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- Article] Risky decisions and response reversal: is there evidence of orbitofrontal cortex dysfunction in psychopathic individuals?
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DocNo of ILP: 6360
Doc. Type: Article
Title: Risky decisions and response reversal: is there evidence of orbitofrontal cortex dysfunction in psychopathic individuals?
Authors: Mitchell, DGV; Colledge, E; Leonard, A; Blair, RJR
Full Name of Authors: Mitchell, DGV; Colledge, E; Leonard, A; Blair, RJR
Keywords by Author: decision-making; gambling task; risk; response inhibition; intradimensional/extradimensional shifts; response modulation
Keywords Plus: VENTROMEDIAL PREFRONTAL CORTEX; FACIAL exPRESSIONS; CRIMINAL PSYCHOPATHS; BASOLATERAL AMYGDALA; NEURAL RESPONSES; STARTLE REFLEX; DISTRESS CUES; EMOTION; DAMAGE; TENDENCIES
Abstract: This study investigates the performance of psychopathic individuals on tasks believed to be sensitive to dorsolateral prefrontal and orbitofrontal cortex (OFC) functioning. Psychopathic and non-psychopathic individuals, as defined by the Hare psychopathy checklist revised (PCL-R) [Hare, The Hare psychopathy checklist revised, Toronto, Ontario: Multi-Health Systems, 1991] completed a gambling task [Cognition 50 (1994) 7] and the intradimensional/extradimensional (ID/ED) shift task [Nature 380 (1996) 69]. On the gambling task, psychopathic participants showed a global tendency to choose disadvantageously. Specifically, they showed an impaired ability to show learning over the course of the task. On the ID/ED task, the performance of psychopathic individuals was not significantly different from incarcerated controls on attentional set-shifting, but significant impairments were found on response reversal. These results are interpreted with reference to an OFC and amygdala dysfunction explanation of psychopathy. Crown Copyright (C) 2002 Published by Elsevier Science Ltd. All rights reserved.
Cate of OECD: Psychology
Year of Publication: 2002
Business Area: gamble
Detail Business: gamble
Country: England
Study Area: regulation, control, globalization, globalization, personal, decision, risk
Name of Journal: NEUROPSYCHOLOGIA
Language: English
Country of Authors: HMP Wormwood Scrubs, Dept Psychol, London, England; UCL, Dept Psychol, London, England; UCL, Inst Cognit Neurosci, London, England
Press Adress: Blair, RJR (reprint author), NIMH, 15 K North Dr,MSC 2670, Bethesda, MD 20892 USA.
Email Address: blairj@intra.nimh.nih.gov
Citaion:
Funding:
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Number of Citaion: 71
Publication: PERGAMON-ELSEVIER SCIENCE LTD
City of Publication: OXFORD
Address of Publication: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
ISSN: 0028-3932
29-Character Source Abbreviation: NEUROPSYCHOLOGIA
ISO Source Abbreviation: Neuropsychologia
Volume: 40
Version: 12
Start of File: 2013
End of File: 2022
DOI: 10.1016/S0028-3932(02)00056-8
Number of Pages: 10
Web of Science Category: Behavioral Sciences; Neurosciences; Psychology, Experimental
Subject Category: Behavioral Sciences; Neurosciences & Neurology; Psychology
Document Delivery Number: 601AJ
Unique Article Identifier: WOS:000178423700016
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