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- date : 2015-05-20 01:10|hit : 1704
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- Article] Decisions under risk in Parkinson's disease: Preserved evaluation of probability and magnitude
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DocNo of ILP: 331
Doc. Type: Article
Title: Decisions under risk in Parkinson's disease: Preserved evaluation of probability and magnitude
Authors: Sharp, ME; Viswanathan, J; McKeown, MJ; Appel-Cresswell, S; Stoessl, AJ; Barton, JJS
Full Name of Authors: Sharp, Madeleine E.; Viswanathan, Jayalakshmi; McKeown, Martin J.; Appel-Cresswell, Silke; Stoessl, A. Jon; Barton, Jason J. S.
Keywords by Author: Decision-making; Impulse control disorders; Parkinson's disease; Prospect theory
Keywords Plus: IMPULSE CONTROL DISORDERS; IOWA GAMBLING TASK; DOPAMINE AGONISTS; NEURAL REPRESENTATION; COGNITIVE IMPAIRMENT; MAKING IMPAIRMENTS; PARIETAL CORTEX; HUMAN BRAIN; REWARD; UNCERTAINTY
Abstract: Introduction: Unmedicated Parkinson's disease patients tend to be risk-averse while dopaminergic treatment causes a tendency to take risks. While dopamine agonists may result in clinically apparent impulse control disorders, treatment with levodopa also causes shift in behaviour associated with an enhanced response to rewards. Two important determinants in decision-making are how subjects perceive the magnitude and probability of outcomes. Our objective was to determine if patients with Parkinson's disease on or off levodopa showed differences in their perception of value when making decisions under risk. Methods: The Vancouver Gambling task presents subjects with a choice between one prospect with larger outcome and a second with higher probability. Eighteen age-matched controls and eighteen patients with Parkinson's disease before and after levodopa were tested. In the Gain Phase subjects chose between one prospect with higher probability and another with larger reward to maximize their gains. In the Loss Phase, subjects played to minimize their losses. Results: Patients with Parkinson's disease, on or off levodopa, were similar to controls when evaluating gains. However, in the Loss Phase before levodopa, they were more likely to avoid the prospect with lower probability but larger loss, as indicated by the steeper slope of their group psychometric function (t((24))=2.21, p=0.04). Modelling with prospect theory suggested that this was attributable to a 28% overestimation of the magnitude of loss, rather than an altered perception of its probability. Conclusion: While pre-medicated patients with Parkinson's disease show risk-aversion for large losses, patients on levodopa have normal perception of magnitude and probability for both loss and gain. The finding of accurate and normally biased decisions under risk in medicated patients with PD is important because it indicates that, if there is indeed anomalous risk-seeking behaviour in such a cohort, it may derive from abnormalities in components of decision making that are separate from evaluations of size and probability. (C) 2013 Elsevier Ltd. All rights reserved.
Cate of OECD: Psychology
Year of Publication: 2013
Business Area: gamble
Detail Business: gamble
Country: England
Study Area: Evaluation, probabilityperspective theory, probability, perspective theory, patient, dopamine, risk, parkinson
Name of Journal: NEUROPSYCHOLOGIA
Language: English
Country of Authors: [Sharp, Madeleine E.; Viswanathan, Jayalakshmi; Barton, Jason J. S.] Univ British Columbia, Dept Med Neurol, Human Vis & Eye Movement Lab, Vancouver, BC V5Z 1M9, Canada; [Viswanathan, Jayalakshmi; Barton, Jason J. S.] Univ British Columbia, Dept Ophthalmol, Vancouver, BC, Canada; [Viswanathan, Jayalakshmi; Barton, Jason J. S.] Univ British Columbia, Dept Visual Sci, Vancouver, BC V5Z 1M9, Canada; [McKeown, Martin J.; Appel-Cresswell, Silke; Stoessl, A. Jon] Univ British Columbia, Pacific Parkinsons Res Ctr, Vancouver, BC V5Z 1M9, Canada; [Barton, Jason J. S.] Univ British Columbia, Dept Psychol, Vancouver, BC, Canada
Press Adress: Sharp, ME (reprint author), VGH Eye Care Ctr, Neuroophthalmol Sect K, 2550 Willow St, Vancouver, BC V5Z 3N9, Canada.
Email Address: madeleinesharp@gmail.com
Citaion:
Funding: Canadian Institute of Health Research [MOP-81270]; Canada Research Chair; Marianne Koerner Chair in Brain Diseases; Ludmila and Henry Zeldowicz Award; Andre Barbeau Award
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Number of Citaion: 77
Publication: PERGAMON-ELSEVIER SCIENCE LTD
City of Publication: OXFORD
Address of Publication: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
ISSN: 0028-3932
29-Character Source Abbreviation: NEUROPSYCHOLOGIA
ISO Source Abbreviation: Neuropsychologia
Volume: 51
Version: 13
Start of File: 2679
End of File: 2689
DOI: 10.1016/j.neuropsychologia.2013.08.008
Number of Pages: 11
Web of Science Category: Behavioral Sciences; Neurosciences; Psychology, Experimental
Subject Category: Behavioral Sciences; Neurosciences & Neurology; Psychology
Document Delivery Number: 278DN
Unique Article Identifier: WOS:000328869400021
[이 게시물은 HyeJung Mo…님에 의해 2015-05-20 14:56:52 GAMBLING에서 이동 됨]
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