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- Article] RELATIONSHIP BETWEEN SCHEDULE-INDUCED-POLYDIPSIA AND AMPHETAMINE INTRAVENOUS SELF-ADMINISTRATION - INDIVIDUAL-DIFFERENCES AND ROLE OF EXPERIENCE
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DocNo of ILP: 8241
Doc. Type: Article
Title: RELATIONSHIP BETWEEN SCHEDULE-INDUCED-POLYDIPSIA AND AMPHETAMINE INTRAVENOUS SELF-ADMINISTRATION - INDIVIDUAL-DIFFERENCES AND ROLE OF EXPERIENCE
Authors: PIAZZA, PV; MITTLEMAN, G; DEMINIERE, JM; LEMOAL, M; SIMON, H
Full Name of Authors: PIAZZA, PV; MITTLEMAN, G; DEMINIERE, JM; LEMOAL, M; SIMON, H
Keywords by Author: ADDICTION; COPING; INDIVIDUAL DIFFERENCE; SCHEDULE-INDUCED POLYDIPSIA; INTRAVENOUS SELF-ADMINISTRATION; AMPHETAMINE
Keywords Plus: PITUITARY-ADRENAL ACTIVITY; NUCLEUS-ACCUMBENS; INGESTIVE BEHAVIOR; 6-HYDROXYDOPAMINE LESIONS; CORTICOSTERONE LEVELS; ADJUNCTIVE BEHAVIOR; COCAINE; RATS; VULNERABILITY; ADDICTION
Abstract: It has been suggested that drug abuse belongs to a larger class of addictive behaviors, including smoking, eating or gambling, which are mediated by common processes. Since laboratory animals can be induced to develop drug self-administration as well as indulge in compulsive eating or drinking, the present experiments were designed to find out if the same animals were susceptible to both behaviors. Only certain rats develop amphetamine intravenous self-administration (SA), and this susceptibility can be predicted from their enhanced locomotor response in a novel environment. Furthermore, excessive, non-regulatory drinking, referred to as schedule-induced polydipsia (SIP), in response to the periodic delivery of small amounts of food is only observed in certain rats. Since the propensity to SA has been shown to be influenced by experimental factors and testing for SIP was found to modify behavioral and biological parameters related to the propensity for drug-seeking, we also investigated whether experience of SIP influenced the subsequent development of SA. In Expt. 1, the rats that developed SA also acquired SIP, and had a higher locomotor response to novelty. The results of Expt. 2 showed that testing for SIP influenced the predisposition to develop amphetamine SA. When animals were tested for SIP first, the polydipsic rats subsequently failed to acquire SA, and had a reduced locomotor response to novelty. These changes seemed to be specific to the experience of SIP, as individual differences in the locomotor response to novelty were unchanged when animals were housed in standard laboratory conditions over a period of one month between the two tests. First and foremost, the results indicate that the predisposition to develop amphetamine SA is related to other behaviors with compulsive features, such as SIP. Secondly, these results demonstrate the powerful influence of a specific experience that is thought to have a coping function, in reducing or altering vulnerability to addiction.
Cate of OECD: Psychology
Year of Publication: 1993
Business Area: gamble
Detail Business: gamble
Country: Netherlands
Study Area:
Name of Journal: BEHAVIOURAL BRAIN RESEARCH
Language: English
Country of Authors:
Press Adress: PIAZZA, PV (reprint author), UNIV BORDEAUX 2,PSYCHOBIOL COMPORTEMENTS ADAPTATIFS,INSERM,U259,DOMAINE CARREIRE,F-33077 BORDEAUX,FRANCE.
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Number of Citaion: 58
Publication: ELSEVIER SCIENCE BV
City of Publication: AMSTERDAM
Address of Publication: PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
ISSN: 0166-4328
29-Character Source Abbreviation: BEHAV BRAIN RES
ISO Source Abbreviation: Behav. Brain Res.
Volume: 55
Version: 2
Start of File: 185
End of File: 193
DOI: 10.1016/0166-4328(93)90114-6
Number of Pages: 9
Web of Science Category: Behavioral Sciences; Neurosciences
Subject Category: Behavioral Sciences; Neurosciences & Neurology
Document Delivery Number: LM503
Unique Article Identifier: WOS:A1993LM50300008
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