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- Review] Safety margins for the primary surgical excison of malignant melanoma. Proposals based on controlled clinical trials
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DocNo of ILP: 6402
Doc. Type: Review
Title: Safety margins for the primary surgical excison of malignant melanoma. Proposals based on controlled clinical trials
Authors: Hauschild, A; Eiling, S; Lischner, S; Haacke, TC; Christophers, E
Full Name of Authors: Hauschild, A; Eiling, S; Lischner, S; Haacke, TC; Christophers, E
Keywords by Author: melanoma; surgery; resection margins; local recurrence; metastasis
Keywords Plus: THIN CUTANEOUS MELANOMA; RESECTION MARGIN; PROGNOSTIC FACTORS; LOCAL RECURRENCE; TUMOR THICKNESS; RISK; MM; MANAGEMENT; COMMITTEE; SURVIVAL
Abstract: Excisional biopsy is recommended as the procedure of choice whenever there: is suspicion of malignant melanoma. Incisional biopsies are only rarely indicated. For nearly seventy years the debate about the opti- mum resection safety, margin around the primary tumor was influenced by historical case reports and paradigms. Recently controlled clinical studies have provided new insights. Accumulating evidence over the last two decades shows that narrower surgical margins influence neither the rate of satellites or tn-transit-metastases nor the occurrence of advanced metastatic disease. Local recurrences is: rare (approx. 0.1%) when, primary tumors are thin and is seen more often (approx. 10%) in primary, tumors of greater thickness(> 4mm). Analysis of the overall survival in randomized trials shows equal prognosis for malignant melanoma for narrow and wide resection margins. Due to these findings in-toto excisional biopsy for in-situ melanomal, a resection margin of 1 cm for thin primary tumors (<1 cm tumor thickness). and a resection margin of 1 to 2 cm for primary tumors. greater than 1, mm appears sufficient. With, these recommendations, primary closure of wounds will be possible in nearly, all cases reducing surgical costs and morbidity. This article should serve as a basis of discussion for the proposed revision of the current guidelines of the German Dermatologic. Society (DDG) on the primary surgical care of melanoma patients.
Cate of OECD: Clinical medicine
Year of Publication: 2001
Business Area: other
Detail Business: medicine & science
Country: USA
Study Area:
Name of Journal: HAUTARZT
Language: German
Country of Authors: Univ Kiel, Klin Dermatol Venereol & Allergol, Hautklin, D-24105 Kiel, Germany
Press Adress: Hauschild, A (reprint author), Univ Kiel, Klin Dermatol Venereol & Allergol, Hautklin, Schittenhelmstr 7, D-24105 Kiel, Germany.
Email Address:
Citaion:
Funding:
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Number of Citaion: 46
Publication: SPRINGER-VERLAG
City of Publication: NEW YORK
Address of Publication: 175 FIFTH AVE, NEW YORK, NY 10010 USA
ISSN: 0017-8470
29-Character Source Abbreviation: HAUTARZT
ISO Source Abbreviation: Hautarzt
Volume: 52
Version: 11
Start of File: 1003
End of File: 1010
DOI: 10.1007/s001050170034
Number of Pages: 8
Web of Science Category: Dermatology
Subject Category: Dermatology
Document Delivery Number: 495PY
Unique Article Identifier: WOS:000172350600003
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