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- Article] Plasma apolipoproteins and risk for age related maculopathy
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DocNo of ILP: 4687
Doc. Type: Article
Title: Plasma apolipoproteins and risk for age related maculopathy
Authors: Dashti, N; McGwin, G; Owsley, C; Curcio, CA
Full Name of Authors: Dashti, N.; McGwin, G.; Owsley, C.; Curcio, C. A.
Keywords by Author:
Keywords Plus: CORONARY-ARTERY DISEASE; BASAL LAMINAR DEPOSIT; BEAVER DAM EYE; NUTRITION EXAMINATION SURVEY; FACTOR-H POLYMORPHISM; HUMAN BRUCHS MEMBRANE; HIGH-FAT DIET; MACULAR DEGENERATION; CARDIOVASCULAR-DISEASE; HEPG2 CELLS
Abstract: Aim: To determine if elevated plasma levels of atherogenic and/or anti-atherogenic lipoproteins are risk factors for developing age related maculopathy (ARM). Methods: In a cross sectional study in a university clinic setting, 129 patients (72 women and 57 men) underwent colour fundus photography, acuity and contrast sensitivity assessment, and electroimmuno-assays of plasma apolipoproteins B (apoB) and A-I (apoA-I), the principal proteins of low density and high density lipoproteins, respectively. Maculopathy stage was assigned using the AREDS grading system. Results: Levels of apoB in no ARM, mild, intermediate, and advanced ARM groups were 93.3, 91.8, 95.2, and 98.2 mg/dl, respectively. Levels of apoA-I were 147.4, 148.6, 141.0, and 144.9 mg/dl in the same groups. There was no significant association between these measures, typical for age, and maculopathy stage. Conclusion: Although drusen associated with ARM and ageing contain cholesterol and apoB, like the lipid rich core of an atherosclerotic plaque, the results of this study and our previous work in toto make the prospects of a plasma origin for these lesion constituents increasingly untenable. This conclusion is consistent with an emerging hypothesis that a large lipoprotein of intraocular origin is an important pathway for constituent retinal lipid processing and the biogenesis of drusen.
Cate of OECD: Clinical medicine
Year of Publication: 2006
Business Area: other
Detail Business: medicine & science
Country: England
Study Area: interview, interview, patient, risk, disease
Name of Journal: BRITISH JOURNAL OF OPHTHALMOLOGY
Language: English
Country of Authors: Univ Alabama, Sch Med, Callahan Eye Fdn Hosp, Dept Ophthalmol, Birmingham, AL 35294 USA; Univ Alabama, Dept Med, Atherosclerosis Res Unit, Sch Med,Div Geriatr & Gerontol, Birmingham, AL 35294 USA
Press Adress: Curcio, CA (reprint author), Univ Alabama, Sch Med, Callahan Eye Fdn Hosp, Dept Ophthalmol, 700 S 18th St Room H020a, Birmingham, AL 35294 USA.
Email Address: curcio@uab.edu
Citaion:
Funding:
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Number of Citaion: 92
Publication: B M J PUBLISHING GROUP
City of Publication: LONDON
Address of Publication: BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
ISSN: 0007-1161
29-Character Source Abbreviation: BRIT J OPHTHALMOL
ISO Source Abbreviation: Br. J. Ophthalmol.
Volume: 90
Version: 8
Start of File: 1028
End of File: 1033
DOI: 10.1136/bjo.2006.093856
Number of Pages: 6
Web of Science Category: Ophthalmology
Subject Category: Ophthalmology
Document Delivery Number: 064TC
Unique Article Identifier: WOS:000239111000029
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