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- Article] Development and Validation of a Utility Weighting Function for the Patient-Oriented Prostate Utility Scale (PORPUS)
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DocNo of ILP: 1626
Doc. Type: Article
Title: Development and Validation of a Utility Weighting Function for the Patient-Oriented Prostate Utility Scale (PORPUS)
Authors: Tomlinson, G; Bremner, KE; Ritvo, P; Naglie, G; Krahn, MD
Full Name of Authors: Tomlinson, George; Bremner, Karen E.; Ritvo, Paul; Naglie, Gary; Krahn, Murray D.
Keywords by Author: valuation functions; utility measurement; preference weights; prostate cancer
Keywords Plus: QUALITY-OF-LIFE; STATE CLASSIFICATION-SYSTEM; DECISION-ANALYSIS; STANDARD GAMBLE; CANCER PATIENTS; HEALTH; INDEX; PREFERENCES; VALIDITY; RELIABILITY
Abstract: Background. Previously, we developed a prostate cancer (PC)-specific health state classification system, the Patient Oriented Prostate Utility Scale (PORPUS). In this study, we developed a scoring system to allow indirect calculation of utilities from the PORPUS. Methods. We interviewed 234 PC outpatients, including those with newly diagnosed and metastatic disease, to obtain rating scale (RS) values on 4 to 6 levels of each of the 10 attributes of the PORPUS, and on 10 corner states (worst level on 1 attribute, best on 9). Patients also completed standard gamble (SG) and RS tasks on 4 multiattribute states (impotence and pain corner states, mild and severe PC symptoms). We used the RS and SG scores for multiattribute states to determine a risk aversion function for mapping values to utilities. We then tested 15 different strategies to estimate the multiattribute utility function (MAUF), using the single attribute disutilities for each level of the 10 PORPUS attributes, and the disutilities for the corner states. The root mean squared error (RMSE) of prediction of the SG on the 4 multiattribute states was used to identify the optimal strategy and scoring system. Results. The optimal strategy gave an RMSE of 0.06. Comparison of mean MAUF-predicted utilities to directly elicited SG utilities for the 2 multiattribute states from patients in 2 previously published studies (n = 248 and n = 141) supported the validity of the MAUF. Conclusions. The scoring system together with the PORPUS comprise an indirect utility instrument, the PORPUS-U, which can be used in clinical and research settings.
Cate of OECD: Health sciences
Year of Publication: 2012
Business Area: other
Detail Business: medicine & science
Country: USA
Study Area:
Name of Journal: MEDICAL DECISION MAKING
Language: English
Country of Authors: [Tomlinson, George; Naglie, Gary; Krahn, Murray D.] Univ Toronto, Dept Hlth Policy Management & Evaluat, Toronto, ON, Canada; [Tomlinson, George; Naglie, Gary; Krahn, Murray D.] Univ Toronto, Dept Med, Toronto, ON, Canada; [Krahn, Murray D.] Univ Toronto, Fac Pharm, Toronto, ON, Canada; [Tomlinson, George; Bremner, Karen E.; Krahn, Murray D.] Univ Hlth Network, Toronto Gen Res Inst, Toronto, ON, Canada; [Ritvo, Paul] Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada; [Ritvo, Paul] Canc Care Ontario, Toronto, ON, Canada; [Naglie, Gary] Baycrest Ctr Geriatr Care, Toronto, ON, Canada; [Tomlinson, George; Bremner, Karen E.; Krahn, Murray D.] Toronto Hlth Econ & Technol Assessment Collaborat, Toronto, ON, Canada; [Tomlinson, George] Univ Toronto, Dept Publ Hlth Sci, Toronto, ON, Canada
Press Adress: Tomlinson, G (reprint author), Toronto Gen Hosp, EN13-238,200 Elizabeth St, Toronto, ON M5G 2C4, Canada.
Email Address: george.tomlinson@utoronto.ca
Citaion:
Funding: National Cancer Institute of Canada (NCIC) [011393]; Mary Trimmer Chair in Geriatric Medicine Research; F. Norman Hughes Chair in Pharmacoeconomics, Faculty of Pharmacy, University of Toronto
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Number of Citaion: 54
Publication: SAGE PUBLICATIONS INC
City of Publication: THOUSAND OAKS
Address of Publication: 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
ISSN: 0272-989X
29-Character Source Abbreviation: MED DECIS MAKING
ISO Source Abbreviation: Med. Decis. Mak.
Volume: 32
Version: 1
Start of File: 11
End of File: 30
DOI: 10.1177/0272989X11407203
Number of Pages: 20
Web of Science Category: Health Care Sciences & Services; Medical Informatics
Subject Category: Health Care Sciences & Services; Medical Informatics
Document Delivery Number: 884JN
Unique Article Identifier: WOS:000299701100007
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