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- Article] The 5-HTTLPR polymorphism, impulsivity and suicide behavior in euthymic bipolar patients
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DocNo of ILP: 1809
Doc. Type: Article
Title: The 5-HTTLPR polymorphism, impulsivity and suicide behavior in euthymic bipolar patients
Authors: Malloy-Diniz, LF; Neves, FS; de Moraes, PHP; De Marco, LA; Romano-Silva, MA; Krebs, MO; Correa, H
Full Name of Authors: Malloy-Diniz, Leandro Fernandes; Neves, Fernando Silva; Paiva de Moraes, Paulo Henrique; De Marco, Luiz Armando; Romano-Silva, Marco Aurelio; Krebs, Marie-Odile; Correa, Humberto
Keywords by Author: Bipolar disorder; Suicide; Impulsivity; 5-HTTLPR; Neuropsychology; Decision-making
Keywords Plus: DECISION-MAKING; SUSTAINED ATTENTION; PORTUGUESE VERSION; DISORDER; DEPRESSION; PERFORMANCE; MECHANISM; VALIDITY; AMYGDALA; STRESS
Abstract: Background: Suicide behavior is very frequent in Bipolar Disorder (BD) and they are both closely associated with impulsivity. Furthermore they are, impulsivity, BD and suicide behavior, associated with serotonergic function, at least partially, under genetic determinism and somewhat associated with the serotonin transporter gene polymorphism, the 5-HTTLPR. We aimed to assess different impulsivity components in BD sub-grouped by suicidal attempt and healthy controls. We hypothesized that the non-planning/cognitive impulsivity, could be more closely associated with suicidal behavior. We further associated 5-HITLPR genotypes with neuropsychological results to test the hypothesis that this polymorphism is associated with cognitive impulsivity. Method: We assessed 95 euthymic bipolar patients sub-grouped by suicidal attempt history in comparison with 94 healthy controls. All subjects underwent a laboratory assessment of impulsivity (Continuous Performance Test and Iowa Gambling Test). Furthermore the genotyping of 5-HTTLPR was performed in all subjects. Results: We found that bipolar patients are more impulsive than healthy controls in all impulsivity dimensions we studied. Furthermore bipolar patients with a suicide attempt history have a greater cognitive impulsivity when compared to both bipolar patients without such a history as well when compared to healthy controls. No association was found between 5-HTTLPR genotypes and neuropsychological measures of impulsive behavior. Limitations: The sample studied can be considered small and a potentially confounding variable - medication status - was not controlled. Conclusion: A lifetime suicide attempt seems associated with cognitive impulsivity independently of the socio-demographic and clinical variables studied as well with 5-HTTLPR genotype. Further studies in larger samples are necessary. (C) 2011 Elsevier B.V. All rights reserved.
Cate of OECD: Clinical medicine
Year of Publication: 2011
Business Area: gamble
Detail Business: gamble
Country: Netherlands
Study Area:
Name of Journal: JOURNAL OF AFFECTIVE DISORDERS
Language: English
Country of Authors: [Malloy-Diniz, Leandro Fernandes; Paiva de Moraes, Paulo Henrique] Univ Fed Minas Gerais, Dept Psicol, Fac Filosofia & Ciencias Humanas, BR-30130100 Belo Horizonte, MG, Brazil; [Neves, Fernando Silva; Romano-Silva, Marco Aurelio; Correa, Humberto] Univ Fed Minas Gerais, Fac Med, Dept Saude Mental, BR-30130100 Belo Horizonte, MG, Brazil; [De Marco, Luiz Armando] Univ Fed Minas Gerais, Fac Med, Dept Cirurgia, BR-30130100 Belo Horizonte, MG, Brazil; [Krebs, Marie-Odile] Descartes Univ, St Anne Hosp, INSERM, Lab Pathophysiol Psychiat,U894, F-75674 Paris 14, France; [Malloy-Diniz, Leandro Fernandes; De Marco, Luiz Armando; Romano-Silva, Marco Aurelio; Correa, Humberto] Univ Fed Minas Gerais, Fac Med, INCT Med Mol, BR-30130100 Belo Horizonte, MG, Brazil
Press Adress: Malloy-Diniz, LF (reprint author), Univ Fed Minas Gerais, Dept Psicol, Fac Filosofia & Ciencias Humanas, Ave Antonio Carlos 6627,Sala 4010, BR-30130100 Belo Horizonte, MG, Brazil.
