위험관리 | Cases and Studies of Risk Management in Lottery & Gambling | 危險管理
- date : 2015-05-20 01:10|hit : 1850
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- Article] Disruption of right prefrontal cortex by low-frequency repetitive transcranial magnetic stimulation induces risk-taking behavior
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DocNo of ILP: 4759
Doc. Type: Article
Title: Disruption of right prefrontal cortex by low-frequency repetitive transcranial magnetic stimulation induces risk-taking behavior
Authors: Knoch, D; Gianotti, LRR; Pascual-Leone, A; Treyer, V; Regard, M; Hohmann, M; Brugger, P
Full Name of Authors: Knoch, D; Gianotti, LRR; Pascual-Leone, A; Treyer, V; Regard, M; Hohmann, M; Brugger, P
Keywords by Author: decision-making; dorsolateral prefrontal cortex; inhibitory control; laterality; transcranial magnetic stimulation; risk-taking
Keywords Plus: SOMATIC MARKER HYPOTHESIS; DECISION-MAKING; DAMAGE; WILLPOWER; INFERIOR
Abstract: Decisions require careful weighing of the risks and benefits associated with a choice. Some people need to be offered large rewards to balance even minimal risks, whereas others take great risks in the hope for an only minimal benefit. We show here that risk-taking is a modifiable behavior that depends on right hemisphere prefrontal activity. We used low-frequency, repetitive transcranial magnetic stimulation to transiently disrupt left or right dorsolateral prefrontal cortex (DLPFC) function before applying a well known gambling paradigm that provides a measure of decision-making under risk. Individuals displayed significantly riskier decision-making after disruption of the right, but not the left, DLPFC. Our findings suggest that the right DLPFC plays a crucial role in the suppression of superficially seductive options. This confirms the asymmetric role of the prefrontal cortex in decision-making and reveals that this fundamental human capacity can be manipulated in normal subjects through cortical stimulation. The ability to modify risk-taking behavior may be translated into therapeutic interventions for disorders such as drug abuse or pathological gambling.
Cate of OECD: Basic medicine
Year of Publication: 2006
Business Area: gamble
Detail Business: gamble
Country: USA
Study Area:
Name of Journal: JOURNAL OF NEUROSCIENCE
Language: English
Country of Authors: Univ Zurich Hosp, Dept Neurol, CH-8091 Zurich, Switzerland; Univ Zurich Hosp, PET Ctr, Div Nucl Med, CH-8091 Zurich, Switzerland; Univ Hosp Psychiat, KEY Inst Brain Mind Res, CH-8032 Zurich, Switzerland; Harvard Univ, Sch Med, Ctr Noninvas Brain Stimulat, Boston, MA 02215 USA; Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
Press Adress: Knoch, D (reprint author), Univ Zurich Hosp, Dept Neurol, Frauenklin Str 26, CH-8091 Zurich, Switzerland.
Email Address: daria.knoch@usz.ch
Citaion:
Funding:
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Number of Citaion: 28
Publication: SOC NEUROSCIENCE
City of Publication: WASHINGTON
Address of Publication: 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
ISSN: 0270-6474
29-Character Source Abbreviation: J NEUROSCI
ISO Source Abbreviation: J. Neurosci.
Volume: 26
Version: 24
Start of File: 6469
End of File: 6472
DOI: 10.1523/JNEUROSCI.0804-06.2006
Number of Pages: 4
Web of Science Category: Neurosciences
Subject Category: Neurosciences & Neurology
Document Delivery Number: 054KQ
Unique Article Identifier: WOS:000238375900010
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