위험관리 | Cases and Studies of Risk Management in Lottery & Gambling | 危險管理
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- Article] Preserved hippocampal function during learning in the context of risk in adolescent suicide attempt
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DocNo of ILP: 815
Doc. Type: Article
Title: Preserved hippocampal function during learning in the context of risk in adolescent suicide attempt
Authors: Pan, L; Segreti, A; Almeida, J; Jollant, F; Lawrence, N; Brent, D; Phillips, M
Full Name of Authors: Pan, Lisa; Segreti, AnnaMaria; Almeida, Jorge; Jollant, Fabrice; Lawrence, Natalia; Brent, David; Phillips, Mary
Keywords by Author: Adolescence; Suicide; Decision-making; Hippocampus
Keywords Plus: MAJOR DEPRESSIVE DISORDER; DECISION-MAKING; BIPOLAR DISORDER; PREFRONTAL CORTEX; ANGRY FACES; BEHAVIOR; AMYGDALA; CLASSIFICATION; RELIABILITY; ACTIVATION
Abstract: Impairment in decision-making is frequently observed in suicide attempters. Little is known, however, about neural circuitry underlying decision-making in adolescent attempters. Functional magnetic resonance imaging (fMRI) was used to assess decision-making and learning-related neural activity during Iowa Gambling Task (IGT) performance in adolescents with depression and suicide attempt (ATT, n=15), non-attempters with depression (NAT, n=14), and healthy controls (HC, n=13). ATT performed best on the IGT. A three group by two condition (high-risk versus low-risk) by three IGT block (each of 20 cards) whole-brain analysis (p < 0.05, corrected) interaction was found in the left hippocampal, frontal and temporal cortical, striatal and thalamic regions. Post-hoc analyses revealed that during low-risk decisions in blocks 2 and 3, NAT, but not ATT, showed greater left hippocampal activation versus HC (p=0.0004, p = 0.003); in block 2, during low-risk decisions NAT showed greater left middle temporal gyral activation versus HC (p=0.003); in block 3, during high-risk decisions ATT showed less activation in the right thalamus versus NAT (p=0.001) and during low risk decisions ATT showed greater activation than HC in the left caudate (p=0.002). NAT, but not ATT are differentiated from HC during performance of the IGT. Functional abnormalities in neural circuitry implicated in learning in the context of risk may underlie risk for MDD, but not risk for suicide attempt, in adolescence. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Cate of OECD: Clinical medicine
Year of Publication: 2013
Business Area: gamble
Detail Business: gamble
Country: Ireland
Study Area: adolescent, behavior, suicide, depression
Name of Journal: PSYCHIATRY RESEARCH-NEUROIMAGING
Language: English
Country of Authors: [Pan, Lisa; Segreti, AnnaMaria; Almeida, Jorge; Brent, David; Phillips, Mary] Univ Pittsburgh Sch Med, Dept Psychiat, Pittsburgh, PA USA; [Jollant, Fabrice] McGill Univ, Dept Psychiat, Douglas Inst, Montreal, PQ, Canada; [Lawrence, Natalia; Phillips, Mary] Cardiff Univ, Sch Med, Dept Psychol Med, Cardiff CF10 3AX, S Glam, Wales
Press Adress: Pan, L (reprint author), 121 Meyran Ave,Room 304, Pittsburgh, PA 15213 USA.
Email Address: thomasla@upmc.edu
Citaion:
Funding: American Foundation for Suicide Prevention; Klingenstein Third Generation Foundation Fellowship for Adolescent Depression; NIMH/NICHD [1K23MH082884]; NIH [MH66775, MH65368, MH56612, MH18951]; NIMH [MH076971]
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Number of Citaion: 45
Publication: ELSEVIER IRELAND LTD
City of Publication: CLARE
Address of Publication: ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
ISSN: 0925-4927
29-Character Source Abbreviation: PSYCHIAT RES-NEUROIM
ISO Source Abbreviation: Psychiatry Res. Neuroimaging
Volume: 211
Version: 2
Start of File: 112
End of File: 118
DOI: 10.1016/j.pscychresns.2012.07.008
Number of Pages: 7
Web of Science Category: Clinical Neurology; Neuroimaging; Psychiatry
Subject Category: Neurosciences & Neurology; Psychiatry
Document Delivery Number: 115RA
Unique Article Identifier: WOS:000316828400003
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