Email Address: malloy.diniz@gmail.com
Citaion: Romano-Silva, Marco/0000-0002-6558-4639; Malloy-Diniz, Leandro/0000-0002-6606-1354;
Funding: INCT-MM FAPEMIG [CBB-APQ-00075-09 / CNPq 573646/2008-2]; FAPEMIG [SHA-APQ-00741-09]; CNPq
Lists of Citation: Allen TJ, 1998, DRUG ALCOHOL DEPEN, V50, P137, DOI 10.1016/S0376-8716(98)00023-4; Ancin I, 2010, ACTA PSYCHIAT SCAND, V122, P235, DOI 10.1111/j.1600-0447.2009.01532.x; ASBERG M, 1976, ARCH GEN PSYCHIAT, V33, P1193; Bechara A, 2000, CEREB CORTEX, V10, P295, DOI 10.1093/cercor/10.3.295; Bechara A, 2005, CURR OPIN NEUROL, V18, P734, DOI 10.1097/01.wco.0000194141.56429.3c; Bondy B, 2006, MOL PSYCHIATR, V11, P336, DOI 10.1038/sj.mp.4001803; Campi-Azevedo AC, 2003, MOL PSYCHIATR, V8, P899, DOI 10.1038/sj.mp.4001381; Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968; Epstein JN, 2003, J ABNORM CHILD PSYCH, V31, P543, DOI 10.1023/A:1025405216339; Fleck DE, 2001, SCHIZOPHR RES, V52, P251, DOI 10.1016/S0920-9964(01)00170-0; Gorenstein C, 1998, REV PSIQUIATRIA CLIN, V25, P245; Goswami U, 2009, ACTA PSYCHIAT SCAND, V120, P456, DOI 10.1111/j.1600-0447.2009.01390.x; Gotlib IH, 2008, BIOL PSYCHIAT, V63, P847, DOI 10.1016/j.biopsych.2007.10.008; Hariri AR, 2002, SCIENCE, V297, P400, DOI 10.1126/science.1071829; Hollander E, 2001, LANCET, V358, P949, DOI 10.1016/S0140-6736(01)06114-1; Hu XZ, 2006, AM J HUM GENET, V78, P815, DOI 10.1086/503850; Jollant F, 2007, AM J MED GENET B, V144B, P615, DOI 10.1002/ajmg.b.30467; Malloy-Diniz L, 2007, J INT NEUROPSYCH SOC, V13, P693, DOI 10.1017/S1355617707070889; Malloy-Diniz LF, 2008, REV BRAS PSIQUIATR, V30, P144, DOI 10.1590/S1516-44462008005000009; Malloy-Diniz LF, 2009, J AFFECT DISORDERS, V112, P231, DOI 10.1016/j.jad.2008.03.019; Mann JJ, 2009, BIOL PSYCHIAT, V65, P556, DOI 10.1016/j.biopsych.2008.11.021; Moeller FG, 2001, AM J PSYCHIAT, V158, P1783, DOI 10.1176/appi.ajp.158.11.1783; Muller-Oerlinghausen B, 2002, LANCET, V359, P241, DOI 10.1016/S0140-6736(02)07450-0; Najt P, 2007, EUR NEUROPSYCHOPHARM, V17, P313, DOI 10.1016/j.euroneuro.2006.10.002; Neves FS, 2008, AM J MED GENET B, V147B, P114, DOI 10.1002/ajmg.b.30563; Neves F. S., 2009, J CLIN PSYCHIAT, V70, P1; Patton JH, 1995, J CLIN PSYCHOL, V51, P768, DOI 10.1002/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1; Pezawas L, 2005, NAT NEUROSCI, V8, P828, DOI 10.1038/nn1463; RAVEN JC, 2008, MATRIZES PROGR ESCAL; ROCHA FFD, 2008, BEHAV BRAIN RES, V195, P159, DOI DOI 10.1016/J.BBR.2008.05.015.PUBMED:18603313; Swann AC, 2008, J AFFECT DISORDERS, V106, P241, DOI 10.1016/j.jad.2007.07.011; Turecki G, 2005, J PSYCHIATR NEUROSCI, V30, P398; Vilela JAA, 2005, BRAZ J MED BIOL RES, V38, P1429, DOI 10.1590/S0100-879X2005000900019; Zelazo PD, 2004, ACTA PSYCHOL, V115, P167, DOI 10.1016/j.actpsy.2003.12.005
Number of Citaion: 34
Publication: ELSEVIER SCIENCE BV
City of Publication: AMSTERDAM
Address of Publication: PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
ISSN: 0165-0327
29-Character Source Abbreviation: J AFFECT DISORDERS
ISO Source Abbreviation: J. Affect. Disord.
Volume: 133
Version: 41641
Start of File: 221
End of File: 226
DOI: 10.1016/j.jad.2011.03.051
Number of Pages: 6
Web of Science Category: Clinical Neurology; Psychiatry
Subject Category: Neurosciences & Neurology; Psychiatry
Document Delivery Number: 820VR
Unique Article Identifier: WOS:000294934700027
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