심리적도박 | Cases and Studies in Pathological Gambling | 游戏设计
- date : 2015-05-20 01:10|hit : 1884
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- Article] An open naltrexone treatment study in pathological gambling disorder
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DocNo of ILP: 6438
Doc. Type: Article
Title: An open naltrexone treatment study in pathological gambling disorder
Authors: Kim, SW; Grant, JE
Full Name of Authors: Kim, SW; Grant, JE
Keywords by Author: naltrexone; opioid antagonists; pathological gambling disorder; urges
Keywords Plus: SHORT-TERM; ANTAGONISTS
Abstract: The present study was designed to test the short-term efficacy and safety of naltrexone in the treatment of pathological gambling disorder. Seventeen subjects (seven men, 10 women) who fulfilled DSM-IV criteria for pathological gambling disorder, and were free from other Axis I diagnoses by Structured Clinical Interview for DSM-III-R screening, participated in a 6-week open naltrexone flexible dose trial. Gambling symptom change was assessed with the patient-rated Clinical Global Impression (CGI) Scale, the clinician-rated CGI and the Gambling Symptom Assessment Scale. Side-effects were monitored weekly and liver function tests biweekly. Naltrexone reduced urges to gamble and gambling behaviour. The mean change in gambling frequency per week was 1.40 +/- 0.28 episodes per week; the mean change in dollars lost per week was $66.95 +/- 13.77; and the mean change in clinician-rated CGI Improvement was 0.40 +/- 0.04. Of those who responded to the medication, the majority had done so by the end of the fourth week. Men responded to naltrexone as well as women. The average naltrexone dose required for effective symptom control was 157 mg/day. Nausea was common during the first week (47%). The present findings provide evidence that naltrexone may be effective in the treatment of pathological gambling disorder. The present report is preliminary and controlled trials are needed to confirm these findings. Int Clin Psychopharmacol 16:285-289 (C) 2001 Lippincott Williams & Wilkins.
Cate of OECD: Basic medicine
Year of Publication: 2001
Business Area: gamble
Detail Business: gamble
Country: USA
Study Area:
Name of Journal: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
Language: English
Country of Authors: Univ Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
Press Adress: Kim, SW (reprint author), Univ Minnesota, Sch Med, Dept Psychiat, F256-2A W,2450 Riverside Ave, Minneapolis, MN 55455 USA.
Email Address:
Citaion:
Funding:
Lists of Citation: CORRIGALL WA, 1991, PSYCHOPHARMACOLOGY, V104, P167, DOI 10.1007/BF02244173; Covey LS, 1999, J ADDICT DIS, V18, P31; Crockford DN, 1998, CAN J PSYCHIAT, V43, P86; Croop RS, 1997, ARCH GEN PSYCHIAT, V54, P1130; GIBBONS RD, 1993, ARCH GEN PSYCHIAT, V50, P739; Guy W, 1976, ECDEU ASSESSMENT MAN, P218; HALLER R, 1994, PHARMACOPSYCHIATRY, V27, P129, DOI 10.1055/s-2007-1014292; HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56; HAMILTON M, 1959, BRIT J MED PSYCHOL, V32, P50; HEDEKER D, 1993, MIXREG FORTRAN PROGR; HERMAN BH, 1984, LIFE SCI, V34, P1, DOI 10.1016/0024-3205(84)90324-2; Hollander E, 2000, BIOL PSYCHIAT, V47, P813, DOI 10.1016/S0006-3223(00)00241-9; Hollander E, 1998, AM J PSYCHIAT, V155, P1781; HOLLANDER E, 1992, AM J PSYCHIAT, V149, P710; Kim SW, 1998, J CLIN PSYCHIAT, V59, P159; KIM SW, 2001, IN PRESS J CLIN PSYC; KLEBER HD, 1985, BIOL PSYCHIAT, V20, P66, DOI 10.1016/0006-3223(85)90136-2; Kreek MJ, 1999, J PHARMACOL EXP THER, V288, P260; LESIEUR HR, 1987, AM J PSYCHIAT, V144, P1184; MITCHELL JE, 1987, BIOL PSYCHIAT, V22, P35, DOI 10.1016/0006-3223(87)90127-2; *NRCC, 1978, ARCH GEN PSYCHIAT, V35, P335; Pfohl D N, 1986, NIDA Res Monogr, V67, P66; Shaffer HJ, 1999, AM J PUBLIC HEALTH, V89, P1369, DOI 10.2105/AJPH.89.9.1369; Sonne S, 1996, J NERV MENT DIS, V184, P192, DOI 10.1097/00005053-199603000-00011; Spitzer R. L., 1990, STRUCTURED CLIN INTE; Stromberg MF, 1998, ALCOHOL CLIN EXP RES, V22, P2186, DOI 10.1111/j.1530-0277.1998.tb05932.x; VEREBEY KG, 1985, NIDA RES MONOGR, V67, P73; VOLPICELLI JR, 1995, AM J PSYCHIAT, V152, P613
Number of Citaion: 28
Publication: LIPPINCOTT WILLIAMS & WILKINS
City of Publication: PHILADELPHIA
Address of Publication: 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
ISSN: 0268-1315
29-Character Source Abbreviation: INT CLIN PSYCHOPHARM
ISO Source Abbreviation: Int. Clin. Psychopharmacol.
Volume: 16
Version: 5
Start of File: 285
End of File: 289
DOI: 10.1097/00004850-200109000-00006
Number of Pages: 5
Web of Science Category: Pharmacology & Pharmacy; Psychiatry
Subject Category: Pharmacology & Pharmacy; Psychiatry
Document Delivery Number: 468EU
Unique Article Identifier: WOS:000170745800006
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