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- Article] Variants in the Dopamine-4-Receptor Gene Promoter Are Not Associated with Sensation Seeking in Skiers
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DocNo of ILP: 66
Doc. Type: Article
Title: Variants in the Dopamine-4-Receptor Gene Promoter Are Not Associated with Sensation Seeking in Skiers
Authors: Thomson, CJ; Rajala, AK; Carlson, SR; Rupert, JL
Full Name of Authors: Thomson, Cynthia J.; Rajala, Amelia K.; Carlson, Scott R.; Rupert, Jim L.
Keywords by Author:
Keywords Plus: DOPAMINE-D4 RECEPTOR GENE; TANDEM DUPLICATION POLYMORPHISM; DEFICIT HYPERACTIVITY DISORDER; PERSONALITY-TRAITS; NOVELTY SEEKING; DRD4 GENE; REGION; ADHD; SCHIZOPHRENIA; METAANALYSIS
Abstract: Sensation seeking is a personality trait that has been associated with disinhibited behaviours including substance use and gambling, but also with high-risk sport practices including skydiving, paragliding, and downhill skiing. Twin studies have shown that sensation seeking is moderately heritable, and candidate genes encoding components involved in dopaminergic transmission have been investigated as contributing to this type of behaviour. To determine whether variants in the regulatory regions of the dopamine-4-receptor gene (DRD4) influenced sport-specific sensation seeking, we analyzed five polymorphisms (-1106T/C, -906T/C, -809G/A, -291C/T, 120-bp duplication) in the promoter region of the gene in a cohort of skiers and snowboarders (n = 599) that represented a broad range of sensation seeking behaviours. We grouped subjects by genotype at each of the five loci and compared impulsive sensation seeking and domain-specific (skiing) sensation seeking between groups. There were no significant associations between genotype(s) and general or domain-specific sensation seeking in the skiers and snowboarders, suggesting that while DRD4 has previously been implicated in sensation seeking, the promoter variants investigated in this study do not contribute to sensation seeking in this athlete population.
Cate of OECD: Other natural sciences
Year of Publication: 2014
Business Area: gamble
Detail Business: gamble
Country: USA
Study Area:
Name of Journal: PLOS ONE
Language: English
Country of Authors: [Thomson, Cynthia J.; Rupert, Jim L.] Univ British Columbia, Sch Kinesiol, Vancouver, BC V5Z 1M9, Canada; [Rajala, Amelia K.] Univ British Columbia, Dept Sci, Vancouver, BC V5Z 1M9, Canada; [Carlson, Scott R.] Univ Minnesota, Dept Psychol, Duluth, MN 55812 USA
Press Adress: Thomson, CJ (reprint author), Univ British Columbia, Sch Kinesiol, Vancouver, BC V5Z 1M9, Canada.
Email Address: cynthia.thomson@questu.ca
Citaion:
Funding: Canadian Institute for Health Research; British Columbia Mental Health and Addictions Research; Deutscher Akademischer Austausch Dienst (DAAD; German Academic Exchange Service)
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Number of Citaion: 41
Publication: PUBLIC LIBRARY SCIENCE
City of Publication: SAN FRANCISCO
Address of Publication: 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
ISSN: 1932-6203
29-Character Source Abbreviation: PLOS ONE
ISO Source Abbreviation: PLoS One
Volume: 9
Version: 4
Start of File:
End of File:
DOI: 10.1371/journal.pone.0093521
Number of Pages: 5
Web of Science Category: Multidisciplinary Sciences
Subject Category: Science & Technology - Other Topics
Document Delivery Number: AE6KM
Unique Article Identifier: WOS:000334101100096
[이 게시물은 HyeJung Mo…님에 의해 2015-05-20 20:12:52 GAMBLING에서 이동 됨]
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