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- Review] Coral aquaculture to support drug discovery
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DocNo of ILP: 417
Doc. Type: Review
Title: Coral aquaculture to support drug discovery
Authors: Leal, MC; Calado, R; Sheridan, C; Alimonti, A; Osinga, R
Full Name of Authors: Leal, Miguel C.; Calado, Ricardo; Sheridan, Christopher; Alimonti, Andrea; Osinga, Ronald
Keywords by Author: Cnidaria; biomass supply; bioactive compounds; microbiota; economic feasibility
Keywords Plus: REEF RESTORATION; NATURAL-PRODUCTS; SINULARIA-FLEXIBILIS; CULTIVATION; GROWTH; MUCUS; BACTERIA; DISEASES; ECOLOGY; SPONGES
Abstract: Marine natural products (NP) are unanimously acknowledged as the 'blue gold' in the urgent quest for new pharmaceuticals. Although corals are among the marine organisms with the greatest diversity of secondary metabolites, growing evidence suggest that their symbiotic bacteria produce most of these bioactive metabolites. The ex hospite culture of coral symbiotic microbiota is extremely challenging and only limited examples of successful culture exist today. By contrast, in toto aquaculture of corals is a commonly applied technology to produce corals for aquaria. Here, we suggest that coral aquaculture could as well be a viable and economically feasible option to produce the biomass required to execute the first steps of the NP-based drug discovery pipeline.
Cate of OECD: Environmental biotechnology
Year of Publication: 2013
Business Area: other
Detail Business: medicine & science
Country: England
Study Area: development, development, drug, disease
Name of Journal: TRENDS IN BIOTECHNOLOGY
Language: English
Country of Authors: [Leal, Miguel C.; Calado, Ricardo] Univ Aveiro, Dept Biol, P-3810193 Aveiro, Portugal; [Leal, Miguel C.; Calado, Ricardo] Univ Aveiro, CESAM, P-3810193 Aveiro, Portugal; [Leal, Miguel C.] Skidaway Inst Oceanog, Savannah, GA 31411 USA; [Sheridan, Christopher] Univ Mons, Res Inst Biosci, Biol Marine Organisms & Biomimet Lab, B-7000 Mons, Belgium; [Alimonti, Andrea] Oncol Inst Southern Switzerland, CH-6500 Bellinzona, Switzerland; [Osinga, Ronald] Wageningen Univ, NL-6700 AH Wageningen, Netherlands; [Osinga, Ronald] Porifarma BV, NL-6718 HT Ede, Netherlands
Press Adress: Leal, MC (reprint author), Univ Aveiro, Dept Biol, Campus Santiago, P-3810193 Aveiro, Portugal.
Email Address: miguelcleal@gmail.com
Citaion: Calado, Ricardo/0000-0002-1670-9335
Funding: Fundacao para a Ciencia e Tecnologia [SFRH/BD/63783/2009]; European Social Fund; national funds MOTES; National Fund for Scientific Research (FNRS) [F3/5/5-A2/5-MCF/DM-A115]
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Number of Citaion: 50
Publication: ELSEVIER SCIENCE LONDON
City of Publication: LONDON
Address of Publication: 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
ISSN: 0167-7799
29-Character Source Abbreviation: TRENDS BIOTECHNOL
ISO Source Abbreviation: Trends Biotechnol.
Volume: 31
Version: 10
Start of File: 555
End of File: 561
DOI: 10.1016/j.tibtech.2013.06.004
Number of Pages: 7
Web of Science Category: Biotechnology & Applied Microbiology
Subject Category: Biotechnology & Applied Microbiology
Document Delivery Number: 231WP
Unique Article Identifier: WOS:000325449400003
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