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- Article] Compulsive eating and weight gain related to dopamine agonist use
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DocNo of ILP: 4864
Doc. Type: Article
Title: Compulsive eating and weight gain related to dopamine agonist use
Authors: Nirenberg, MJ; Waters, C
Full Name of Authors: Nirenberg, MJ; Waters, C
Keywords by Author: Parkinson's disease; dopamine agonist; compulsive eating; binge; weight gain
Keywords Plus: HEDONISTIC HOMEOSTATIC DYSREGULATION; DEEP BRAIN-STIMULATION; PARKINSONS-DISEASE; REPLACEMENT THERAPY; GENDER DIFFERENCES; DEPRESSION; PRAMIPEXOLE; BEHAVIORS; LEVODOPA
Abstract: Dopamine agonists have been implicated in causing compulsive behaviors in patients with Parkinson's disease (PD). These have included gambling, hypersexuality, hobbyism, and other repetitive, purposeless behaviors ("punding"). In this report, we describe 7 patients in whom compulsive eating developed in the context of pramipexole use. All of the affected patients had significant, undesired weight gain; 4 had other comorbid compulsive behaviors. In the 5 patients who lowered the dose of pramipexole or discontinued dopamine agonist treatment, the behavior remitted and no further weight gain occurred. Physicians should be aware that compulsive eating resulting in significant weight gain may occur in PD as a side-effect of dopamine agonist medications such as pramipexole. Given the known risks of the associated weight gain and obesity, further investigation is warranted. (C) 2005 Movement Disorder Society.
Cate of OECD: Clinical medicine
Year of Publication: 2006
Business Area: gamble
Detail Business: gamble
Country: USA
Study Area:
Name of Journal: MOVEMENT DISORDERS
Language: English
Country of Authors: Columbia Univ, Med Ctr, Dept Neurol, Div Movement Disorders, New York, NY USA
Press Adress: Nirenberg, MJ (reprint author), Weill Cornell Med Coll, Dept Neurol & Neurosci, 428 E 72nd St,Suite 400, New York, NY 10021 USA.
Email Address: mjnirenb@med.cornell.edu
Citaion:
Funding:
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Number of Citaion: 33
Publication: WILEY-LISS
City of Publication: HOBOKEN
Address of Publication: DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
ISSN: 0885-3185
29-Character Source Abbreviation: MOVEMENT DISORD
ISO Source Abbreviation: Mov. Disord.
Volume: 21
Version: 4
Start of File: 524
End of File: 529
DOI: 10.1002/mds.20757
Number of Pages: 6
Web of Science Category: Clinical Neurology
Subject Category: Neurosciences & Neurology
Document Delivery Number: 036UV
Unique Article Identifier: WOS:000237102300014
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