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- Article; Proceedings Paper] A randomized double-blind fluvoxamine/placebo crossover trial in pathologic gambling
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DocNo of ILP: 6772
Doc. Type: Article; Proceedings Paper
Title: A randomized double-blind fluvoxamine/placebo crossover trial in pathologic gambling
Authors: Hollander, E; DeCaria, CM; Finkell, JN; Begaz, T; Wong, CM; Cartwright, C
Full Name of Authors: Hollander, E; DeCaria, CM; Finkell, JN; Begaz, T; Wong, CM; Cartwright, C
Keywords by Author: pathologic gambling; impulsivity; SSRI; fluvoxamine; compulsive; serotonin
Keywords Plus: GAMBLERS; STUDENTS
Abstract: Background: The study assessed the efficacy and tolerability of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine in the treatment of pathologic gambling (PG). Methods: A 16-week randomized double-blind crossover design insured that each subject received 8 weeks of fluvoxamine and 8 weeks of a placebo. Fifteen patients entered and 10 subjects, all male, completed the study. Results: Fluvoxamine resulted in a significantly greater percent improvement in overall gambling severity on the PG Clinical Global Impression (PG-CGI) scale. There was a significant drug effect on gambling urge and behavior as measured by the PG modification of the Yale-Brown Obsessive Compulsive Scale and PG-CGI scale improvement scores; however, there was a significant interaction of drug effect with the order of administration of drug and placebo. Post hoc analysis, treating each phase as a separate trial, demonstrated a significant difference between fluvoxamine and the placebo in the second phase of the trial but not in the first. Fluvoxamine side effects were of only mild intensity and consistent with SSRI treatment and were not associated with early withdrawal from the study. Conclusions: These findings suggest that fluvoxamine is well tolerated and may be effective in the treatment of PG in an acute trial, and that an early placebo effect in PG treatment appears to diminish over time. To confirm this finding and to determine whether improvement persists over an extended period of time, a longer duration parallel-design trial with long-term maintenance follow-up should be conducted in a larger and more diverse PG population. Biol Psychiatry 2000;47:813-817 (C) 2000 Society of Biological Psychiatry.
Cate of OECD: Basic medicine
Year of Publication: 2000
Business Area: gamble
Detail Business: gamble
Country: USA
Study Area:
Name of Journal: BIOLOGICAL PSYCHIATRY
Language: English
Country of Authors: CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA; CUNY Mt Sinai Sch Med, Compuls Impuls & Anxiety Disorders Program, New York, NY 10029 USA
Press Adress: Hollander, E (reprint author), CUNY Mt Sinai Sch Med, Dept Psychiat, Box 1230,1 Gustave Levy Pl, New York, NY 10029 USA.
Email Address:
Citaion:
Funding:
Lists of Citation: Black DW, 1996, J CLIN PSYCHIAT, V57, P50; CARRASCO JL, 1994, ACTA PSYCHIAT SCAND, V90, P427, DOI 10.1111/j.1600-0447.1994.tb01619.x; DeCaria CM, 1996, J CLIN PSYCHIAT, V57, P80; Hollander E, 1998, AM J PSYCHIAT, V155, P1781; Hollander E, 1993, OBSESSIVE COMPULSIVE; Ladouceur R, 1998, BEHAV RES THER, V36, P1111, DOI 10.1016/S0005-7967(98)00086-2; LESIEUR HR, 1987, AM J PSYCHIAT, V144, P1184; LESIEUR HR, 1987, ADDICT BEHAV, V12, P129, DOI 10.1016/0306-4603(87)90019-0; LESIEUR HR, 1991, ADDICT BEHAV, V16, P517, DOI 10.1016/0306-4603(91)90059-Q; LESTER D, 1994, INT J ADDICT, V29, P1611; Moreno IS-RJ, 1991, HUMAN PSYCHOPHARMA S, V6, P9; *NAT COUNC PROBL G, 1997, NAT COUNC PROBL GAMB; Shaffer H J, 1996, J Gambl Stud, V12, P193, DOI 10.1007/BF01539174; STEWART RM, 1988, BRIT J PSYCHIAT, V152, P284, DOI 10.1192/bjp.152.2.284; VOLBERG RA, 1994, AM J PUBLIC HEALTH, V84, P237, DOI 10.2105/AJPH.84.2.237
Number of Citaion: 15
Publication: ELSEVIER SCIENCE INC
City of Publication: NEW YORK
Address of Publication: 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA
ISSN: 0006-3223
29-Character Source Abbreviation: BIOL PSYCHIAT
ISO Source Abbreviation: Biol. Psychiatry
Volume: 47
Version: 9
Start of File: 813
End of File: 817
DOI: 10.1016/S0006-3223(00)00241-9
Number of Pages: 5
Web of Science Category: Neurosciences; Psychiatry
Subject Category: Neurosciences & Neurology; Psychiatry
Document Delivery Number: 312DW
Unique Article Identifier: WOS:000086928800006
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