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- Article] Association of polymorphisms of dopamine D-2 receptor (DRD2), and dopamine transporter (DAT(1)) genes with schizoid/avoidant behaviors (SAB)
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DocNo of ILP: 7470
Doc. Type: Article
Title: Association of polymorphisms of dopamine D-2 receptor (DRD2), and dopamine transporter (DAT(1)) genes with schizoid/avoidant behaviors (SAB)
Authors: Blum, K; Braverman, ER; Wu, S; Cull, JG; Chen, TJH; Gill, J; Wood, R; Eisenberg, A; Sherman, M; Davis, KR; Matthews, D; Fischer, L; Schnautz, N; Walsh, W; Pontius, AA; Zedar, M; Kaats, G; Comings, DE
Full Name of Authors: Blum, K; Braverman, ER; Wu, S; Cull, JG; Chen, TJH; Gill, J; Wood, R; Eisenberg, A; Sherman, M; Davis, KR; Matthews, D; Fischer, L; Schnautz, N; Walsh, W; Pontius, AA; Zedar, M; Kaats, G; Comings, DE
Keywords by Author: schizoid/avoidant behavior; polymorphisms; dopamine D-2 receptor gene (DRD2); dopamine transporter gene (DAT(1))
Keywords Plus: PROLONGED P300 LATENCY; PERSONALITY-DISORDERS; BETA-HYDROXYLASE; D2 RECEPTOR; ALLELIC ASSOCIATION; SUBSTANCE-ABUSE; ALCOHOLISM; LINKAGE; LOCUS; VULNERABILITY
Abstract: The dopaminergic system, and in particular the dopamine D-2 receptor, has been implicated in reward mechanisms in the brain. Dysfunction of the D-2 dopamine receptors leads to aberrant substance-seeking behaviors (ethanol, drugs, tobacco, and food) and other related behaviors (pathological gambling, Tourette's disorder, attention-deficit/hyperactivity disorder). This is the first study supporting a strong association between the dopamine D-2 receptor Tag A(1) allele with schizoid/avoidant behavior (SAB). Additionally, an albeit weaker association between the 480-bp VNTR 10/10 allele of the dopamine transporter (DAT(1)) gene with SAB was similarly found.
Cate of OECD: Biological sciences
Year of Publication: 1997
Business Area: gamble
Detail Business: gamble
Country: England
Study Area: culture, tour, personal, dopamine, drug
Name of Journal: MOLECULAR PSYCHIATRY
Language: English
Country of Authors: NYU,SCH MED,DEPT PSYCHIAT,NEW YORK,NY 10010; CITY HOPE NATL MED CTR,DEPT MED GENET,DUARTE,CA 91010; KANTROLL INC,SAN ANTONIO,TX 78209; CHANG JUNG UNIV,TAINAN,TAIWAN; UTHSC,DEPT COMP RESOURCES,SAN ANTONIO,TX; UNIV N TEXAS,CTR HLTH SCI,DEPT PATHOL,DNA IDENT LAB,FT WORTH,TX 76107; COMPREHENS NEUROBEHAV SYST,AUSTIN,TX 78246; SAN MARCOS TREATMENT CTR,SAN MARCOS,TX 78667; HLTH RES INST,PFEIFFER TREATMENT CTR,NAPERVILLE,IL 60563; HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02114; HLTH & MED RES FDN,SAN ANTONIO,TX 78209
Press Adress: Blum, K (reprint author), UNIV TEXAS,HLTH SCI CTR,SCH PUBL HLTH HOUSTON,DEPT BEHAV SCI,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284, USA.
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Number of Citaion: 79
Publication: STOCKTON PRESS
City of Publication: BASINGSTOKE
Address of Publication: HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS
ISSN: 1359-4184
29-Character Source Abbreviation: MOL PSYCHIATR
ISO Source Abbreviation: Mol. Psychiatr.
Volume: 2
Version: 3
Start of File: 239
End of File: 246
DOI: 10.1038/sj.mp.4000261
Number of Pages: 8
Web of Science Category: Biochemistry & Molecular Biology; Neurosciences; Psychiatry
Subject Category: Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
Document Delivery Number: WY048
Unique Article Identifier: WOS:A1997WY04800013
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