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- Article; Proceedings Paper] Desmopressin has an influence on the arousability of children with primary nocturnal enuresis
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DocNo of ILP: 5644
Doc. Type: Article; Proceedings Paper
Title: Desmopressin has an influence on the arousability of children with primary nocturnal enuresis
Authors: Eggert, P; Fritz, A; Stecker, B; Muller, D
Full Name of Authors: Eggert, P; Fritz, A; Stecker, B; Muller, D
Keywords by Author: desmopressin; enuresis
Keywords Plus: SLEEP; VASOPRESSIN
Abstract: Purpose: Several studies provide evidence regarding the effect of desmopressin (DDAVP) on the sleep of adults. Therefore, we investigate whether this effect has a role in children with primary nocturnal enuresis treated intranasally with DDAVP. Materials and Methods: A prospective, randomized, placebo controlled, double-blind, crossover study was performed. Patients were assigned to 2 groups by lottery. Arousability was determined by a special bell apparatus with an adjustable sound pressure level. The wet nights per week and the results of the arousal tests were compared using the signed rank test. Results: A total of 20 children with primary nocturnal enuresis 6 to 15 years old were enrolled in the study, 2 of whom had to be excluded. There were no marked differences in age or weight between the groups. The number of wet nights per week decreased significantly with DDAVP treatment. Moreover 14 patients slept more soundly with DDAVP and only 4 were more difficult to awake after the medication. This difference was significant. Conclusions: This study revealed an effect of DDAVP on arousability of enuretic children as well as its previously known action for the treatment of primary nocturnal enuresis. This result is consistent with the known action of DDAVP on sleep of elderly adults. It suggests that the cause of primary nocturnal enuresis lies in the structure of sleep of the affected patients.
Cate of OECD: Clinical medicine
Year of Publication: 2004
Business Area: lottery
Detail Business: lottery
Country: USA
Study Area:
Name of Journal: JOURNAL OF UROLOGY
Language: English
Country of Authors: Univ Kiel, Klin Allgemeine Padiat, Kiel, Germany; Charite Childrens Hosp, Berlin, Germany
Press Adress: Eggert, P (reprint author), Christian Albrechts Univ Kiel Klinikum, Klin Allgemeine Pediat, Schwanenweg 20, D-24105 Kiel, Germany.
Email Address: p.eggert@pediatrics.uni-kiel.de
Citaion:
Funding:
Lists of Citation: BORN J, 1992, AM J PHYSIOL, V262, pE295; BOYD MMM, 1960, J PSYCHOSOM RES, V4, P274, DOI 10.1016/0022-3999(60)90003-9; CARPENTER R, 1994, DISORDERS ELIMINATIO, P748; COURTIN W, 1923, ARCH KINDERHEILKD, V73, P40; DITMAN KS, 1955, AM J PSYCHIAT, V3, P913; Eggert P, 1995, ARCH DIS CHILD, V73, P508; FEFFERMAN RA, 1994, PEDIATRICS, V93, P1022; Kohyama J, 2000, EUR UROL, V38, P631, DOI 10.1159/000020344; Muller D, 2002, LANCET, V360, P642, DOI 10.1016/S0140-6736(02)09792-1; Muller D, 2001, J UROLOGY, V166, P2432, DOI 10.1016/S0022-5347(05)65609-1; Neveus T, 1999, PEDIATRICS, V103, P1193, DOI 10.1542/peds.103.6.1193; Perras B, 1996, PEPTIDES, V17, P1253, DOI 10.1016/S0196-9781(96)00173-8; Reim?o R, 1993, Arq Neuropsiquiatr, V51, P41; Rittig S, 1989, AM J PHYSIOL, V256, P664; SPATHSCHWALBE E, 1994, NEUROENDOCRINOLOGY, V60, P544, DOI 10.1159/000126793; TROUSSEAU A, 1868, INCONTINENCE NOCTURN; Wolfish NM, 1997, ACTA PAEDIATR, V86, P381, DOI 10.1111/j.1651-2227.1997.tb09027.x; Yeung CK, 2002, BJU INT, V90, P302, DOI 10.1046/j.1464-410X.2002.02884.x
Number of Citaion: 18
Publication: LIPPINCOTT WILLIAMS & WILKINS
City of Publication: PHILADELPHIA
Address of Publication: 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
ISSN: 0022-5347
29-Character Source Abbreviation: J UROLOGY
ISO Source Abbreviation: J. Urol.
Volume: 171
Version: 6
Start of File: 2586
End of File: 2588
DOI: 10.1097/01.ju.0000108740.00453.b0
Number of Pages: 3
Web of Science Category: Urology & Nephrology
Subject Category: Urology & Nephrology
Document Delivery Number: 822BW
Unique Article Identifier: WOS:000221510400009
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