ctr AIDS Prevent Studies, San Francisco, CA 94143 USA.
Email Address: tim.lane@ucsf.edu
Citaion: Kulich, Michal/0000-0002-2812-8968
Funding:
Lists of Citation: *COUNC INT ORG MED, 2002, CIOMS GUID; Ellis PM, 2001, J CLIN ONCOL, V19, P3554; Featherstone K, 1998, BRIT MED J, V317, P1177; Joffe S, 2001, J NATL CANCER I, V93, P139, DOI 10.1093/jnci/93.2.139; Kerr C, 2004, J MED ETHICS, V30, P80, DOI 10.1136/jme.2002.001123; Lo B, 2003, BRIT MED J, V327, P337, DOI 10.1136/bmj.327.7410.337; McGrath JW, 2001, J ACQ IMMUN DEF SYND, V27, P381; MELTON GB, 1988, AM PSYCHOL, V43, P573, DOI 10.1037/0003-066X.43.7.573; Morin SF, 2003, JAIDS-J ACQ IMM DEF, V33, P513; Moulton LH, 2007, CLIN TRIALS, V4, P190, DOI 10.1177/1740774507076937; Page-Shafer K, 2005, LANCET, V366, P1499, DOI 10.1016/S0140-6736(05)67146-2; Pucci E, 1999, BRIT MED J, V318, P875; Stead M, 2005, J MED ETHICS, V31, P664, DOI 10.1135/jme.2004.011064; Coates TJ, 2000, LANCET, V356, P103
Number of Citaion: 14
Publication: SAGE PUBLICATIONS LTD
City of Publication: LONDON
Address of Publication: 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
ISSN: 1740-7745
29-Character Source Abbreviation: CLIN TRIALS
ISO Source Abbreviation: Clin. Trials
Volume: 5
Version: 3
Start of File: 273
End of File: 276
DOI: 10.1177/1740774508091576
Number of Pages: 4
Web of Science Category: Medicine, Research & Experimental
Subject Category: Research & Experimental Medicine
Document Delivery Number: 331TM
Unique Article Identifier: WOS:000258035500011
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