선호·결정 | Cases and Studies of Preference and Decision-Making in Lottery & Gambling | 偏好 & 决定
- date : 2015-05-20 01:10|hit : 2032
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- Article] Decision-making impairments in the context of intact reward sensitivity in schizophrenia
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DocNo of ILP: 3722
Doc. Type: Article
Title: Decision-making impairments in the context of intact reward sensitivity in schizophrenia
Authors: Heerey, EA; Bell-Warren, KR; Gold, JM
Full Name of Authors: Heerey, Erin A.; Bell-Warren, Kimberly R.; Gold, James M.
Keywords by Author: decision-making; learning; reward sensitivity; schizophrenia
Keywords Plus: IOWA GAMBLING TASK; GENDER-DIFFERENCES; PREFRONTAL CORTEX; PARIETAL CORTEX; MENTAL-ILLNESS; TIME-COURSE; EMOTION; EXPERIENCE; DYSFUNCTION; COGNITION
Abstract: Background: Deficits in motivated behavior and decision-making figure prominently in the behavioral syndrome that characterizes schizophrenia and are difficult both to treat and to understand. One explanation for these deficits is that schizophrenia decreases sensitivity to rewards in the environment. An alternate explanation is that sensitivity to rewards is intact but that poor integration of affective with cognitive information impairs the ability to use this information to guide behavior. Methods: We tested reward sensitivity with a modified version of an existing signal detection task with asymmetric reinforcement and decision-making with a probabilistic decision-making task in 40 participants with schizophrenia and 26 healthy participants. Results: Results showed normal sensitivity to reward in participants with schizophrenia but differences in choice patterns on the decision making task. A logistic regression model of the decision-making data showed that participants with schizophrenia differed from healthy participants in the ability to weigh potential outcomes, specifically potential losses, when choosing between competing response options. Deficits in working memory ability accounted for group differences in ability to use potential outcomes during decision-making. Conclusions: These results suggest that the implicit mechanisms that drive reward-based learning are surprisingly intact in schizophrenia but that poor ability to integrate cognitive and affective information when calculating the value of possible choices might hamper the ability to use such information during explicit decision-making.
Cate of OECD: Basic medicine
Year of Publication: 2008
Business Area: gamble
Detail Business: gamble
Country: USA
Study Area:
Name of Journal: BIOLOGICAL PSYCHIATRY
Language: English
Country of Authors: [Heerey, Erin A.] Bangor Univ, Sch Psychol, Bangor LL57 2AS, Gwynedd, Wales; [Bell-Warren, Kimberly R.; Gold, James M.] Univ Maryland, Maryland Psychiat Res Ctr, Baltimore, MD 21201 USA
Press Adress: Heerey, EA (reprint author), Bangor Univ, Sch Psychol, Brigantia Bldg, Bangor LL57 2AS, Gwynedd, Wales.
Email Address: e.heerey@bangor.ac.uk
Citaion:
Funding:
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Number of Citaion: 76
Publication: ELSEVIER SCIENCE INC
City of Publication: NEW YORK
Address of Publication: 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
ISSN: 0006-3223
29-Character Source Abbreviation: BIOL PSYCHIAT
ISO Source Abbreviation: Biol. Psychiatry
Volume: 64
Version: 1
Start of File: 62
End of File: 69
DOI: 10.1016/j.biopsych.2008.02.015
Number of Pages: 8
Web of Science Category: Neurosciences; Psychiatry
Subject Category: Neurosciences & Neurology; Psychiatry
Document Delivery Number: 314CE
Unique Article Identifier: WOS:000256785500009
[이 게시물은 HyeJung Mo…님에 의해 2015-05-20 18:06:47 GAMBLING에서 이동 됨]
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