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- Article] INDUCTION OF CONTROLLED PROSTATIC TISSUE NECROSIS BY BACILLE CALMETTE-GUERIN DERIVATIVES
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DocNo of ILP: 8545
Doc. Type: Article
Title: INDUCTION OF CONTROLLED PROSTATIC TISSUE NECROSIS BY BACILLE CALMETTE-GUERIN DERIVATIVES
Authors: MORALES, A; NICKEL, JC; MANLEY, PN
Full Name of Authors: MORALES, A; NICKEL, JC; MANLEY, PN
Keywords by Author:
Keywords Plus: BCG; IMMUNOTHERAPY; CANCER; CELLS
Abstract: Intraprostatic administration of live bacille Calmette-Guerin (BCG) in humans has been found to produce tumor necrosis; unfortunately, the number of severity of complications have made its clinical use prohibitive. Previous studies have shown that soluble and microparticulate components present in the supernatants obtained after centrifugation of a reconstituted BCG preparation exhibit similar immunogenicity to the one shown by live bacteria. The supernatants, however, are not associated with disseminated infection of the progressive regional tissue destruction observed with the use of viable vaccine. Experiments were conducted to determine the effect of intraprostatic injection of BCG and its supernatants. Adult dogs, after positive conversion to protein purified derivative (PPD), were randomly assigned to three groups. Under direct vision and with digital rectal control, intraprostatic injections of various agents were given as follows: group I, normal saline; group II, live BCG; group III, 200-mu-g of BCG supernatants. Two months later the animals were sacrificed, and the prostates removed in toto and submitted for a thorough histological examination. Extensive but variable tissue necrosis was noted in groups II and III. No histological alterations were present in group I. The histological picture of the animals receiving BCG supernatants conclusively demonstrated circumscribed necrosis of the gland. Side effects and complications were present in animals receiving live BCG but conspicuously absent in the ones receiving supernatants. The observed effectiveness and safety of BCG supernatants for intraprostatic administration in an experimental system may lead to a simple, safe, and efficacious therapeutic modality for localized carcinoma of the prostate in humans.
Cate of OECD: Clinical medicine
Year of Publication: 1991
Business Area: other
Detail Business: medicine & science
Country: USA
Study Area:
Name of Journal: UROLOGICAL RESEARCH
Language: English
Country of Authors: QUEENS UNIV,DEPT PATHOL,KINGSTON K7L 2V7,ONTARIO,CANADA
Press Adress: MORALES, A (reprint author), QUEENS UNIV,DEPT UROL,KINGSTON K7L 2V7,ONTARIO,CANADA.
Email Address:
Citaion:
Funding:
Lists of Citation: FLOCKS RH, 1952, J UROLOGY, V68, P510; LAGRANGE PH, 1976, BCG CANCER IMMUNOTHE, P23; LOWRY OH, 1951, J BIOL CHEM, V193, P265; Merrin C, 1973, Urology, V2, P651, DOI 10.1016/0090-4295(73)90328-2; MILLER TE, 1973, J NATL CANCER I, V51, P1669; MORALES A, 1986, WORLD J UROL, V3, P209, DOI 10.1007/BF00632180; NICKEL J C, 1985, Journal of Urology, V133, p268A; NICKEL J C, 1989, Journal of Urology, V141, p291A; PANG ASD, 1982, J UROLOGY, V127, P1225; ROBINSON MRG, 1977, BR J UROL, V44, P221; ROSENTHAL SR, 1980, BCG VACCINE TUBERCUL, P44; WEISS DW, 1976, MED CLIN N AM, V60, P473; WILSON JWL, 1983, CAN J SURG, V26, P363
Number of Citaion: 13
Publication: SPRINGER VERLAG
City of Publication: NEW YORK
Address of Publication: 175 FIFTH AVE, NEW YORK, NY 10010
ISSN: 0300-5623
29-Character Source Abbreviation: UROL RES
ISO Source Abbreviation: Urol. Res.
Volume: 19
Version: 1
Start of File: 35
End of File: 38
DOI:
Number of Pages: 4
Web of Science Category: Urology & Nephrology
Subject Category: Urology & Nephrology
Document Delivery Number: EZ580
Unique Article Identifier: WOS:A1991EZ58000007
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