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- Article] Effect of Xinfeng Capsule ((sic)) on the Cardiac Function in Patients with Rheumatoid Arthritis
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DocNo of ILP: 1766
Doc. Type: Article
Title: Effect of Xinfeng Capsule ((sic)) on the Cardiac Function in Patients with Rheumatoid Arthritis
Authors: Cao, YX; Liu, J; Zhu, Y
Full Name of Authors: Cao Yun-xiang; Liu Jian; Zhu Yan
Keywords by Author: rheumatoid arthritis; cardiac function; regulation T cell; inflammatory factor; Xinfeng Capsule
Keywords Plus: CARDIOVASCULAR-DISEASE; RISK
Abstract: Objective: To study the changes in cardiac function of rheumatoid arthritis (RA) patients and to observe the effect of Xinfeng Capsule ((sic), XFC) on them. Methods: Sixty-eight RA patients were randomly assigned to two groups by a lottery: 38 patients in the treatment group treated orally with XFC, 3 capsules, thrice a day, and 30 in the control group treated with Fengshi Gutong Capsule ((sic), FSGTC), 4 capsules, twice a day, 30 days as one course of treatment, and two courses were given for both groups. A normal control (NC) group including 20 healthy subjects was set up. The clinical efficacy was compared between the two treated groups. The changes in cardiac function, including early diastolic peak flow velocity (E), late diastolic peak flow velocity (A), left ventricular fraction shortening (FS), and E/A, as well as uric acid (UA), erythrocyte sedimentation rate (ESR), alpha -acid glycoprotein (alpha -AGP), and hypersensitive C-reaction protein (hs-CRP), were observed. The regulation T cell was determined with flow cytometry. Results: (1) The total effective rate in the treatment group and the control group was 92.1% (35/38) and 70.0% (21/30), respectively. Significant difference was shown between them (P<0.05). (2) Compared with those of the NC group, E peak, E/A ratio, and FS of RA patients were lower (P<0.01), while A peak was higher (P<0.01). Moreover, A peak of the treatment group after treatment was significantly lower (P<0.05) and E/A ratio was significantly higher (P<0.05) as compared with those of the control group. (3) The improvement in the treatment group in reducing UA and hs-CRP was superior to those of the control group (P<0.05). In addition, the improvement in alpha -AGP, CD4(+)CD25(+) Treg, and CD4(+)CD25(+)CD127(-) Treg of the treatment group was obvious as compared with the control group, although the difference was not statistically significant. Conclusions: The descendent of cardiac function exists in RA patients. XFC could improve cardiac function of RA patients, which is superior to FSGTC. Its mechanism may be related to its effect on raising CD4(+)CD25(+)Treg and CD4(+)CD25(+)CD127(-) Treg cells, decreasing UA, alpha -AGP, and hs-CRP levels, reducing immune inflammation, adjusting the overall balance of immune response, and thus improving the cardiac function of RA patients.
Cate of OECD: Clinical medicine
Year of Publication: 2011
Business Area: lottery
Detail Business: lottery
Country: USA
Study Area:
Name of Journal: CHINESE JOURNAL OF INTEGRATIVE MEDICINE
Language: English
Country of Authors: [Cao Yun-xiang; Liu Jian; Zhu Yan] Anhui Coll Tradit Chinese Med, Dept Rheumatol, Affiliated Hosp 1, Hefei 230031, Peoples R China
Press Adress: Liu, J (reprint author), Anhui Coll Tradit Chinese Med, Dept Rheumatol, Affiliated Hosp 1, Hefei 230031, Peoples R China.
Email Address: liujianahzy@yahoo.com.cn
Citaion:
Funding: National Key Discipline of Traditional Chinese Medicine Project for Bi Diseases [Administration of Traditional Chinese Medicine, China] [30]; Science and Technology Department of Anhui Province, China [07010300204]; Health Department of Anhui Province, China [2009ZY05]
Lists of Citation: CHEN RL, 2008, CHIN J CLIN HEALTHCA, V6, P606; CHENG X, 2006, MOL CARDIOL CHINA, V6, P17; LIU J, 2002, CHINA J TRADIT CHIN, V17, P159; LIU J, 2007, CHIN J TRADIT MED SC, V14, P389; LIU J, 2001, CHIN J BASIC MED TRA, V7, P13; Liu Jian, 2008, Journal of Chinese Integrative Medicine, V6, P606, DOI 10.3736/jcim20080612; MA J, 2006, CHIN J CLIN REHABIL, V10, P55; Panoulas VF, 2007, RHEUMATOLOGY, V46, P1466, DOI 10.1093/rheumatology/kem159; Peters MJL, 2009, ARTHRIT RHEUM-ARTHR, V61, P1571, DOI 10.1002/art.24836; Rheumatology Branch of Chinese Medical Association, 2003, CHIN RHEUMATOL, V7, P250; Solomon DH, 2006, ARTHRITIS RHEUM, V54, P1378, DOI 10.1002/art.21887; van Halm VP, 2009, ANN RHEUM DIS, V68, P1395, DOI 10.1136/ard.2008.094151; Wang B, 2005, CHIN J INTEGR MED CA, V3, P162; [文彩虹 WEN Cai-hong], 2009, [?瘤, Tumor], V29, P1003; XU CJ, 2008, CHIN J CLIN PHARM TH, V13, P499; [?志? ZHAO Zhiguo], 2008, [北京中??大???, Journal of Beijing University of Traditional Chinese Medicine], V31, P106; ZHENG HZ, 1998, MODERN STUDY TRADITI, V5, P4492; Zheng XY, 2002, GUIDING PRINCIPLE CL, P115; ZHOU YC, 2006, ULTRASONIC MED, P682
Number of Citaion: 19
Publication: SPRINGER
City of Publication: NEW YORK
Address of Publication: 233 SPRING ST, NEW YORK, NY 10013 USA
ISSN: 1672-0415
29-Character Source Abbreviation: CHIN J INTEGR MED
ISO Source Abbreviation: Chin. J. Integr. Med.
Volume: 17
Version: 10
Start of File: 738
End of File: 743
DOI: 10.1007/s11655-011-0873-1
Number of Pages: 6
Web of Science Category: Integrative & Complementary Medicine
Subject Category: Integrative & Complementary Medicine
Document Delivery Number: 829BC
Unique Article Identifier: WOS:000295548600004
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